Nitric oxide releasing steroids

ABSTRACT

The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof wherein R is a corticosteroid residue selected from: The compounds are useful in the treatment of respiratory diseases.

The present invention relates to use of nitric oxide releasing steroidal compounds having an improved pharmacological activity and low side effects in the treatment of respiratory diseases, and to a process for their preparation. The present invention also relates to nitric oxide releasing steroidal compounds and to pharmaceutical formulations containing them.

Respiratory diseases comprise asthma, COPD (chronic obstructive pulmonary diseases), ARDS (Acute Respiratory Distress Syndrome), allergic rhinitis, respiratory tract diseases associated with inflammation.

At present, the most drugs used in the treatment of respiratory diseases are steroids. However the currently available steroids have unsatisfactory site selectivity, for example all inhaled steroids are absorbed systemically from the lungs, and thus cause serious adverse effects by long-term administration.

Therefore, there is a demand for development of a new class of compounds for use in the treatment of respiratory diseases which exerts a powerful effect and low systemic effect.

BACKGROUND OF THE INVENTION

In the prior art nitrooxy derivatives of steroids, which are usable also as cardiovascular agents for the coronary insufficiency or angina pectoris therapy, are described.

For example, German patent DE 2,222,491 describes the preparation of pregnane derivatives having in position 21 the —CH₂—O—NO₂ group. In said patent it is stated that said derivatives have a cardiotropic activity. This activity represents a drawback for said compounds, since they modify the cardiac frequency.

U.S. Pat. No. 3,494,941 describes steroid derivatives from 3-hydroxyextrane or from extr-4 en-3 one, used as vasodilators in the treatment of cardiac affections such as coronary insufficiency and angina pectoris. In the structure of said compounds a ONO₂ group is at the free end of the alkylene chain which is linked by an ether bond to the steroid in position 17. According to said patent it is possible to have nitrate groups also in the positions 3 and 16 of the steroidal structure. The same drawbacks mentioned above as regards the effects on the cardiac frequency can be repeated for the compounds of this patent.

U.S. Pat. No. 3,183,252 describes derivatives of 16-nitrate-alkylpregnanes wherein the alkyl group is linked to the pregnane structure by a carbon-carbon bond. The compounds according to said patent can be used as vasodilators. The same drawbacks reported for the above prior art can be repeated.

WO 98/15568 and WO 03/064443 in the name of the Applicant describe nitrate esters of steroidal compounds, wherein between the steroidal structure and the nitrooxy group a bivalent linking group is inserted. Said compounds show a good efficacy and/or good tolerability with respect to the corresponding precursors.

Patent application WO 00/61604 in the name of the Applicant describes nitrooxy derivatives of steroidal compounds with various linking groups having at one end a nitrooxy group, and covalently linked with the other end to a steroidal compound. In said application the uses concern the compounds usable in the treatment of patients in oxidative stress. Said compounds contain in the molecule also a bivalent linking group which must be capable to prevent the free radicals production and is selected on the basis of the tests reported therein.

The Applicant has surprisingly and unexpectedly found a class of nitric oxide releasing compounds with a better efficacy, bioavailability and/or a prolonged release of NO in comparison with the compounds known in prior art. In general the compounds of the present invention have a better drugability in comparison to the corresponding compounds of the prior art.

An object of the present invention is to provide nitric oxide releasing compounds of general formula (I)

R-(Z)_(a)-R_(x)  (I)

and pharmaceutically acceptable salts or stereoisomers thereof for use in the treatment of respiratory diseases, wherein in formula (I) R is a corticosteroid residue selected from:

a is 0 or 1, Z is a group capable of binding R_(X) and is selected from —C(O)—, or —CH(R′)—O— wherein R′ is selected from H or a straight or branched C₁-C₄ alkyl, preferably R′ is H or —CH₃; R_(x) is a radical selected from the following meanings:

A)

(a1) —HN—CH(R¹)—C(O)-(T-Y—ONO₂)

(a2) —C(O)—CH(R¹)—NH-(T′-Y—ONO₂)

(a3) —HN—CH(R^(1a)-T″-Y′—ONO₂)—COOR^(3a)

(a4) —C(O)—CH(R^(1a)-T″-Y′—ONO₂)—NHR^(4a)

(a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂)

(a6) —R^(1b)—CH(COOR^(1a)) NH-(T′-Y′—ONO₂)

(a7) —HN—CH(R^(1a)-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂)

(a8) —C(O)—CH(R^(1a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂)

(a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂)

(a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂)

wherein:

R¹ is selected from:

-   -   A1) H, —CH₃, isopropyl, isobutyl, sec-butyl, tert-butyl,         methylthio-(CH₂)₂—, phenyl, benzyl, C₆H, —CH₂—CH₂—,         2-monosubstituted benzyl, or 3-monosubstituted benzyl or         4-monosubstituted benzyl wherein the substituent of the benzyl         is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN, C₆H₅CO—;     -    2,4-dichlorobenzyl, 3,4-dichlorobenzyl, 3,4-difluorobenzyl,         2-pyrrolidyl, 3-tryptophanyl-CH₂—, 3-benzothienyl-CH₂—,         4-imidazolyl-CH₂—, 9-anthranyl-CH₂—, cyclohexyl,     -    cyclohexyl-CH₂—, cyclohexyl-(CH₂)₂—, cyclopentyl-CH₂—,         (C₆H₅)₂CH—, 4-B(OH)₂-benzyl, 4-quinolyl-CH₂—, 3-quinolyl-CH₂—,         2-quinolyl-CH₂—,     -    2-quinoxalyl-CH₂—, 2-furyl-CH₂—, 1-naphtyl-CH₂—,         2-naphtyl-CH₂—, 2-pyridyl-CH₂—, 3-pyridyl-CH₂—, 4-pyridyl-CH₂—,         2-thienyl-CH₂—, 3-thienyl-CH₂—, C₆H₄—CH═CH—CH₂—, CH₂═CH—CH₂—,         CH≡CH—CH₂—, NH₂—CO—CH₂—, NH₂—CO—(CH₂)₂—, NH₂(═NH)NH—(CH₂)₃—,         P(═O)(OCH₃)₂, I—CH₂—, preferably R¹ is H, —CH₃, isopropyl,         benzyl;     -   A2) —CH₂—SH, —CH₂—OH, —CH(CH₃)—OH, —CH₂[(C₆H₄)-(4-OH)],         —CH₂—[(C₆H₂)-(3,5-diiodo)-(4-OH)]     -    —CH₂—[(C₆H₃)-(3-nitro)-(4-OH)], preferably R¹ is —CH₂—OH or         —CH₂[(C₆H₄)-(4-OH)];     -   A3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein         R″ is H, —C(O)CH₃ or

-   -    wherein R^(5a) is H or a linear or branched C₁-C₁₀ alkyl chain,         preferably R^(5a) is H or a linear (C₁-C₅) alkyl, preferably R¹         is —(CH₂)₄—NHR″, wherein R″ is as above defined,     -   A4) —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′         is —OR^(5a) or

-   -    wherein R^(5a) is as above defined, preferably R¹ is         —CH₂—C(O)R″′, wherein R″′ is as above defined,

R^(1a) is selected from:

-   -   A5) —CH₂—S—, —CH₂—O—, —CH(CH₃)—O—, —CH₂[(C₆H₄)-(4-O)—],         —CH₂-[(3,5-diiodo)-(C₆H₂)-(4-O)—],         —CH₂-[(3-nitro)-(C₆H₃)-(4-O)—], preferably R^(1a) is —CH₂—O—;     -   A6) —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, preferably         R^(1a) is —(CH₂)₄—NH— or —CH₂—NH—,     -   A7) —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, preferably R^(1a)         is —CH₂—C(O)—;

R^(3a) is selected from H, —R^(5a) or

-   -   wherein R^(5a) is as above defined,

R^(4a) is selected from H or —C(O)CH₃ or

wherein R^(5a) is as above defined,

R^(1b) is selected from

-   -   A8) —S—CH₂—, —O—CH(CH₃)—, —O—CH₂—, [-(4-O)—(C₆H₄)]—CH₂—,         [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂—,         [-(4-O)-(3-nitro)-(C₆H₃)]—CH₂—, preferably R^(1b) is —O—CH₂— or         [-(4-O)—(C₆H₄)]—CH₂—;     -   A9) —HN—CH₂—, —HN—(CH₂)₂—, —HN—(CH₂)₃—, —HN—(CH₂)₄—, preferably         R^(1b) is —HN—(CH₂)₄— or —HN—CH₂—;     -   A10) —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, preferably R^(1b)         is —C(O)—CH₂—;         T is selected from —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— or         —O—CH(R′)—O—C(O)O— wherein R′ is as above defined;         T′ is —C(O)—, —C(O)—X″— wherein X″ is —O— or —S—, or T′ is         —C(O)—NR′— wherein R′ is as above defined;         T″ is independently selected from —C(O)—, —C(O)—X″—, —C(O)—NR′—,         —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—, —O—CH(R′)—O—C(O)O—, wherein         X″ and R′ are as above defined, with the proviso that T″ is         —C(O)—, —C(O)—X″— or —C(O)—NR′— when T″ is linked to —NH—, —O—,         or —S—, or         T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—, —O—CH(R′)—O—C(O)O—         when T″ is linked to —C(O)—,         Y and Y′ are as below defined;         or R_(x) is selected from:

B)

(b1) —HN—CH(R²)—CH₂—C(O)-(T-Y—ONO₂)

(b2) —C(O)—CH₂—CH(R²)—NH-(T′-Y—ONO₂)

(b3) —HN—CH(R^(2a)-T″-Y′—ONO₂)—CH₂COOR^(3a)

(b4) —C(O)—CH₂—CH(R^(2a)-T″-Y′—ONO₂)—NHR^(4a)

(b5) —R^(2b)—CH(NHR^(4a))—CH₂C(O)-(T-Y—ONO₂)

(b6) —R²—CH(CH₂COOR^(3a))NH-(T′-Y—ONO₂)

(b7) —HN—CH(R^(2a)-T″-Y′—ONO₂)—CH₂—C(O)-(T-Y—ONO₂)

(b8) —C(O)—CH₂—CH(R^(2a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂)

(b9) —R²—CH(NH-T′-Y′—ONO₂)—CH₂C(O)-(T-Y—ONO₂)

(b10) —R²—CH(CH₂C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂)

wherein

R² is selected from:

B1) H, —CH₃, CF₃, isopropyl, isobutyl, sec-butyl, methylthio-(CH₂)₂—, phenyl, benzyl, 3-tryptophanyl-CH₂—, NH₂—C(O)—CH₂—, NH₂—C(O)—(CH₂)₂—, NH₂(═NH)NH—(CH₂)₃—, tBuO—CH(CH₃)—, benzyl-O—CH₂—, 4-terbutoxy-benzyl, 4-phenylbenzyl, preferably R² is H, —CH₃, isopropyl, benzyl,

B2) —CH₂—SH, —CH₂—OH, —CH(CH₃)—OH, —CH₂—[(C₆H₄)-(4-OH)], —CH₂—[(C₆H₂)-(3,5-diiodo)-(4-OH)]

—CH₂—[(C₆H₃)-(3-nitro)-(4-OH)];

B3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is as above defined, preferably R² is —(CH₂)₄—NHR″;

B4) —CH₂—C(O)—R″′, —(CH₂)₂—C(O)—R″′, —(CH₂)₄—C(O)—R″′ wherein R″′ is as above defined, preferably R² is —CH₂—C(O)—R″′;

R^(2a) is selected from:

B5) CH₂—S—, CH₂—O—, —CH(CH₃)—O— or CH₂[(C₆H₄)-(4-O)—], —CH₂-[(3,5-diiodo)-(C₆H₂)-(4-O)—], —CH₂-[(3-nitro)-(C₆H₃)-(4-O)—], preferably R^(2a) is —CH₂—O—;

B6) —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, preferably R^(2a) is —(CH₂)₄—NH— or —CH₂—NH—;

B7) —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, preferably R^(2a) is —CH₂—C(O)—;

R^(2b) is selected from

B8) —S—CH₂—, —O—CH(CH₃)—, —O—CH₂—, [-(4-O)—(C₆H₄)]—CH₂—, [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂—, [-(4-O)-(3-nitro)-(C₆H₃)]—CH₂—, preferably R^(2b) is —O—CH₂— or [-(4-O)—(CH₄)]—CH₂—;

B9) —HN—CH₂—, —HN—(CH₂)₂—, —HN—(CH₂)₃—, —HN—(CH₂)₄—, preferably R^(2b) is —HN—(CH₂)₄— or —HN—CH₂—;

B10) —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, preferably R^(2b) is —C(O)—CH₂—;

R^(3a) and R^(4a) are as above defined; T, T′ and T″ are as above defined and Y and Y′ are as below defined; or R_(x) is selected from:

C)

(c1) —HN—(CH₂)_(b)—C(O)-(T-Y—ONO₂); (c2) —C(O)—(CH₂)_(b)—NH-(T′-Y—ONO₂) wherein b is an integer from 3 to 6, T and T′ are as above defined and Y and Y′ are as below defined;

D)

(d1) —HN—CH(R¹²)—CH₂—O-(T″′-Y—ONO₂) (d2) —O—CH₂—CH(R¹²)—NH-(T′-Y—ONO₂) (d3) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂OH (d4) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NHR^(4a) (d5) —R^(12a)—CH(NHR^(4a))—CH₂—O-(T″′-Y—ONO₂) (d6) —R^(12b)—CH(CH₂OH)—NH-(T′-Y—ONO₂) (d7) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) (d8) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) (d9) —R^(12b)—CH(NH-T′-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) (d10) —R^(12b)—CH(CH₂—O-T″′-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein T″′ is independently selected from —C(O)—, —C(O)X″— wherein X″ is —O— or —S—, or —C(O)—NR′— wherein R′ is as above defined; T′ and T″ are as above defined, Y and Y′ are as below defined; R¹² is selected from:

D1) H, —CH₃, isopropyl, isobutyl, sec-butyl, methylthio-(CH₂)₂—, benzyl, 3-triptophanyl-CH₂—, 4-imidazolyl-CH₂—, NH₂—CO—CH₂—, NH₂—CO—(CH₂)₂—, NH₂(═NH)NH—(CH₂)₃—, preferably R¹² is H;

D2) —CH₂—OH, —CH(CH₃)—OH, —CH₂[(C₆H₄)-(4-OH)], —CH₂—[(C₆H₃)— (3,5-diiodo)-(4-OH)],

—CH₂—[(C₆H₃)-(3-nitro)-(4-OH)] preferably R′ is —CH₂—OH or —CH₂[(C₆H₄)-(4-OH)]

D3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is as above defined, preferably R¹² is —(CH₂)₄—NHR″;

D4) —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is as above defined, preferably R¹² is —CH₂—C(O)R″′;

R^(12a) is selected from

D5) —CH₂—O—, —CH(CH₃)—O— or —CH₂[(C₆H₂)-(4-O)—], —CH₂-[3,5-diiodo-(C₆H₂)-(4-O)—], —CH₂-[3-nitro-(C₆H₃)-4-O—], preferably R^(12a) is CH₂—O— or —CH₂—[(C₆H₄)-(4-O)—],

D6) —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, preferably R^(12a) is —(CH₂)₄—NH— or —CH₂—NH—,

D7) —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, preferably R^(12a) is —CH₂—C(O)—,

R^(12b) is selected from

D8) —O—CH₂—, —O—CH(CH₃)—, [-(4-O)—(C₆H₄)]—CH₂—, [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂, [-(4-O)-(3-nitro)-(C₆H₃)]—CH₂—, preferably R¹² is —O—CH₂— or [-(4-O)—(C₆H₄)]—CH₂—;

D9) —HN—CH₂—, —HN— (CH₂)₂—, —HN— (CH₂)—-HN— (CH₂)₄—, preferably R^(12b) is —HN— (CH₂)₄— or —HN—CH₂—;

D10) —C(O)—CH₂—, —C(O)— (CH₂)₂—, —C(O)—(CH₂)₄—, preferably R^(12b) is —C(O)—CH₂—;

R^(4a) is as above defined; or R_(x) is selected from:

E)

wherein c is equal to 0 or 1, d is an integer from 0 to 3 with the proviso that c is 0 or 1 when d is 0 and c is 0 when d is 1, 2 or 3, T and T′ are as above defined and Y is as below defined;

F)

(XI)

wherein e and f are equal to 0 or 1, with the proviso that f is 0 when e is 0 and f is 0 or 1 when e is 1, T and t′ are as above defined and y is as below reported;

G)

wherein R³ is H, CH₃, propyl, (C₆H₅)₂CH—, 1-naphtyl-CH₂—, benzyl, allyl, 2-bromobenzyl, 2-chlorobenzyl, 3-chlorobenzyl, 4-fluorobenzyl, 4-bromobenzyl, 4-methylbenzyl, preferably R³ is H, T and T′ are as above defined and Y is as below defined;

H)

wherein R⁴ is H, benzyl, 4-bromobenzyl, 2-bromobenzyl, T and T′ are as above defined and Y is as below defined;

I)

wherein R⁵ is H, R⁶ is H, or R⁵ and R⁶ when taken together are a double bond, T and T′ are as above defined and Y is as below reported;

L)

wherein T and T′ are as above defined and Y is as below reported;

M)

wherein T and T′ are as above defined and Y is as below reported;

N)

wherein c is as above defined, d is equal to 0 or 1, T and T′ are as above defined and Y is as below reported;

O)

wherein R⁷ is H, R⁸ is H, or R⁷ and R⁸ when taken together are a double bond, c is as above defined, T and T′ are as above defined and Y is as below reported;

P)

wherein T and T′ are as above defined and Y is as below reported;

Q)

wherein T and T′ are as above defined and Y is as below reported;

R)

wherein T and T′ are as above defined and Y is as below reported;

S)

wherein T and T′ are as above defined and Y is as below reported;

T)

wherein T and T′ are as above defined and Y is as below reported;

U)

wherein R⁹ and R¹⁰ are H, CH₃, R¹¹ is CH₃ or 4-piperidinyl with the proviso that R⁹ and R¹⁰ are H when R¹¹ is 4-piperidinyl and R⁹ and R¹⁰ are CH₃ when R¹¹ is CH₃, T and T′ are as above defined and Y is as below reported;

V)

wherein T and T′ are as above defined and Y is as below reported; with the proviso that in the formula (I): a is 0 or a is 1 and Z is —CH(R′)—O— wherein R′ is as above defined, when R_(x) is:

(a2), (a4) or (a8);

(a5), (a6), (a9) or (a10) and R^(1b) is selected from the group A10);

(b2), (b4) or (b8)

(b5), (b6), (b9) or (b10) and R^(2b) is selected from the group B10);

(c2);

(d5), (d6), (d9) or (d10) and R^(12b) is selected from the group D10);

(e2), (f1), (g2), (h1), (i1), (l2), (m2), (n2), (o2), (p2), (q2), (r2), (s2), (t1) or (u2);

a is 1 and Z is —C(O)—, when R_(x) is:

(a1), (a3) or (a7);

(a5), (a6), (a9) or (a10) and R^(1b) is selected from the groups A8) and A9);

(b1), (b3) or (b7);

(b5), (b6), (b9) or (b10) and R^(2b) is selected from the groups B8) or B9);

(c1);

(d1), (d2), (d3), (d4), (d7) or (d8);

(d5), (d6), (d9) or (d10) and R^(2b) is selected from the groups D8) or D9);

(e1), (f2), (g1), (h2), (i2), (l1), (m1), (n1), (o1), (p1), (q1), (r1), (s1), (t2) or (u1).

Y and Y′ are bivalent radicals each independently selected from the following meanings: a)

straight or branched C₁-C₂₀ alkylene, preferably a straight or branched C₁-C₁₀ alkylene,

straight or branched C₁-C₂₀ alkylene substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, —ONO₂ or T₂, wherein T₂ is —OC(O)(C₁-C₁₀ alkyl)-ONO₂ or —O(C₁-C₁₀ alkyl)-ONO₂, preferably Y or Y′ is a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group;

cycloalkylene with 5 to 7 carbon atoms into cycloalkylene ring, the ring being optionally substituted with one or more straight or branched C₁-C₁₀ alkyl chains, preferably the ring being optionally substituted with CH₃;

b)

wherein n⁰ is an integer from 0 to 20, preferably n^(C) is 0 or 1; n¹ is 0 or 1, preferably n¹ is 1;

U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a ONO₂ group, preferably U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group;

c)

wherein n⁰ is an integer from 0 to 20, preferably n^(C) is 0 or 1; n¹ is 0 or 1, preferably n¹ is 1;

U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group, preferably U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group;

d)

wherein: n² is an integer from 0 to 2, R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—; n¹ and U are as above defined; e)

n² is an integer from 0 to 2, preferably n² is 1; R¹³ is H or CH₃, preferably R¹³ is CH₃; Y¹ is —CH₂—CH₂— or —CH═CH—(CH₂)₂—, wherein n is 0 or 1, preferably Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n^(2′) is 0; T₁=—O—C(O)— or —C(O)O—, preferably T₁ is —C(O)O—; n¹ is 0 or 1, preferably n¹ is 1; U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a ONO₂ group, preferably U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; more preferably n² is 1, R¹³ is CH₃, Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n^(2′) is 0, T₁ is C(O)O— and U is a linear C₁-C₁₀ alkylene; e′)

wherein: n² is an integer from 0 to 2, preferably n2 is 1; R¹³ is H or CH₃, preferably R¹³ is CH₃; Y¹ is —CH₂—CH₂— or —(CH₂)_(n) ^(2′)—CH═CH—, wherein n is 0 or 1, preferably Y¹ is —(CH₂)_(n) ^(2′)—CH═CH— and n^(2′) is 0;

T₁=—O—C(O)—;

n¹ is 0 or 1, preferably n¹ is 1; U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group, preferably U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; more preferably n² is 1, R¹³ is CH₃, Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n^(2′) is 0, T₁ is —OC(O)— and U is a linear C₁-C₁₀ alkylene; f)

wherein T₂ is —O— or —S—, —NH—, preferably T₂ is —O—, n³ is an integer from 1 to 6, preferably n³ is 1; when Y and Y′ are selected from b), c), d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T′-Y—ONO₂), -(T″-Y′—ONO₂), -(T′-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group; g)

wherein: n⁴ is an integer from 0 to 10, preferably n⁴ is 0 or 1; n⁵ is an integer from 1 to 10, preferably n⁵ is 1;

R¹⁴, R¹⁵, R¹⁶, R¹⁷ are the same or different, and are H or straight or branched C₁-C₄ alkyl, preferably R¹⁴, R¹⁵, R¹⁶ and R¹⁷ are H;

wherein the —ONO₂ group is linked to

wherein n⁵ is as defined above;

Y² is an heterocyclic saturated, unsaturated or aromatic 5 or 6 members ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulphur,

and is selected from the group consisting of:

The term “C₁-C₁₀ alkyl” as used herein refers to branched or straight alkyl groups including methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, t-butyl, pentyl, hexyl, octyl and the like.

The term “cycloalkylene” as used herein refers to ring having from 5 to 7 carbon atoms including, but not limited to, cyclopentylene, cyclohexylene optionally substituted with side chains such as straight or branched (C₁-C₁₀)-alkyl, preferably CH₃.

The term “heterocyclic” as used herein refers to saturated, unsaturated or aromatic 5 or 6 members ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulphur, such as for example pyridine, pyrazine, pyrimidine, pyrrolidine, morpholine, imidazole and the like.

Respiratory diseases comprises asthma, COPD (chronic obstructive pulmonary diseases), ARDS (Acute Respiratory Distress Syndrome), allergic rhinitis, respiratory tract diseases associated with inflammation.

An embodiment of the invention relates to nitric oxide releasing compounds of general formula (I)

R-(Z)_(a)-R_(x)  (I)

and pharmaceutically acceptable salts or stereoisomers thereof for use in the treatment of respiratory diseases wherein in formula (I) the corticosteroid residue R is selected from:

a is 0 and R_(X) is selected from: (a2) —C(O)—CH(R¹)—NH-(T′-Y—ONO₂) wherein R¹ of the group A1) is selected from H, isobutyl, benzyl, C₆H₅—CH₂—CH₂—, 2-monosubstituted benzyl, or 3-monosubstituted benzyl or 4-monosubstituted benzyl wherein the substituent of the benzyl is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN, C₆H₅CO—; R¹ of the group A2) is selected from —CH₂—OH, —CH(CH₃)OH— or —CH₂[(C₆H₄)-(4-OH)], or R¹ of the group A3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, or —C(O)CH₃; R¹ of the group A4) is selected from —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl; T′ is —C(O)—, —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ is —C(O)—; Y is as below defined;

or R_(X) is

(a4) —C(O)—CH(R^(1a)-T″-Y′—ONO₂)—NHR^(4a) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)O— or —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is selected from —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—,

R^(4a) is H or —C(O)CH₃,

T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, when R^(1a) is selected from the group A5) or A6), preferably T″ is —C(O)—; T″ is —O—, —S—, —NR′— or —O—CH(R′)—O—C(O)— wherein R′ is H or —CH₃, when R^(1a) is selected from the group A7), Y′ is as below defined; or R_(X) is selected from: (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) (a6) —R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂) (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) or (a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1b) of the group A10) is selected from —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, R^(3a) is H or a (C₁-C₅) alkyl,

R^(4a) is H or —C(O)CH₃,

T is —O—, —S—, —NR′— or —O—CH(R′)—O—C(O)— wherein R′ is H or —CH₃, preferably T is —O—, T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ is —C(O)—, Y and Y′ are as below defined;

or R_(X) is

(a8) —C(O)—CH(R^(1a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)—O— or —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is selected from —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, when R^(1a) is selected from the group A5) or A6), preferably T″ is —C(O)—, T″ is —O—, —S—, —NR′— or —O—CH(R′)—O—C(O)— wherein R′ is H or —CH₃, when R^(1a) is selected from the group A7);

T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ is —C(O)—,

Y and Y′ are as below defined,

or R_(X) is

(b2) —C(O)—CH₂—CH(R²)—NH-(T′-Y—ONO₂) wherein R² of the group B1) is selected from H, CH₃, isobutyl, isopropyl, benzyl; T′ is —C(O)—, —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ is —C(O)—; Y and Y′ are each independently selected from a)

-   -   a straight or branched C₁-C₁₀ alkylene,     -   a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂         group;         d)

wherein: n² is an integer from 0 to 2, R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—; n′ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; e)

n² is 1, R¹³ is CH₃, Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n is 0, T₁ is —C(O)O— and U is a linear C₁-C₁₀ alkylene; e′)

wherein: n² is 1, R¹³ is CH₃; Y¹ is —(CH₂)_(n) ^(2′)—CH═CH— and n^(2′) is 0;

T₁=—O—C(O)—;

n¹ is 1 and U is a linear C₀-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; f)

wherein T₂ is —O— or —S—, —NH—, preferably T₂ is —O—, n³ is 1 or 2; when Y and Y′ are selected from d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T′-Y—ONO₂), -(T″-Y′—ONO₂), -(T′-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group.

Another embodiment of the invention relates to nitric oxide releasing compounds of general formula (I)

R-(Z)_(a)-R_(x)  (I)

and pharmaceutically acceptable salts or stereoisomers thereof for use in the treatment of respiratory diseases wherein in formula (I) the corticosteroid residue R is selected from:

a is 1 and Z is —C(O)—;

R_(X) is

(a1) —HN—CH(R′)—C(O)-(T-Y—ONO₂) wherein R¹ of the group A1) is selected from H, isobutyl, benzyl, C₆H₅—CH₂—CH₂—, 2-monosubstituted benzyl, or 3-monosubstituted benzyl or 4-monosubstituted benzyl wherein the substituent of the benzyl is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN, C₆H₅CO— or R¹ of the group A2) is selected from:

—CH₂—OH, —CH(CH₃)—OH— or —CH₂—[(C₆H₄)-(4-OH)], or

R¹ of the group A3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, or —C(O)CH₃, R¹ of the group A4) is —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl; T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, preferably T is —O—, Y is as below defined;

or R_(X) is

(a3) —HN—CH(R^(1a)-T″-Y′—ONO₂)—COOR^(3a) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)O— or —CH₂[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, R^(3a) is H or a (C₁-C₅) alkyl, T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, when R^(1a) is selected from the group A5) or A6), preferably T′ is —C(O)—; T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, when R^(1a) is selected from the group A7); Y′ is as below defined; or R_(X) is selected from. (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) (a6) —R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂) (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) or (a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1b) of the group A8) is selected from —O—CH(CH₃)—, —O—CH₂—, [-4-O)—(C₆H₄)]—CH₂—, or

R^(1b) of the group A9) is selected from —HN—CH₂—, —HN—(CH₂)₂—, —HN—(CH₂)₃—, —HN—(CH₂)₄—,

R^(3a) is H or a (C₁-C₅) alkyl, R^(4a) is H or —C(O)CH₃, T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, preferably T is —O—, T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ is —C(O)—, Y and Y′ are as below defined;

or R_(X) is

(a7) —HN—CH(R^(1a)-T″-Y′—ONO₂)—C(O)-(T-Y—ONO₂) wherein R^(1a) of the group A5) is selected from CH₂—O—, —CH(CH₃)—O— or —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—; T″ is —C(O)— or —C(O)—X″, wherein X″ is —S— or —O—, when R^(1a) is selected from A5) or A6), preferably T″ is —C(O)— T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—, wherein R′ is H or a straight or branched C₁-C₄ alkyl, when R^(1a) is selected from A7), preferably T″ is —O—, T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, preferably T is —O—; Y and Y′ are as below defined;

or R_(X) is

(b1) —HN—CH(R²)—CH₂—C(O)-(T-Y—ONO₂) wherein R² of the group B1) is selected from H, CH₃, isobutyl, isopropyl, benzyl; R² of the group B2) is selected from —CH₂—OH, —CH(CH₃)—OH— or —CH₂[(C₆H₄)(4-OH)], or R² of the group B3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, or —C(O)CH₃, R² of the group B4) is —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl; T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, preferably T is —O—, Y is as below defined; or R_(X) is selected from (d1) —HN—CH(R¹²)—CH₂—O-(T″′-Y—ONO₂) or (d2) —O—CH₂—CH(R¹²)—NH-(T′-Y—ONO₂) wherein R¹² of the group D1) is selected from H, CH₃, isobutyl, isopropyl, benzyl, or R¹² of the group D2) is selected from CH₂—OH, —CH(CH₃)OH— or —CH₂[(C₆H₄)-(4-OH)], or

R¹² of the group D3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″ wherein R″ is H, or

R¹² of the group D4) is —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl; T′ and T″′ are each independently selected from —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ and T″′ are —C(O)—, Y is as below defined; or R_(X) is selected from: (d3) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂OH (d4) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NHR^(4a)

-   -   (d7) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) or         (d8) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein         R^(12a) of the group D5) is selected from —CH₂—O—, —CH(CH₃)—O—         or —CH₂—[(C₆H₄)-(4-O)—], or         R^(12a) of the group D6) is selected from —CH₂—NH—, —(CH₂)₂—NH—,         —(CH₂)₃—NH—, —(CH₂)₄—NH—, or         R^(12a) of the group D7) is —CH₂—C(O)—, —(CH₂)₂—C(O)—,         —(CH₂)₄—C(O)—;

R^(4a) is H or —C(O)CH₃,

T″ is selected from —C(O)— or —C(O)—X″, wherein X″ is —S— or —O—, when R^(12a) is selected from D5) or D6), preferably T′ and T″′ are —C(O)—, T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—, wherein R′ is H or a straight or branched C₁-C₄ alkyl, when R^(12a) is selected from D7), preferably T is —O—, T″′ is selected from —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, preferably T″′ is —C(O)—, Y and Y′ are as below defined; or R_(X) is selected from: (d5) —R^(12b)—CH(NHR^(4a))—CH₂—O-(T″′-Y—ONO₂) (d6) —R^(12b)—CH(CH₂OH)—NH-(T′-Y—ONO₂) (d9) —R^(12b)—CH(NH-T′-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) or (d10) —R^(12b)—CH(CH₂—O-T″′-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(12b) of the group D8) is selected from —O—CH(CH₃)—, —O—CH₂—, [-4-O—(CH₄)]—CH₂—, or

R^(12b) of the group D9) is selected from —HN—CH₂—, —HN— (CH₂)₂—, —HN— (CH₂)₃—, —HN— (CH₂)₄—;

R^(4a) is H or —C(O)—CH₃.

T′ and T″′ are each independently selected from —C(O)—, —C(O)—X″, wherein X″ is —S— or —O—, preferably T′ and T″′ are —C(O)—, Y and Y′ are each independently selected from a)

-   -   a straight or branched C₁-C₁₀ alkylene,     -   a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂         group;         d)

wherein: n² is an integer from 0 to 2, R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—, n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; e)

n² is 1, R¹³ is CH₃, Y¹ is —CH═CH— (CH₂)_(n) ^(2′)— and n^(2′) is 0, T₁ is —C(O)O— and U is a linear C₁-C₁₀ alkylene; e′)

wherein: n² is 1, R¹³ is CH₃, Y¹ is —(CH₂)_(n) ^(2′)—CH═CH— and n^(2′) is 0,

T₁=—O—C(O)—,

n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; f)

wherein T₂ is —O— or —S—, —NH—, preferably T₂ is —O—, n³ is 1 or 2, when Y and Y′ are selected from d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T″-Y—ONO₂), -(T″-Y′—ONO₂), -(T″-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group.

Another embodiment of the present invention is to provide nitric oxide releasing compounds of general formula (I)

R-(Z)_(a)-R_(x)  (I)

and pharmaceutically acceptable salts or stereoisomers thereof for use in the treatment of respiratory diseases, wherein in formula (I) the corticosteroid residue R is selected from:

a is 0,

R_(X) is

(a2) —C(O)—CH(R¹)—NH-(T′-Y—ONO₂) wherein R¹ of the group A1) is H

T′ is —C(O)—;

Y is selected from a)

-   -   a straight or branched C₁-C₁₀ alkylene,     -   a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂         group;

Another embodiment relates to nitric oxide releasing compounds of general formula (I)

R-(Z)_(a)-R_(x)  (I)

and pharmaceutically acceptable salts or stereoisomers thereof for use in the treatment of respiratory diseases, wherein in formula (I) the corticosteroid residue R is selected from:

a is 0, R_(X) is selected from R_(X) is selected from

-   -   (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂)     -   (a6) —R^(1b)—CH(COOR^(1a))NH-(T′-Y—ONO₂) or     -   (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂)         wherein         R^(1b) of the group A10) is C(O)—CH₂—,         R^(3a) is H or a (C₁-C₅) alkyl,

R^(4a) is H or —C(O)CH₃,

T is selected from —O—, —S—, —NR′— wherein R′ is as above defined, T′ is —C(O)— and Y and Y′ are each independently selected from a)

-   -   a straight or branched C₁-C₁₀ alkylene,     -   a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂         group.

Another embodiment relates to nitric oxide releasing compounds of general formula (I)

R-(Z)_(a)-R_(X)  (I)

and pharmaceutically acceptable salts or stereoisomers thereof for use in the treatment of respiratory diseases, wherein in formula (I) the corticosteroid residue R is selected from:

a is 1 and Z is —C(O)—, R_(X) is

-   -   (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) or     -   (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂)         wherein R^(1b) of A10) is —O—CH₂— or [-4-O—(C₆H₄)]—CH₂—,

R^(4a) is H or —C(O)CH₃,

T is selected from —O—, —S—, —NR′— wherein R′ is as above defined,

T′ is —C(O)— and

Y and Y′ are each independently selected from a)

-   -   a straight or branched C₁-C₁₀ alkylene,     -   a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂         group.

Another embodiment of the invention relates to nitric oxide releasing compounds of general formula (I)

R-(Z)_(a)-R_(x)  (I)

and pharmaceutically acceptable salts or stereoisomers thereof for use in the treatment of respiratory diseases, wherein in formula (I) the corticosteroid residue R is selected from:

a is 0,

R_(X) is

(b2) —C(O)—CH₂—CH(R²)—NH-(T′-Y—ONO₂) wherein R² of the group B1) is H,

T′ is —C(O)—;

Y and Y′ are each independently selected from a)

-   -   a straight or branched C₁-C₁₀ alkylene,     -   a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂         group.

The most preferred nitric oxide releasing compounds of general formula (I) for the use in the treatment of respiratory diseases are:

Another object of the present invention provides nitric oxide releasing compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof

R-(Z)_(a)-R_(x)  (I)

wherein R is a corticosteroid residue selected from:

a is 0 or 1, Z is a group capable of binding R_(X) and is selected from —C(O)—, or —CH(R′)—O— wherein R′ is selected from H or a straight or branched C₁-C₄ alkyl, preferably R′ is H or —CH₃; R_(x) is a radical selected from the following meanings:

A)

-   -   (a1) —HN—CH(R¹)—C(O)-(T-Y—ONO₂)     -   (a2) —C(O)—CH(R¹)—NH-(T′-Y—ONO₂)     -   (a3) —HN—CH(R^(1a)-T′-Y′—ONO₂)—COOR^(3a)     -   (a4) —C(O)—CH(R^(1a)-T″-Y′—ONO₂)—NHR^(4a)     -   (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂)     -   (a6) —R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂)     -   (a7) —HN—CH(R^(1a)-T″-Y′—ONO₂)—C(O)-(T-Y—ONO₂)     -   (a8) —C(O)—CH(R^(1d)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂)     -   (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂)     -   (a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂)     -   wherein:     -   R¹ is selected from:         -   A1) H, —CH₃, isopropyl, isobutyl, sec-butyl, tert-butyl,             methylthio-(CH₂)₂—, phenyl, benzyl, C₆H₅—CH₂—CH₂—,             2-monosubstituted benzyl, or 3-monosubstituted benzyl or             4-monosubstituted benzyl wherein the substituent of the             benzyl is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN,             C₆H₅CO—;         -    2,4-dichlorobenzyl, 3,4-dichlorobenzyl, 3,4-difluorobenzyl,             2-pyrrolidyl, 3-triptophanyl-CH₂—, 3-benzothienyl-CH₂—,             4-imidazolyl-CH₂—, 9-anthranyl-CH₂—, cyclohexyl,             cyclohexyl-CH₂—, cyclohexyl-(CH₂)₂—, cyclopentyl-CH₂—,             (C₆H₅)₂CH—, 4-B(OH)₂-benzyl, 4-quinolyl-CH₂—,             3-quinolyl-CH₂—, 2-quinolyl-CH₂—, 2-quinoxalyl-CH₂—,             2-furyl-CH₂—, 1-naphtyl-CH₂—, 2-naphtyl-CH₂—,             2-pyridyl-CH₂—, 3-pyridyl-CH₂—, 4-pyridyl-CH₂—,             2-thienyl-CH₂—, 3-thienyl-CH₂—, C₆H₄—CH═CH—CH₂—,             CH₂═CH—CH₂—, CH≡CH—CH₂—, NH₂—CO—CH₂—, NH₂—CO—(CH₂)₂—,             NH₂(═NH)NH—(CH₂)₃—, P(═O)(OCH₃)₂, I—CH₂—, preferably R¹ is             H, —CH₃, isopropyl, benzyl;         -   A2) —CH₂—SH, —CH₂—OH, —CH(CH₃)—OH, —CH₂—[(C₆H₄)-(4-OH)],             —CH₂—[(C₆H₂)-(3,5-diiodo)-(4-OH)],             —CH₂—[(C₆H₃)-(3-nitro)-(4-OH)], preferably R¹ is —CH₂—OH or             —CH₂[(C₆H₄)-(4-OH)];         -   A3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″,             wherein R″ is H, —C(O)CH₃ or

-   -   -    wherein R^(5a) is H or a linear or branched C₁-C₁₀ alkyl             chain, preferably R^(5a) is H or a linear (C₁-C₅) alkyl,             preferably R¹ is —(CH₂)₄—NHR″, wherein R″ is as above             defined,         -   A4) —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein             R″′ is —OR^(5a) or

-   -   -    wherein R^(5a) is as above defined, preferably R¹ is             —CH₂—C(O)R″′, wherein R″′ is as above defined,

    -   R^(1a) is selected from:         -   A5) —CH₂—S—, —CH₂—O—, —CH(CH₃)—O—, —CH₂[(C₆H₄)-(4-O)—],             —CH₂-[(3,5-diiodo)-(C₆H₂)-(4-O)—],             —CH₂-[(3-nitro)-(C₆H₃)-(4-O)—], preferably R^(1a) is             —CH₂—O—;         -   A6) —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—,             preferably R^(1a) is —(CH₂)₄—NH— or —CH₂—NH—,         -   A7) —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, preferably             R^(1a) is —CH₂—C(O)—;

    -   R^(3a) is selected from H, —R^(5a) or

-   -   -   wherein R^(5a) is as above defined,

    -   R^(4a) is selected from H or —C(O)CH₃ or

-   -   wherein R^(5a) is as above defined,     -   R^(1b) is selected from         -   A8) —S—CH₂—, —O—CH(CH₃)—, —O—CH₂—, [-(4-O)—(C₆H₄)]—CH₂—,             [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂—,             [-(4-O)-(3-nitro)-(C₆H₃)]—CH₂—, preferably R^(1b) is —O—CH₂—             or [-(4-O)—(C₆H₄)]—CH₂—;         -   A9) —HN—CH₂—, —HN—(CH₂)₂—, —HN—(CH₂)₃—, —HN—(CH₂)₄—,             preferably R^(1b) is —HN—(CH₂)₄— or —HN—CH₂—;         -   A10) —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, preferably             R^(1b) is —C(O)—CH₂—;             T is selected from —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— or             —O—CH(R′)—O—C(O)O— wherein R′ is as above defined;             T′ is —C(O)—, —C(O)—X″— wherein X″ is —O— or —S—, or T′ is             —C(O)—NR′— wherein R′ is as above defined;             T″ is independently selected from —C(O)—, —C(O)—X″—,             —C(O)—NR′—, —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—,             —O—CH(R′)—O—C(O)O—, wherein X″ and R′ are as above defined,             with the proviso that T″ is —C(O)—, —C(O)—X″— or —C(O)—NR′—             when T″ is linked to —NH—, —O—, or —S—, or             T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—, —O—CH(R′)—O—C(O)O—             when T″ is linked to —C(O)—,             Y and Y′ are as below defined;             or R_(x) is selected from:

B)

(b1) —HN—CH(R²)—CH₂—C(O)-(T-Y—ONO₂)

(b2) —C(O)—CH₂—CH(R²)—NH-(T′-Y—ONO₂)

(b3) —HN—CH(R^(2a)-T″-Y′—ONO₂)—CH₂COOR^(3a)

(b4) —C(O)—CH₂—CH(R^(2a)-T″-Y′—ONO₂)—NHR^(4a)

(b5) —R^(2b)—CH(NHR^(4a))—CH₂—C(O)-(T-Y—ONO₂)

(b6) —R^(2b)—CH(CH₂COOR^(3a))NH—-(T′-Y—ONO₂)

(b7) —HN—CH(R^(2a)-T″-Y′—ONO₂)—CH₂—C(O)-(T-Y—ONO₂)

(b8) —C(O)—CH₂—CH(R^(2a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂)

(b9) —R^(2b)—CH(NH-T′-Y′—ONO₂)—CH₂C(O)-(T-Y—ONO₂)

(b10) —R^(2b)—CH(CH₂C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂)

wherein

R² is selected from:

B1) H, —CH₃, CF₃, isopropyl, isobutyl, sec-butyl, methylthio-(CH₂)₂—, phenyl, benzyl, 3-triptophanyl-CH₂—, NH₂—C(O)—CH₂—, NH₂—C(O)—(CH₂)₂—, NH₂(═NH)NH—(CH₂)₃—, tBuO—CH(CH₃)—, benzyl-O—CH₂—, 4-terbutoxy-benzyl, 4-phenylbenzyl, preferably R² is H, —CH₃, isopropyl, benzyl,

B2) —CH₂—SH, —CH₂—OH, —CH(CH₃)—OH, —CH₂—[(C₆H₄)-(4-OH)], —CH₂—[(C₆H₂)-(3,5-diiodo)-(4-OH)], —CH₂—[(C₆H₃)-(3-nitro)-(4-OH)];

B3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is as above defined, preferably R² is —(CH₂)₄—NHR″;

B4) —CH₂—C(O)—R″′, —(CH₂)₂—C(O)—R″′, —(CH₂)₄—C(O)—R″′ wherein R″′ is as above defined, preferably R² is —CH₂—C(O)—R″′;

R^(2a) is selected from:

B5) —CH₂—S—, —CH₂—O—, —CH(CH₃)—O— or —CH₂[(C₆H₄)-(4-O)—], —CH₂-[(3,5-diiodo)-(C₆H₂)-(4-O)—], —CH₂-[(3-nitro)-(C₆H₃)-(4-O)—], preferably R^(2a) is —CH₂—O—;

B6) —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, preferably R^(2a) is —(CH₂)₄—NH— or —CH₂—NH—;

B7) —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, preferably R^(2a) is —CH₂—C(O)—;

R^(2b) is selected from

B8) —S—CH₂—, —O—CH(CH₃)—, —O—CH₂—, [-(4-O)—(C₆H₄)]—CH₂—, [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂—, [-(4-O)-(3-nitro)-(C₆H₃)]—CH₂—, preferably R^(2b) is —O—CH₂— or [-(4-O)—(C₆H₄)]—CH₂—;

B9) —HN—CH₂—, —HN—(CH₂)₂—, —HN—(CH₂)₃—, —HN—(CH₂)₄—, preferably R^(2b) is —HN— (CH₂)₄— or —HN—CH₂—;

B10) —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, preferably R^(2b) is —C(O)—CH₂—;

R^(3a) and R^(4a) are as above defined; T, T′ and T″ are as above defined and Y and Y′ are as below defined; or R_(x) is selected from:

C)

(c1) —HN—(CH₂)_(b)—C(O)-(T-Y—ONO₂); (c2) —C(O)—(CH₂)_(b)—NH-(T′-Y—ONO₂) wherein b is an integer from 3 to 6, T and T′ are as above defined and Y and Y′ are as below defined;

D)

(d1) —HN—CH(R¹²)—CH₂—O-(T″′-Y—ONO₂) (d2) —O—CH₂—CH(R¹²)—NH-(T′-Y—ONO₂) (d3) —HN—CH(R^(12a)-T″-Y″—ONO₂)—CH₂OH (d4) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NHR^(4a) (d5) —R^(12b)—CH(NHR^(4a))—CH₂—O-(T″′-Y—ONO₂) (d6) —R^(12b)—CH(CH₂OH)—NH-(T′-Y—ONO₂) (d7) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) (d8) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) (d9) —R¹²—CH(NH-T′-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) (d10) —R¹²—CH(CH₂—O-T″′-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein T″′ is independently selected from —C(O)—, —C(O)X″— wherein X″ is —O— or —S—, or —C(O)—NR′— wherein R′ is as above defined; T′ and T″ are as above defined, Y and Y′ are as below defined; R¹² is selected from:

D1) H, —CH₃, isopropyl, isobutyl, sec-butyl, methylthio-(CH₂)₂—, benzyl, 3-triptophanyl-CH₂—, 4-imidazolyl-CH₂—, NH₂—CO—CH₂—, NH₂—CO—(CH₂)₂—, NH₂(═NH)NH—(CH₂)₃—, preferably R¹² is H;

D2) —CH₂—OH, —CH(CH₃)—OH, —CH₂[(C₆H₄)-(4-OH)], —CH₂—[(C₆H₃)-(3,5-diiodo)-(4-OH)], —CH₂—[(C₆H₃)-(3-nitro)-(4-OH)], preferably R¹² is —CH₂—OH or —CH₂[(C₆H₄)-(4-OH)];

D3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is as above defined, preferably R¹² is —(CH₂)₄—NHR″;

D4) —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is as above defined, preferably R¹² is —CH₂—C(O)R″′;

R^(12a) is selected from

D5) —CH₂—O—, —CH(CH₃)—O— or —CH₂[(C₆H₄)-(4-O)—], —CH₂-[3,5-diiodo-(C₆H₂)-(4-O)—], —CH₂-[3-nitro-(C₆H₃)-4-O—], preferably R^(12a) is CH₂—O— or —CH₂—[(C₆H₄)-(4-O)—],

D6) —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, preferably R^(12a) is —(CH₂)₄—NH— or —CH₂—NH—,

D7) —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, preferably R^(2a) is —CH₂—C(O)—,

R^(12b) is selected from

D8) —O—CH₂—, —O—CH(CH₃)—, [-(4-O)—(C₆H₄)]—CH₂—, [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂, [-(4-O)-(3-nitro)-(C₆H₃)]—CH₂—, preferably R¹² is —O—CH₂— or [-(4-O)—(C₆H₄)]—CH₂—;

D9) —HN—CH₂—, —HN—(CH₂)₂—, —HN—(CH₂)₃—, —HN—(CH₂)₄—, preferably R^(12b) is —HN— (CH₂)₄— or —HN—CH₂—;

-   -   D10) —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, preferably         R^(12b) is —C(O)—CH₂—;         R^(4a) is as above defined;         or R_(x) is selected from:

HE)

wherein c is equal to 0 or 1, d is an integer from 0 to 3 with the proviso that c is 0 or 1 when d is 0 and c is 0 when d is 1, 2 or 3, T and T′ are as above defined and Y is as below defined;

F)

(XI)

wherein e and f are equal to 0 or 1, with the proviso that f is 0 when e is 0 and f is 0 or 1 when e is 1, T and t′ are as above defined and y is as below reported;

G)

wherein R³ is H, CH₃, propyl, (C₆H₅)₂CH—, 1-naphtyl-CH₂—, benzyl, allyl, 2-bromobenzyl, 2-chlorobenzyl, 3-chlorobenzyl, 4-fluorobenzyl, 4-bromobenzyl, 4-methylbenzyl, preferably R³ is H, T and T′ are as above defined and Y is as below defined;

H)

wherein R⁴ is H, benzyl, 4-bromobenzyl, 2-bromobenzyl, T and T′ are as above defined and Y is as below defined;

I)

wherein R⁵ is H, R^(p) is H, or R⁵ and R when taken together are a double bond, T and T′ are as above defined and Y is as below reported;

L)

wherein T and T′ are as above defined and Y is as below reported;

M)

wherein T and T′ are as above defined and Y is as below reported;

N)

wherein c is as above defined, d is equal to 0 or 1, T and T′ are as above defined and Y is as below reported;

O)

wherein R⁷ is H, R⁸ is H, or R⁷ and R⁸ when taken together are a double bond, c is as above defined, T and T′ are as above defined and Y is as below reported;

P)

wherein T and T′ are as above defined and Y is as below reported;

Q)

wherein T and T′ are as above defined and Y is as below reported;

R)

wherein T and T′ are as above defined and Y is as below reported;

S)

wherein T and T′ are as above defined and Y is as below reported;

T)

wherein T and T′ are as above defined and Y is as below reported;

U)

wherein R⁹ and R¹⁰ are H, CH₃, R¹¹ is CH₃ or 4-piperidinyl with the proviso that R⁹ and R¹⁰ are H when R¹¹ is 4-piperidinyl and R⁹ and R¹⁰ are CH₃ when R¹¹ is CH₃, T and T′ are as above defined and Y is as below reported;

V)

wherein T and T′ are as above defined and Y is as below reported; with the proviso that in the formula (I): a is 0 or a is 1 and Z is —CH(R′)—O— wherein R′ is as above defined, when R_(X) is:

(a2), (a4) or (a8);

(a5), (a6), (a9) or (a10) and R^(1b) is selected from the group A10);

(b2), (b4) or (b8);

(b5), (b6), (b9) or (b10) and R^(2b) is selected from the group B10);

(c2);

(d5), (d6), (d9) or (d10) and R^(12b) is selected from the group D10);

(e2), (f1), (g2), (h1), (i1), (l2), (m2), (n2), (o2), (p2), (q2), (r2), (s2), (t1) or (u2);

a is 1 and Z is —C(O)—, when R_(X) is:

(a1), (a3) or (a7);

(a5), (a6), (a9) or (a10) and R^(1b) is selected from the groups A8) and A9);

(b1), (b3) or (b7);

(b5), (b6), (b9) or (b10) and R^(2b) is selected from the groups B8) or B9);

(c1);

(d1), (d2), (d3), (d4), (d7) or (d8);

(d5), (d6), (d9) or (d10) and R^(12b) is selected from the groups D8) or D9);

(e1), (f2), (g1), (h2), (i2), (l1), (m1), (n1), (o1), (p1), (q1), (r1), (s1), (t2) or (u1).

Y and Y′ are bivalent radicals each independently selected from the following meanings: a)

straight or branched C₁-C₂₀ alkylene, preferably a straight or branched C₁-C₁₀ alkylene,

straight or branched C₁-C₂₀ alkylene substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, —ONO₂ or T₂, wherein T₂ is —OC(O)(C₁-C₁₀ alkyl)-ONO₂ or O(C₁-C₁₀ alkyl)-ONO₂, preferably Y or Y′ is a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group;

cycloalkylene with 5 to 7 carbon atoms into cycloalkylene ring, the ring being optionally substituted with one or more straight or branched C₁-C₁₀ alkyl chains, preferably the ring being optionally substituted with CH₃;

b)

wherein n⁰ is an integer from 0 to 20, preferably n^(C) is 0 or 1; n¹ is 0 or 1, preferably n′ is 1; U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group, preferably U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a ONO₂ group; c)

wherein n⁰ is an integer from 0 to 20, preferably n^(C) is 0 or 1; n¹ is 0 or 1, preferably n′ is 1;

U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group, preferably U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group;

d)

wherein: n² is an integer from 0 to 2, R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—; n¹ and U are as above defined; e)

n² is an integer from 0 to 2, preferably n² is 1; R¹³ is H or CH₃, preferably R¹³ is CH₃; Y¹ is —CH₂—CH₂— or —CH═CH—(CH₂)_(n) ^(2′)—, wherein n^(2′) is 0 or 1, preferably Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n^(2′) is 0; T₁=—O—C(O)— or —C(O)O—, preferably T₁ is —C(O)O—; n¹ is 0 or 1, preferably n¹ is 1; U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group, preferably U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a ONO₂ group; more preferably n² is 1, R¹³ is CH₃, Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n^(2′) is 0, T₁ is —C(O)O— and U is a linear C₁-C₁₀ alkylene; e′)

wherein: n² is an integer from 0 to 2, preferably n² is 1; R¹³ is H or CH₃, preferably R¹³ is CH₃; Y¹ is —CH₂—CH₂— or —(CH₂)₂—CH═CH—, wherein n is 0 or 1, preferably Y¹ is —(CH₂)_(n) ^(2′)—CH═CH— and n^(2′) is 0;

T₁=—O—C(O)—;

n¹ is 0 or 1, preferably n¹ is 1; U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group, preferably U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; more preferably n² is 1, R¹³ is CH₃, Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n^(2′) is 0, T₁ is —OC(O)— and U is a linear C₁-C₁₀ alkylene; f)

wherein T₂ is —O— or —S—, —NH—, preferably T₂ is —O—, n³ is an integer from 1 to 6, preferably n³ is 1; when Y and Y′ are selected from b), c), d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T′-Y—ONO₂), -(T″-Y′—ONO₂), -(T′-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group; g)

wherein: n⁴ is an integer from 0 to 10, preferably n⁴ is 0 or 1; n⁵ is an integer from 1 to 10, preferably n⁵ is 1;

R¹⁴, R¹⁵, R¹⁶, R¹⁷ are the same or different, and are H or straight or branched C₁-C₄ alkyl, preferably R¹⁴, R¹⁵, R¹⁶ and R¹⁷ are H;

wherein the —ONO₂ group is linked to

wherein n⁵ is as defined above;

Y² is an heterocyclic saturated, unsaturated or aromatic 5 or 6 members ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulphur, and is selected from the group consisting of:

Another object of the present invention provides nitric oxide releasing compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof

R-(Z)_(a)-R_(x)  (I)

wherein R is a corticosteroid residue selected from:

a is 0 and R_(X) is selected from: (a2) —C(O)—CH(R¹)—NH-(T′-Y—ONO₂) wherein R¹ of the group A1) is selected from H, isobutyl, benzyl, C₆H₅—CH₂—CH₂—, 2-monosubstituted benzyl, or 3-monosubstituted benzyl or 4-monosubstituted benzyl wherein the substituent of the benzyl is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN, C₆H₅CO—; R¹ of the group A2) is selected from —CH₂—OH, —CH(CH₃)OH— or —CH₂[(C₆H₄)-(4-OH)], or R¹ of the group A3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, or —C(O)CH₃; R¹ of the group A4) is selected from —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl; T′ is —C(O)—, —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ is —C(O)—; Y is as below defined;

or R_(X) is

(a4) —C(O)—CH(R^(1a)-T″-Y′—ONO₂)—NHR^(4a) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)O— or —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—, (CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is selected from —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—,

R^(4a) is H or —C(O)CH₃,

T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, when R^(1a) is selected from the group A5) or A6), preferably T″ is —C(O)—; T″ is —O—, —S—, —NR′— or —O—CH(R′)—O—C(O)— wherein R′ is H or —CH₃, when R^(1a) is selected from the group A7), Y′ is as below defined; or R_(X) is selected from: (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) (a6) —R^(1b)—CH(COOR^(3a))NH-(T′—Y—ONO₂) (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) or (a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1b) of the group A10) is selected from —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, R^(3a) is H or a (C₁-C₅) alkyl,

R^(4a) is H or C(O)CH₃,

T is —O—, —S—, —NR′— or —O—CH(R′)—O—C(O)— wherein R′ is H or —CH₃, preferably T is —O—, T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ is —C(O)—, Y and Y′ are as below defined;

or R_(X) is

(a8) —C(O)—CH(R^(1a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)—O— or —CH₂[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is selected from —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, when R^(1a) is selected from the group A5) or A6), preferably T″ is —C(O)—, T″ is —O—, —S—, —NR′— or —O—CH(R′)—O—C(O)— wherein R′ is H or —CH₃, when R^(1a) is selected from the group A7); T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ is —C(O)—, Y and Y′ are as below defined,

or R_(X) is

(b2) —C(O)—CH₂—CH(R²)—NH-(T′-Y—ONO₂) wherein R² of the group B1) is selected from H, CH₃, isobutyl, isopropyl, benzyl; T′ is —C(O)—, —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ is —C(O)—; Y and Y′ are each independently selected from a)

a straight or branched C₁-C₁₀ alkylene,

a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group;

d)

wherein: n² is an integer from 0 to 2, R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—; n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; e)

n² is 1, R¹³ is CH₃, Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n^(2′) is 0, T₁ is —C(O)O— and U is a linear C₁-C₁₀ alkylene; e′)

wherein: n² is 1, R¹³ is CH₃; Y¹ is —(CH₂)_(n) ^(2′)—CH═CH— and n^(2′) is 0;

T₁=—O—C(O)—;

n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; f)

wherein T₂ is —O— or —S—, —NH—, preferably T₂ is —O—, n³ is 1 or 2; when Y and Y′ are selected from d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T′-Y—ONO₂), -(T″-Y′—ONO₂), -(T′-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group.

Another object of the present invention provides nitric oxide releasing compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof

R-(Z)_(a)-R_(x)  (I)

wherein R is a corticosteroid residue selected from:

a is 1 and Z is —C(O)—; R_(X) is

(a1) —HN—CH(R¹)—C(O)-(T-Y—ONO₂) wherein R¹ of the group A1) is selected from H, isobutyl, benzyl, C₆H₅—CH₂—CH₂—, 2-monosubstituted benzyl, or 3-monosubstituted benzyl or 4-monosubstituted benzyl wherein the substituent of the benzyl is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN, C₆H₅CO— or R¹ of the group A2) is selected from:

—CH₂—OH, —CH(CH₃)—OH— or —CH₂[(C₆H₄)-(4-OH)], or

R¹ of the group A3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, or —C(O)CH₃, R¹ of the group A4) is —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₃-C₅) alkyl; T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, preferably T is —O—, Y is as below defined;

or R_(X) is

(a3) —HN—CH(R^(1a)-T″-Y′—ONO₂)—COOR^(3a) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)O— or —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, R^(3a) is H or a (C₁-C₅) alkyl, T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, when R^(1a) is selected from the group A5) or A6), preferably T″ is —C(O)—; T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, when R^(1a) is selected from the group A7); Y¹ is as below defined; or R_(X) is selected from. (a5) —R^(1b)—OCH(NHR^(4a))—C(O)-(T-Y—ONO₂) (a6) —R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂) (a9) —R^(1b)—OCH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) or (a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1b) of the group AB) is selected from —O—CH(CH₃)—, —O—CH₂—, [-4-O)—(C₆H₄)]—CH₂—, or R^(1b) of the group A9) is selected from —HN—CH₂—, —HN—(CH₂)₂—, —HN— (CH₂)₃—, —HN— (CH₂)₄—, R^(3a) is H or a (C₁-C₅) alkyl,

R^(4a) is H or —C(O)CH₃,

T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, preferably T is —O—, T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ is —C(O)—, Y and Y′ are as below defined;

or R_(X) is

(a7) —HN—CH(R^(1a)-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)—O— or —CH₂[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—; T″ is —C(O)— or —C(O)—X″, wherein X″ is —S— or —O—, when R″ is selected from A5) or A6), preferably T″ is —C(O)—; T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—, wherein R′ is H or a straight or branched C₁-C₄ alkyl, when R^(1a) is selected from A7), preferably T″ is —O—, T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, preferably T is —O—; Y and Y′ are as below defined;

or R_(X) is

(b1) —HN—CH(R²)—CH₂—C(O)-(T-Y—ONO₂) wherein R² of the group B1) is selected from H, CH₃, isobutyl, isopropyl, benzyl; R² of the group B2) is selected from —CH₂—OH, —CH(CH₃)—OH— or —CH₂—[(C₆H₄)(4-OH)], or R² of the group B3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, or —C(O)CH₃, R² of the group B4) is —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl; T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, preferably T is —O—, Y is as below defined; or R_(X) is selected from (d1) —HN—CH(R¹²)—CH₂—O-(T″′-Y—ONO₂) or (d2) —O—CH₂—CH(R¹²)—NH-(T′-Y—ONO₂) wherein R¹² of the group D1) is selected from H, CH₃, isobutyl, isopropyl, benzyl, or R¹² of the group D2) is selected from —CH₂—OH, —CH(CH₃)OH— or —CH₂[(C₆H₄)-(4-OH)], or R¹² of the group D3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″ wherein R″ is H, or R¹² of the group D4) is —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl; T′ and T″′ are each independently selected from —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, preferably T′ and T″′ are —C(O)—, Y is as below defined; or R_(X) is selected from: (d3) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂OH (d4) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NHR^(4a) (d7) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) or (d8) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(12a) of the group D5) is selected from —CH₂—O—, —CH(CH₃)—O— or —CH₂[(C₆H₄)-(4-O)—], or R^(12a) of the group D6) is selected from —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(12a) of the group D7) is —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—;

R^(4a) is H or —C(O)CH,

T″ is selected from —C(O)— or —C(O)—X″, wherein X″ is —S— or —O—, when R^(12a) is selected from D5) or D6), preferably T′ and T″′ are —C(O)—, T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—, wherein R′ is H or a straight or branched C₁-C₄ alkyl, when R^(12a) is selected from D7), preferably T is —O—, T″′ is selected from —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, preferably T″′ is —C(O)—, Y and Y′ are as below defined; or R_(X) is selected from: (d5) —R^(12b)—CH(NHR^(4a))—CH₂—O-(T″′-Y—ONO₂) (d6) —R^(12b)—CH(CH₂OH)—NH-(T′-Y—ONO₂) (d9) —R^(12b)—CH(NH-T′-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) or (d10) —R^(12b)—CH(CH₂—O-T″′-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(12b) of the group D8) is selected from —O—CH(CH₃)—, —O—CH₂—, [-4-O—(C₈H₄)]-CH₂—, or R^(12b) of the group D9) is selected from —HN—CH₂—, —HN—(CH₂)₂—, —HN— (CH₂)₃—, —HN—(CH₂)₄—;

R^(4a) is H or —C(O)—CH₃,

T′ and T″′ are each independently selected from —C(O)—, —C(O)—X″, wherein X″ is —S— or —O—, preferably T′ and T″′ are —C(O)—, Y and Y′ are each independently selected from a)

a straight or branched C₁-C₁₀ alkylene,

a straight or branched C₁-C₁₀ alkylene substituted with a ONO₂ group;

d)

wherein: n² is an integer from 0 to 2, R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—, n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; e)

n² is 1, R¹³ is CH₃, Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n^(2′) is 0, T₁ is —C(O)O— and U is a linear C₁-C₁₀ alkylene; e′)

wherein: n² is 1, R¹³ is CH₃, Y¹ is —(CH₂)_(n) ^(2′)—CH═CH— and n^(2′) is 0,

T₁=—O—C(O)—,

n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; f)

wherein T₂ is —O— or —S—, —NH—, preferably T₂ is —O—, n³ is 1 or 2, when Y and Y′ are selected from d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T′-Y—ONO₂), -(T″-Y′—ONO₂), -(T′-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group.

Another object of the present invention provides nitric oxide releasing compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof

R-(Z)_(a)-R_(x)  (I)

wherein R is a corticosteroid residue selected from:

a is 0,

R_(X) is

(a2) —C(O)—CH(R¹)—NH-(T′-Y—ONO₂) wherein R¹ of the group A1) is H

T′ is —C(O)—;

Y is selected from a)

a straight or branched C₁-C₁₀ alkylene,

a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group;

Another object of the present invention provides nitric oxide releasing compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof

R-(Z)_(a)-R_(x)  (I)

wherein R is a corticosteroid residue selected from:

a is 0, R_(X) is selected from R_(X) is selected from

(a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂)

(a6) —R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂) or

(a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂)

wherein R^(1b) of the group A10) is —C(O)—CH₂—, R^(3a) is H or a (C₁-C₅) alkyl,

R^(4a) is H or —C(O)CH₃,

T is selected from —O—, —S—, —NR′— wherein R′ is as above defined,

T′ is —C(O)— and

Y and Y′ are each independently selected from a)

a straight or branched C₁-C₁₀ alkylene,

a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group.

Another object of the present invention provides nitric oxide releasing compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof

R-(Z)_(a)-R_(x)  (I)

wherein R is a corticosteroid residue selected from:

a is 1 and Z is —C(O)—, R_(X) is

(a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) or

(a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂)

wherein R^(1b) of A10) is —O—CH₂— or [-4-O—(C₆H₄)]—CH₂—,

R^(4a) is H or —C(O)CH₃,

T is selected from —O—, —S—, —NR′— wherein R′ is as above defined,

T′ is —C(O)— and

Y and Y′ are each independently selected from a)

a straight or branched C₁-C₁₀ alkylene,

a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group.

Another object of the present invention provides nitric oxide releasing compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof

R-(Z)_(a)-R_(x)  (I)

wherein R is a corticosteroid residue selected from:

a is 0,

R_(X) is

(b2) —C(O)—CH₂—CH(R²)—NH-(T′-Y—ONO₂) wherein R² of the group B1) is H,

T′ is —C(O)—;

Y and Y′ are each independently selected from a)

a straight or branched C₁-C₁₀ alkylene,

a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group.

The most preferred nitric oxide releasing compounds of general formula (I) are:

Another object of the invention is a composition comprising a compound of formula (I) above reported and at least one bronchodilator or a pharmaceutical acceptable salt or solvate thereof.

Bronchodilators that can be used in the composition of the invention include: anticholinergic bronchodilators which includes tiotropium and ipratropium, β₂-agonists which include salbutamol, bitolterol mesylate, formoterol, isoproterenol, levalbuterol, metaproterenol, salmeterol, terbutaline and fenoterol. In addition to β₂-agonists and anticholinergics, other bronchodilator that may be used in the composition of the present invention are ephedrine and xanthines. Representative xanthines include theophylline, aminophylline and oxtriphyline.

In another embodiment, the compound of formula (I) and at least one bronchodilator are administered simultaneously wherein the two components may be administered by the same or different administration pathways.

In another embodiment, the compound of formula (I) and at least one bronchodilator are administered sequentially wherein the compound of formula (I) may be administered before or after the bronchodilator and the two components may be administered by the same or different administration pathways.

In another embodiment the invention provides the use of a composition comprising a compound of formula (I) above reported and at least one bronchodilator or a pharmaceutical acceptable salt or solvate thereof in the treatment of respiratory diseases which comprise asthma, COPD (chronic obstructive pulmonary diseases), ARDS (Acute Respiratory Distress Syndrome), allergic rhinitis and respiratory tract diseases associated with inflammation.

As stated above, the invention includes also the pharmaceutically acceptable salts of the compounds of formula (I) and stereoisomers thereof.

Examples of pharmaceutically acceptable salts are either those with inorganic bases, such as sodium, potassium, calcium and aluminium hydroxides, or with organic bases, such as lysine, arginine, triethylamine, dibenzylamine, piperidine and other acceptable organic amines.

The compounds according to the present invention, when they contain in the molecule one salifiable nitrogen atom, can be transformed into the corresponding salts by reaction in an organic solvent such as acetonitrile, tetrahydrofuran with the corresponding organic or inorganic acids.

Examples of organic acids are: oxalic, tartaric, maleic, succinic, citric acids. Examples of inorganic acids are: nitric, hydrochloric, sulphuric, phosphoric acids. Salts with nitric acid are preferred.

The compounds of the invention which have one or more asymmetric carbon atoms can exist as optically pure enantiomers, pure diastereomers, enantiomers mixtures, diastereomers mixtures, enantiomer racemic mixtures, racemates or racemate mixtures. Within the object of the invention are also all the possible isomers, stereoisomers and their mixtures of the compounds of formula (I).

The compounds of the present invention are formulated in the corresponding pharmaceutical compositions, also with belated release, for parenteral, oral and topic use, such as for example inhalatory, suppository, transdermal, according to the well known techniques in the art, together with the usual excipients; see for example the publication “Remington's Pharmaceutical Sciences” 15^(th) Ed.

The amount on a molar basis of the active principle in said compositions is generally the same, or lower than that of the corresponding precursor drug.

The daily administrable doses are those of the precursor drugs, or optionally lower. The precursor daily doses can be found in the publications of the field, such for example in the “Physician's Desk reference”.

Synthesis Procedure

1) The compounds of general formula (I) as above defined wherein a is equal to 0, the radical R_(X) is selected from (a2), (a4), (a8), (b2), (b4), (b8), (c2), (e2), (f1), (g2), (h1), (i1), (l2), (m2), (n2), (o2), (p2), (q2), (r2), (s2), (t2), (u2), (v2), can be obtained: 1-i) by reacting a compound of formula (II₁)

R—H  (II₁)

wherein R is as defined above, with a compound of formula (Ia)

W—X₁  (Ia)

wherein W is —OH, Cl, O—R_(a) wherein R_(a) is pentafluorophenyl, 4-nitrophenyl or —(N-succimidyl), X₁ is as below defined, to obtain the compounds of formula (II₂)

R—X₁  (II₂)

wherein X₁ is as below defined, X₁ is a radical having the following meaning:

(a2′) —C(O)—CH(R^(1′))—NH-(T′-Y-Q)

wherein R″ is selected from A1) as defined above or A2′) —CH₂—SP¹, —CH₂—OP¹, —CH(CH₃)—OP¹, —CH₂—[(C₆H₄)-4-OP¹], —CH₂—[(C₆H₃)-(3,5-diiodo)-4-OP¹], —CH₂—[(C₆H₃)-3-nitro-4-OP¹] or

A3′) —CH₂—NHR″″, —(CH₂)₂—NHR″″, —(CH₂)₃—NHR″″, —(CH₂), —NHR″″,

wherein R″″ is P³ or —C(O)CH₃ or

wherein R^(5a) is as defined above;

A4′) —CH₂—C(O)R″″′, —(CH₂)₂—C(O)R″″′, —(CH₂)₄—C(O)R″″′

wherein R″″′ is P², —OR^(5a) or

wherein R^(5a) is as above defined;

(a4′) —C(O)—CH(R^(1a)-T″-Y′-Q)-NHR^(4a′)

(a8′) —C(O)—CH(R^(1a)-T″-Y′-Q)-NH-(T′-Y-Q)

wherein R^(1a) is as defined above and R^(4a) is P³ or —C(O)—CH₃ or

(b2′) —C(O)—CH₂—CH(R^(2′))—NH-(T′-Y-Q)

wherein R^(2′) is selected from B1) as defined above or

B2′) —CH(CH₃)—OP¹, —CH₂—[(C₆H₄)-4-OP¹]; B3′) —CH₂—NHR″″, —(CH₂)₂—NHR″″, —(CH₂), —NHR″″, —(CH₂)₄—NHR″″,

wherein R″″ is as above defined; B4′) —CH₂—C(O)—R″″′, —(CH₂)₂—C(O)—R″″′, —(CH₂)₄—C(O)—R″″′ wherein R″″′ is as above defined;

(b4′) —C(O)—CH₂—CH(R^(2a)-T″-Y′-Q)-NHR^(4a′)

(b8′) —C(O)—CH₂—CH(R^(2a)-T″-Y′-Q)-NH-(T′-Y-Q) wherein R^(2a) and R^(4a′) are as defined above;

(c2′) —C(O)—(CH₂)_(b)—NH-(T′-Y-Q);

wherein R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, b, c, d, e and f are as above defined; wherein P¹ is a hydroxyl or thiol protecting group such as silyl ethers, such as trimethylsilyl, tert-butyl-dimethylsilyl or trityl and those described in T. W. Greene “Protective groups in organic synthesis”, Harvard University Press, 1980, P2 is a carboxylic protecting group such as tert-butyl ester and those described in T. W. Greene “Protective groups in organic synthesis”, Harvard University Press, 1980, P³ is a amino protecting group such as Boc, Fmoc or those described in T. W. Greene “Protective groups in organic synthesis”, Harvard University Press, 1980, T, T′, T″, Y and Y′ are as above defined, Q is independently —ONO₂ or Z₂ wherein Z₂ is selected from the group consisting of: a chlorine atom, a bromine atom, a iodine atom, a mesyl group or a tosyl group, and 1-ii) when Q is Z₂, by converting the compound obtained in the step 1-i) into nitro derivative by reaction with a nitrate source such as silver nitrate, lithium nitrate, sodium nitrate, potassium nitrate, magnesium nitrate, calcium nitrate, iron nitrate, zinc nitrate or tetraalkylammonium nitrate (wherein alkyl is C₁-C₁₀ alkyl) in a suitable organic solvent such as acetonitrile, tetrahydrofurane, methyl ethyl ketone, ethyl acetate, DMF, the reaction is carried out, in the dark, at a temperature from room temperature to the boiling temperature of the solvent. Preferred nitrate source is silver nitrate and 1-iii) optionally deprotecting the compounds obtained in step 1-i) or 1-ii) as described in T. W. Greene “Protective groups in organic synthesis”, Harvard University Press, 1980, 2^(nd) edition. Fluoride ion is the preferred method for removing silyl ether protecting group. Trifluoroacetic acid or anhydrous inorganic acid are the preferred method for removing Boc protecting group, anhydrous organic or inorganic acid is the preferred method for removing trityl protecting group. Organic base such as piperidine is the preferred method for removing Fmoc protecting group. Aqueous or anhydrous organic or inorganic acid is the preferred method for removing t-butyl ester protecting group. 1-i-1) The reaction of a compound of formula (Ia) wherein W=—OH and X₁ is as above defined, with a compound of formula (II₁) may be carried out in presence of a condensing agent as dicyclohexylcarbodiimide (DCC), N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDAC) N,N′-carbonyldiimidazole (CDI), in the presence or not of a base as for example as N,N-dimethylamino pyridine (DMAP).

The reaction is carried out in an inert organic dry solvent such as N,N′-dimethylformamide, tetrahydrofuran, benzene, toluene, dioxane, a polyhalogenated aliphatic hydrocarbon at a temperature from −20° C. to 50° C. The reaction is completed within a time range from 30 minutes to 36 hours.

1-i-2) The reaction of a compound of formula (Ia) wherein W=—O—R_(a) wherein R_(a) and X₁ are as above defined, with a compound of formula (II₁) may be carried out in presence of a catalyst, such as N,N-dimethylamino pyridine (DMAP) or in the presence of DMAP and a Lewis acid such as Sc(OTf)₃ or Bi(OTf)₃.

The reaction is carried out in an inert organic solvent such as N,N′-dimethylformamide, tetrahydrofuran, benzene, toluene, dioxane, a polyhalogenated aliphatic hydrocarbon at a temperature from −20° C. to 40° C. The reaction is completed within a time range from 30 minutes to 36 hours.

1-i-3) The reaction of a compound of formula (Ia) wherein W=—Cl, and X₁ is are as above defined, with a compound of formula (II₁) may be carried out in presence of an organic base such as N,N-dimethylamino pyridine (DMAP), triethylamine, pyridine. The reaction is carried out in an inert organic solvent such as N,N′-dimethylformamide, tetrahydrofuran, benzene, toluene, dioxane, a polyhalogenated aliphatic hydrocarbon at a temperature from −20° C. to 40° C. The reaction is completed within a time range from 30 minutes to 36 hours.

The compounds of formula (II₁) are commercially available.

1a) The compounds of formula (Ia) wherein W is —OH, and X₁ is the radical selected from (a2′), (a4′), (b2′), (b4′), (c2′), (e2′), (f1′), (g2′), (h1′), (i1′), (l2′), (m2′), (n2′), (o2′), (p2′), (q2′), (r2′), (s2′), (t2′), (u2′), (v2′), wherein R^(1′) is selected from A1), A2′), A3′) or A4′), R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6) and R^(2′) is selected from B1), B2′), B3′) or B4′), wherein T′ and T″ are C(O) and Y, Y′ and R^(4a′) are as above defined, can be obtained 1a-i) by reacting a compound of formula (IIIa)

P²—X₂  (IIIa)

wherein P² is as above defined, X₂ is a radical having the following meaning

(a2″) —C(O)—CH(R^(1′))—NH₂

(a4″) —C(O)—CH(R^(1a)—H)—NHR^(4a′)

wherein R^(1′) is selected from A1), A2′), A3′), A4′), R^(1a) is selected from A5) or A6) and R^(4a′) is as defined above

(b2″) —C(O)—CH₂—CH(R²)—NH₂,

(b4″) —C(O)—CH₂—CH(R^(2a)—H)—NHR^(4a′)

wherein R^(2′) is selected from B1), B2′), B3′), B4′), R^(2a) is selected from B5) or B6) and R^(4a′) is as defined above,

(c2″) —C(O)—(CH₂)_(b)—NH₂,

wherein R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, b, c, d, e and f are as above defined; with a compound of formula (IVa)

W₁—(O)C-y-Q  (IVa)

wherein W₁ is OH or O—R_(a) and R_(a) and Q are as above defined, y is the radical Y when X₂ is selected from (a2′), (b2′), (c2′), (e2′), (f1′), (g2′), (h1′), (i1′), (l2′), (m2′), (n2′), (o2′), (p2′), (q2′), (r2′), (s2′), (t2′), (u2′), (v2′), and y is the radical Y′ when X₂ is selected from (a4′) or (b4′), wherein Y and Y′ are as defined above, and 1a-ii) when Q is Z₂, by converting the compound obtained in the step 1a-i) into nitro derivative by reaction with a nitrate source as above described and 1a-iii) optionally deprotecting the compounds obtained in step 1a-i) or 1a-ii) as above described.

The reaction of a compound of formula (IIIa) wherein P² and X₂ are as above defined, with a compound of formula (IVa) wherein W₁ is OH, y, Q are as above defined, may be carried out as described in 1-i-1) or in presence of other known condensing reagents such as O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU).

The reaction of a compound of formula (IIIa) wherein P² and X₂ are as above defined, with a compound of formula (IVa) wherein W₁ is O—R_(a), y, Q are as above defined, may be carried as described in 1-i-2).

The compounds of formula (IIIa) are commercially available or can be obtained as known in the literature.

The compounds of formula (IVa) wherein W₁ is OH, y and Q are as above defined, can be obtained from the corresponding alcohols of formula HOOC-y-OH (IVb) by reaction with nitric acid and acetic anhydride in a temperature range from −50° C. to 0° C. or from the corresponding derivatives of formula HOOC-y-Z₂ (IVc) wherein Z₂ is as above defined, by reaction with a nitrate source as above described. Alternatively the reaction with AgNO₃ can be performed under microwave irradiation in solvents such acetonitrile or THF at temperatures in the range between 100 and 180° C. for time range from 1 to 60 min.

The compounds of formula (IVb) are commercially available.

The compounds of formula (IVc) are commercially available or can be obtained as known in the literature.

The compounds of formula (IVa) wherein W₁ is O—R_(a), y, Q are as above defined, can be obtained from the corresponding acids of formula (IVa) wherein W₁ is OH as known in the literature.

The compounds of formula (Ia) wherein W═Cl or O—R_(a), X₁ is selected from (a2′), (a4′), (b2′), (b4′), (c2′), (e2′), (f1′), (g2′), (h1′), (i1′), (l2′), (m2′), (n2′), (o2′), (p2′), (q2′), (r2′), (s2′), (t2′), (u21), (v2′), wherein R″ is selected from A1), A2′), A3′) or A4′), R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6) and R^(2′) is selected from B1), B2′), B3′) or B4′), and wherein Y, Y′ and Q are as above defined and T′ and T″ are C(O), can be obtained from the corresponding acids (Ia) wherein W is —OH as known in the literature.

1b) The compounds of formula (Ia) wherein W is —OH, X₁ is the radical selected from (a2′), (a4′), (b2′), (b4′) (c2′), (e2′), (f1′), (g2′), (h1′), (i1′), (l2′), (m2′), (n2′), (o2′), (p2′), (q2′), (r2′), (s2′), (t2′), (u2′), (v2′), wherein R^(1′) is selected from A1), A2′), A3′) or A4′), R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6) and R^(2′) is selected from B1), B2′), B3′) or B4′), Y and Y′ are as above defined, T′ and T″ are C(O)—X″, wherein X″ is —O— or —S— can be obtained 1b-i) by reacting a compound of formula (IIIa)

P²—X₂  (IIIa)

wherein P² and X₂ are as defined above, with a compound of formula (IVd)

R_(a)—O—C(O)—X″-y-Q (IVd)

wherein R_(a), X″ and Q are as above defined, y is the radical Y when X₂ is selected from (a2′), (b2′), (c2′), (e2′), (f1′), (g2′), (h1′), (i1′), (l2′), (m2′), (n2′), (o2′), (p2′), (q2′), (r2′), (s2′), (t2′), (u2′), (v2′), and y is the radical Y′ when X₂ is selected from (a4′) or (b4′), wherein Y and Y′ are as above defined, and

1b-ii) when Q is Z₂, by converting the compound obtained in the step 1b-i) into nitro derivative by reaction with a nitrate source as above described and 1b-iii) optionally deprotecting the compounds obtained in step 1b-i) or 1b-ii) as above described.

The reaction of a compound of formula (IIIa) wherein P² and X₂ are as above defined, with a compound of formula (IVd) wherein R_(a), X″, y and Q are as above defined, may be carried out as described in 1-i-2)

The compounds of formula (IVd) wherein R_(a), X″, y, Q are as above defined, can be obtained from the compounds of formula HX″-y-Q (IVe) wherein X″, y, Q are as above defined, as known in literature.

The compounds of formula (IVe) are commercially available or are known in literature.

The compounds of formula (Ia) wherein W is —Cl or O—R_(a), X₁ is selected from (a2′), (a4′), (b2′), (b4′), (c2′), (e2′), (f1′), (g2′), (h1′), (i1′), (l2′), (m2′), (n2′), (o2′), (p2′), (q2′), (r2′), (s2′), (t2′), (u2′), (v2′), wherein R^(1′) is selected from A1), A2′), A3′), A4′), R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6) and R^(2′) is selected from B1), B2′), B3′), B4′), Y, Y′ and Q are as above defined, T′ and T″ are C(O)—X″ wherein X″ is O or S, can be obtained from the corresponding acids (Ia) wherein W is —OH as known in the literature.

1c) The compounds of formula (Ia) wherein W is —OH and X₁ is a radical selected from (a8′) or (b8′), wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6), Q is as above defined, T′ and T″ are C(O), Y and Y′ are the same and are as above defined, can be obtained 1c-i) by reacting a compound of formula (IIIb),

P²—X_(3 (IIIb))

wherein P² is as above defined, X₃ is the radical of formula

(a8″) —C(O)—CH(R^(1a)—H)—NH₂

(b8″) —C(O)—CH₂—CH(R^(2a)—H)—NH₂ wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6), with a compound of formula (IVa)

W₁—(O)C-y-Q  (IVa)

wherein W₁ and Q are as above defined, wherein y is the radical Y or Y′, wherein Y and Y′ are as above defined, and 1c-ii) when Q is Z₂, by converting the compounds obtained in the step 1c-i) into nitro derivative by reaction with a nitrate source as above described and 1c-iii) optionally deprotecting the compounds obtained in step 1c-i) or 1c-ii) as above described.

The reaction of a compound of formula (IIIb) wherein P² and X₃ are as above defined, with a compound of formula (IVa) wherein W₁ is OH, y and Q are as above defined, may be carried out as described in 1a-i) using a ratio (IIIb)/(IVa) 1:2.

The reaction of a compound of formula (IIIb) wherein P² and X₃ are as above defined, with a compound of formula (IVa) wherein W₁ is OR_(a), y and Q are as above defined, may be carried out as described in 1-i-2) using a ratio (IIIb)/(IVa) 1:2.

The compounds of formula (IIIb) are commercially available or can be obtained as known in the literature.

The compounds of formula (Ia) wherein W is —Cl or O—R_(a), X₁ is the radical selected from (a8′) or (b8′) wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6) and wherein Y, Y′ and Q are as above defined and T′ and T″ are C(O), can be obtained from the corresponding acids (Ia) wherein W is —OH as known in the literature.

1d) The compounds of formula (Ia) wherein W is —OH, X₁ is the radical selected from (a8′) or (b8′), wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6), Q, Y and Y′ are as above defined, T′ is C(O) or C(O)—X″ wherein X″ is as above defined, T″ is C(O), can be obtained 1d-i) by reacting a compound of formula (Ib)

P²—X_(3′)  (Ib)

wherein P² is as above defined, X_(3′) is the radical of formula

(a8″′) —C(O)—CH(R^(1a)—H)—NH-(T′-Y-Q)

(b8″′) —C(O)—CH₂—CH(R^(2a)—H)—NH-(T′-Y-Q)

wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6), with a compound of formula (IVa)

W₁—(O)C-y-Q (IVa)

wherein W₁ and Q are as above defined, wherein y is the radical Y′, wherein Y′ is as above defined, and 1d-ii) when Q is Z₂, by converting the compounds obtained in the step 1d-i) into nitro derivative by reaction with a nitrate source as above described and 1d-iii) optionally deprotecting the compounds obtained in step 1d-i) or 1d-ii) as above described.

The reaction of a compound of formula (Ib) wherein P² and X_(3′) are as above defined, with a compound of formula (IVa) wherein W₁ is OH, y and Q are as above defined, may be carried out as described in 1a-i).

The reaction of a compound of formula (Ib) wherein P² and X_(3′) are as above defined, with a compound of formula (IVa) wherein W₁ is OR_(a), y and Q are as above defined may be carried out as described in 1-i-2).

The compounds of formula (Ib) wherein T′ is C(O), P² and X_(3′) are as above defined, are obtained as described in 1a).

The compounds of formula (Ib) wherein T′ is C(O)—X″, P² and X_(3′) are as above defined, are obtained as described in 1b).

The compounds of formula (Ia) wherein W is —Cl or O—R_(a), X₁ is the radical selected from (a8′) or (b8′) wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6) and wherein Q, Y and Y′ are as above defined, T′ is C(O) or C(O)—X″ wherein X″ is as above defined, T″ is C(O), can be obtained from the corresponding acids (Ia) wherein W is —OH as known in literature.

1e) The compounds of formula (Ia) wherein W is —OH, X₁ is the radical selected from (a8′) or (b8′), wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6), Q is as above defined, Y and Y′ are the same and are as above defined, T′ and T″ are C(O)—X″— wherein X″ is as above defined, can be obtained 1e-i) by reacting a compound of formula (IIIb)

P²—X₃  (IIIb)

wherein P² and X₃ are as above defined, with a compound of formula (IVd)

R_(a)—O—C(O)—X″-y-Q  (IVd)

wherein R_(a) and Q are as above defined, wherein y is the radical Y′, wherein Y′ is as above defined, and 1e-ii) when Q is Z₂, by converting the compounds obtained in the step 1e-i) into nitro derivative by reaction with a nitrate source as above described and 1e-iii) optionally deprotecting the compounds obtained in step 1e-i) or 1e-ii) as above described.

The reaction of a compound of formula (IIIb) wherein P² and X₃ are as above defined, with a compound of formula (IVd) wherein R_(a), y and Q are as above defined, may be carried out as described in 1-i-2) using a ratio (IIIb)/(IVd) 1:2.

The compounds of formula (Ia) wherein W is —Cl or O—R_(a), X₁ is the radical selected from (a8′) or (b8′) wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6) and wherein Y and Y′, Q is as above defined and T′ and T″ are C(O)—X″— wherein X″ is as above defined, can be obtained from the corresponding acids (Ia) wherein W is —OH as known in literature.

1f) The compounds of formula (Ia) wherein W is —OH, X₁ is selected from (a8′) or (b8′), wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6), Q, Y and Y′ are as above defined, T′ is C(O) or C(O)—X″ wherein X″ is as above defined, T″ is C(O)—X″, can be obtained 1f-i) by reacting a compound of formula (Ib)

P²—X_(3′)  (Ib)

wherein X_(3′) and P² are as above defined, with a compound of formula (IVd)

W₁—O—C(O)—X″-y-Q  (IVd)

wherein W₁ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 1f-ii) when Q is Z₂, by converting the compounds obtained in the step 1f-i) into nitro derivative by reaction with a nitrate source as above described and 1f-iii) optionally deprotecting the compounds obtained in step 1f-i) or 1f-ii) as above described.

The reaction of a compound of formula (Ib) wherein P² and X_(3′) are as above defined, with a compound of formula (IVd) wherein W₁ is OH, y and Q are as above defined, may be carried out as described in 1a-i).

The reaction of a compound of formula (Ib) wherein P² and X_(3′) are as above defined, with a compound of formula (IVd) wherein W₁ is OR_(a), y and Q are as above defined may be carried out as described in 1-i-2).

The compounds of formula (Ib) wherein T′ is C(O), P² and X_(3′) are as above defined, are obtained as described in 1a).

The compounds of formula (Ib) wherein T′ is C(O)—X″, P² and X_(3′) are as above defined, are obtained as described in 1b).

The compounds of formula (Ia) wherein W is —Cl or O—R_(a), X₁ is a radical selected from (a8′) or (b8′) wherein R^(1a) is A5) or A6), R^(2a) is B5) or B6) and wherein Q, Y and Y′ are as above defined, T′ is C(O) or C(O)—X″ and T″ is C(O)—X, wherein X″ is as above defined, can be obtained from the corresponding acids (Ia) wherein W is —OH as known in literature.

1g) The compounds of formula (Ia) wherein W is —OH, X₁ is a radical is selected from (a8′) or (b8′), wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6), Q, Y and Y′ are as above defined, T′ is C(O) or C(O)—X″ wherein X″ is as above defined, T″ is C(O)—NR′ wherein R′ is above defined, can be obtained 1g-i) by reacting a compound of formula (Ib)

P²—X_(3′)  (1b)

wherein P² and X_(3′) are as above defined, with a compound of formula

R_(a)—O—(O)C—NR′-y-Q  (IVf)

wherein R_(a), R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 1g-ii) when Q is Z₂, by converting the compounds obtained in the step 1g-i) into nitro derivative by reaction with a nitrate source as above described and 1g-iii) optionally deprotecting the compounds obtained in step 1g-i) or 1g-ii) as above described.

The reaction of a compound of formula (Ib) wherein P² and X_(3′) are as above defined, with a compound of formula (IVf) wherein R_(a), R′, y, Q are as above defined, may be carried out as described in 1-i-2).

The compounds of formula (Ib) wherein T′ is C(O), wherein P² and X_(3′) are as above defined, are obtained as described in 1a-i), 1a-ii).

The compounds of formula (Ib) wherein T′ is C(O)—X″, wherein P² and X_(3′) are as above defined, are obtained as described in 1b-i), 1b-ii).

The compounds of formula (IVf) wherein R′, y and Q are as above defined, can be obtained from the compounds of formula HR′N-y-Q (IVg) by reaction with a chloroformate as known in the literature.

The compounds of formula (IVg) wherein y is as above defined and Q is Z₂ are commercially available, the compounds of formula (IVg) wherein y is as above defined and Q is —ONO₂ may be obtained from the compounds of formula P³—R′N-y-ONO₂ (IVh) wherein P³ is as above defined by deprotection of amino group as known in literature. The compounds of formula (IVh) wherein P³ and y are as above defined may be obtained from the alcohol P³—R′N-y-OH (IVi) by reacting with tetraalkylammonium nitrate as already described for analogous compounds. The compounds of formula (IVi) are commercially available or known in literature. Alternatively the compounds of formula (IVh) wherein P³ and y are as above defined may be obtained from the corresponding compounds of formula P³—R′N-y-Z₂ (IVl) wherein P³, y and Z₂ are as above defined, by reaction with a nitrate source as above described.

The compounds of formula (Ia) wherein W is —Cl or O—R_(a), X₁ is a radical selected from (a8′) or (b8′) wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6) and wherein Y Y′ and Q are as above defined and T′ is C(O) or C(O)—X″, T″ is C(O)—NR′—, wherein X″ and R′ are as above defined, can be obtained from the corresponding acids (Ia) wherein W is —OH as known in literature.

1h) The compounds of formula (Ia) wherein W is —OH, X₁ is a radical selected from (a8′) or (b8′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7), Q, Y and Y′ are as above defined, T′ is C(O) or C(O)—X″, T″ is X″ wherein X″ is above defined, can be obtained 1h-i) by reacting a compound of formula (Ie),

P²—X₅  (Ie)

wherein P² is defined above, X₅ is the radical of formula

(a8″′) —C(O)—CH(R^(1a)—OH)—NH-(T′-Y-Q)

(b8″′) —C(O)—CH₂—CH(R^(2a)—OH)—NH-(T′-Y-Q)

wherein R^(1a) is selected from A7), R^(2a) is selected from B7), with a compound of formula (IVe)

HX″-y-Q  (IVe)

wherein X″ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 1h-ii) when Q is Z₂, by converting the compounds obtained in the step 1h-i) into nitro derivative by reaction with a nitrate source as above described and 1h-iii) optionally deprotecting the compounds obtained in step 1h-i) or 1h-ii) as above described.

The reaction of a compound of formula (Ie) wherein P² and X₅ are as above defined, with a compound of formula (IVe) wherein y, X″ and Q are as above defined, may be carried out as described in 1-i-1).

The compounds of formula (Ie) wherein T′ is C(O), wherein P² and X₅ are as above defined, are obtained as described in 1a-i), 1a-ii).

The compounds of formula (Ie) wherein T′ is C(O)—X″, wherein P² and X₅ are as above defined, are obtained as described in 1b-i), 1b-ii).

The compounds of formula (Ia) wherein W is —Cl or O—R_(a), X₁ is a radical selected from (a8′) or (b8′) wherein R^(1a) is selected from A7), R^(2a) is selected from B7) and wherein Y, Y′ and Q are as above defined, T′ is C(O) or C(O)—X″, and T″ is X″ wherein X″ is as above defined, can be obtained from the corresponding acids (Ia) wherein W is —OH as known in literature.

1i) The compounds of formula (Ia) wherein W is —OH, X₁ is a radical selected from (a8′) or (b8′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7), Q, Y and Y′ are as above defined, T′ is C(O) or C(O)—X″ wherein X″ is as above defined, T″ is —NR′ wherein R′ is above defined, can be obtained 1i-i) by reacting a compound of formula (Ie),

P²—X₅  (Ie)

wherein is P² and X₅ are defined above, with a compound of formula (IVg)

HR′N-y-Q  (IVg)

wherein R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 1i-ii) when Q is Z₂, by converting the compounds obtained in the step 1i-i) into nitro derivative by reaction with a nitrate source such above described and 1i-iii) optionally deprotecting the compounds obtained in step 1i-i) or 1i-ii) as above described.

The reaction of a compound of formula (Ie) wherein P² and X₅ are as above defined, with a compound of formula (IVg) wherein R′, y and Q are as above defined, may be carried out as described in 1a-i).

The compounds of formula (Ia) wherein W is —Cl or O—R_(a), X₁ is the radical selected from (a8′) or (b8′) wherein R^(1a) is selected from A7), R^(2a) is selected from B7) and wherein Y, Y′ and Q are as above defined, T′ is C(O) or C(O)—X″ wherein X″ is as above defined, and T″ is —NR′ wherein R′ is as above defined can be obtained from the corresponding acids (Ia) wherein W is —OH as known in literature

1l) The compounds of formula (Ia) wherein W is —OH, X₁ is a radical selected from (a8′) or (b8′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7), Q, Y and Y′ are as above defined, T′ is C(O) or C(O)—X″ wherein X″ is as above defined, T″ is —O—CH(R)—O—C(O)—, wherein R′ is as above defined, can be obtained 1l-i) by reacting a compound of formula (Ie),

P²—X₅  (Ie)

wherein is P² and X₅ are defined above, with a compound of formula (IVm)

Hal-CH(R′)—O—(O)C-y-Q  (IVm)

wherein R′ and Q are as above defined, Hal is an halogen atom, y is the radical Y′, wherein Y′ is as above defined, and 1l-ii) when Q is Z₂, by converting the compounds obtained in the step 1l-i) into nitro derivative by reaction with a nitrate source such above described and 1l-iii) optionally deprotecting the compounds obtained in step 1l-i) or 1l-ii) as above described.

The reaction of a compound of formula (Ie) wherein P⁵ and X₅ are as above defined, with a compound of formula (IVm) wherein y, Q, R′ are as above defined may be carried out in the presence of a inorganic or organic base in an aprotic polar/non-polar solvent such as DMF, THF or CH₂Cl₂ at temperature in the range between 0° and 100° C. or in a double phase system H₂O/Et₂O temperature in the range between 20° and 40° C.

The compounds of formula (IVm) wherein y, Q, R′ are as above defined, Hal is an halogen atom may be obtained by reacting a compound R′—CH₂—CHO, commercially available, with a compound of formula Hal-(O)C-y-Q (IVn), wherein y and Q are as above defined, Hal is a chlorine atom and ZnCl₂ as known in literature.

The compounds of formula (IVn) may be obtained as known in literature.

The compounds of formula (Ia) wherein W is —Cl or O—R_(a), X₁ is a radical selected from (a8′) or (b8′) wherein R^(1a) is selected from A7), R^(2a) is selected from B7) and wherein Y, Y′, and Q are as above defined, T′ is C(O) or C(O)—X″ wherein X″ is as above defined, and T″ is —O—CH(R′)—O—C(O)— wherein R′ is as above defined can be obtained from the corresponding acids (Ia) wherein W is —OH as known in literature.

1m) The compounds of formula (Ia) wherein W is —OH, X₁ is a radical selected from (a8′) or (b8′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7), Q, Y and Y′ are as above defined, T′ is C(O) or C(O)—X″ wherein X″ is as above defined, T″ is —O—CH(R′)—O—C(O)O—, wherein R′ is as above defined, can be obtained 1m-i) by reacting a compound of formula (Ie),

P²—X₅  (Ie)

wherein is P² and X₅ are defined above, with a compound of formula (IVo)

Hal-CH(R′)—O—(O)C—O-y-Q  (IVo)

wherein R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, Hal is an halogen atom, and 1m-ii) when Q is Z₂, by converting the compounds obtained in the step 1m-i) into nitro derivative by reaction with a nitrate source such above described and 1m-iii) optionally deprotecting the compounds obtained in step 1m-i) or 1m-ii) as above described.

The reaction of a compound of formula (Ie) wherein P² and X₅ are as above defined, with a compound of formula (IVo) wherein y, R′, Q, Hal are as above defined may be carried out as described in 1m-i).

The compounds of formula (IVo) wherein y, R′, Q are as above defined, may be obtained by reacting the compounds of formula Hal-(R′)CH—OC(O)Hal, wherein Hal is as above defined, commercially available, with a compound of formula HO-y-Q (IVe) wherein y, Q are as above defined, in the presence of a inorganic or organic base in an aprotic polar or in an aprotic non-polar solvent such as DMF, THF or CH₂Cl₂ at temperatures range between 0° to 65° C.

The compounds of formula (Ia) wherein W is —Cl or O—R_(a), X₁ is a radical selected from (a8′) or (b8′) wherein R^(1a) selected from A7), R^(2a) selected from B7) and wherein Y, Y′ and Q are as above defined, T′ is C(O) or C(O)—X″ wherein X″ is as above defined, and T″ is —O—CH(R′)—O—C(O)O—, may be obtained from the corresponding acids (Ia) wherein W is —OH as known in literature.

1n) The compounds of formula (Ia) wherein W is —OH, X₁ is a radical selected from (a4′) or (b4′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7), Y′, Q and R⁴, are as above defined and T″ is X″ wherein X″ is as above defined, can be obtained 1n-i) by reacting a compound of formula (IIIc)

P²—X_(5′)  (IIIc)

wherein P² is defined above, X_(5′) is

(a4″) —C(O)—CH(R_(1a)—OH)—NH^(4a′)

(b4″) —C(O)—CH₂—CH(R_(2a)—OH)—NHR^(4a′)

wherein R_(a) is selected from A7), R^(2a) is selected from B7), with a compound of formula (IVe)

HX″-y-Q (IVe)

wherein X″ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 1n-ii) when Q is Z₂, by converting the compounds obtained in the step 1n-i) into nitro derivative by reaction with a nitrate source as above described and 1n-iii) optionally deprotecting the compounds obtained in step 1n-i) or 1-ii) as above described.

The reaction of a compound of formula (IIIc) wherein X_(5′) and P² are as above defined, with a compound of formula (IVe) wherein X″, y, Q are as above defined may be carried out as described in 1-i-1).

The compounds of formula (IIIc) wherein X_(5′) and P² are as above defined, are commercially available or can be obtained as known in the literature.

The compounds of formula (Ia) wherein W is —Cl or O—R_(a), X₁ is a radical selected from (a4′) or (b4′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7), Y′ and Q are as above defined, T″ is X″, wherein X″ is as above defined, can be obtained from the corresponding acids (Ia) wherein W is —OH as known in literature.

1o) The compounds of formula (Ia) wherein W is —OH, X₁ is a radical selected from (a4′) or (b4′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7), Y′, Q and R^(4a) are as above defined and T″ is —NR′ wherein R′ is as above defined, can be obtained 1o-i) by reacting a compound of formula (IIIc)

P²—X_(5′)  (IIIc)

wherein P² and X_(5′) are as above defined, with a compound of formula (IVg)

HR′N-y-Q  (IVg)

wherein R′ and Q are as above defined, y is the radical Y′, and 1o-ii) when Q is Z₂, by converting the compounds obtained in the step 1o-i) into nitro derivative by reaction with a nitrate source as above described and 1o-iii) optionally deprotecting the compounds obtained in step 1o-i) or 1o-ii) as above described.

The reaction of a compound of formula (IIIc) wherein X_(5′) and P² are as above defined, with a compound of formula (IVg) wherein R′, y and Q are as above defined may be carried out as described in 1a-i).

The compounds of formula (Ia) wherein W is —Cl or —OR_(a), X₁ is a radical selected from (a4′) or (b4′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7) and wherein Y′ and Q are as above defined and T″ is —NR′ wherein R′ is as above defined, can be obtained from the corresponding acids (Ia) wherein W=—OH as known in literature.

1p) The compounds of formula (Ia) wherein W is —OH, X₁ is a radical selected from (a4′) or (b4′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7), Y′, Q and R^(4a′) are as above defined and T″ is —O—CH(R′)—O—C(O), wherein R′ is as above defined, can be obtained 1p-i) by reacting a compound of formula (IIIc)

P²—X₅  (IIIc)

wherein P² and X_(5′) are as above defined, with a compound of formula (IVm)

Hal-CH(R′)—O—(O)C-y-Q  (IVm)

wherein R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, Hal is an halogen atom and 1p-ii) when Q is Z₂, by converting the compounds obtained in the step 1p-i) into nitro derivative by reaction with a nitrate is source as above described and 1p-iii) optionally deprotecting the compounds obtained in step 1p-i) or 1p-ii) as above described.

The reaction of a compound of formula (IIIc) wherein P² and X_(5′) are as above defined, with a compound of formula (IVm) wherein R′, y, Q, Hal are as above defined, may be carried out as described in 1l-1).

The compounds of formula (Ia) wherein W is —Cl or OR_(a), X₁ is a radical selected from (a4′) or (b4′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7) and wherein Y and Q are as above defined and T″ is the group —O—CH(R′)—O—C(O), wherein R′ is as above defined, can be obtained from the corresponding acids (Ia) wherein W=—OH as known in literature.

1q) The compounds of formula (Ia) wherein W is —OH, X, is a radical selected from (a4′) or (b4′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7), Y′, Q and R^(4a′) are as above defined and T″ is —O—CH(R′)—O—C(O)—O—, wherein R′ is as above defined, can be obtained 1q-i) by reacting a compound of formula (IIIc)

P²—X₅  (IIIc)

wherein P² and X_(5′) are as above defined, with a compound of formula (IVo)

Hal-CH(R′)—O—(O)C—O-y-Q  (IVo)

wherein R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, Hal is an halogen atom and 1q-ii) when Q is Z₂, by converting the compounds obtained in the step 1q-i) into nitro derivative by reaction with a nitrate source as above described and 1q-iii) optionally deprotecting the compounds obtained in step 1q-i) or 1q-ii) as above described.

The reaction of a compound of formula (IIIc) wherein P² and X_(5′) are as above defined, with a compound of formula (IVo) wherein R′, y, Q, Hal are as above defined, may be carried out as described in 1l-1).

The compounds of formula (Ia) wherein W is —Cl or OR_(a), X₁ is a radical selected from (a4′) or (b4′), wherein R^(1a) is selected from A7), R^(2a) is selected from B7) and wherein Y and Q, are as above defined and T″ is the group —O—CH(R′)—O—C(O)—O—, wherein R′ is as above defined, can be obtained from the corresponding acids (Ia) wherein W=—OH as known in literature.

2) The compounds of general formula (I) as above defined wherein a is equal to 1, the radical R_(X) is selected from (a2), (a4), (a8), (b2), (b4), (b8), (c2), (e2), (f1), (g2), (h1), (i1), (l2), (m2), (n2), (o2), (p2), (q2), (r2), (s2), (t2), (u2), (v2), Z is —CH(R′)—O— wherein R′ is selected from H or straight or branched C₁-C₄ alkyl, can be obtained: 2-i) by reacting a compound of formula (II₁) as above defined with a compound of formula (If)

Hal-CH(R′)—O—X₁  (If)

wherein Hal is an halogen atom, R′ and X₁ are as above defined and 2-ii) when Q is Z₂, by converting the compounds obtained in the step 2-i) into nitro derivative by reaction with a nitrate source as above described and 2-iii) optionally deprotecting the compounds obtained in step 2-i) or 2-ii) as above described.

The reaction of a compound of formula (If) wherein X₁ and R′ are as above defined, with a compound of formula (II₁) may be carried out as described in 1l-i).

The compounds of formula (If) are obtained by reacting a compound R′—CHO, wherein R′ is as above defined with compounds of formula (Ia)

W—X₁  (Ia)

wherein W is a chlorine atom, X₁ is as above defined, and ZnCl₂ as known in literature. 3) The compounds of general formula (I) as above defined wherein a is equal to 1, the radical R_(X) is selected from (a1), (a3), (a7), (b1), (b3), (b7), (c1), (e1), (f2), (g1), (h2), (i2), (l1), (m1), (n1), (o1), (p1), (q1), (r1), (s1), (t1), (u1), (v1), Z is C(O), can be obtained 3-i) by reacting a compound of formula (II₃)

R—C(O)—O—R_(a)  (II₃)

wherein R and R_(a) are as above defined, with a compound of formula (Ig)

H—X₂  (Ig)

wherein X₂ is a radical having the following meanings:

(a1′) —HN—CH(R^(1′))—C(O)-(T-Y-Q)

(a3′) —HN—CH(R^(1a)-T″-Y′-Q)-COOR^(3a′)

(a7′) —HN—CH(R^(1a)-T″-Y∝-Q)-C(O)-(T-Y-Q)

(b1′) —HN—CH(R^(2′))—CH₂C(O)-(T-Y-Q)

(b3′) —HN—CH(R^(2a)-T″-Y′-Q)-CH₂COR^(3a′)

(b7′) —HN—CH(R^(2a)-T″-Y′-Q)-CH₂—C(O)-(T-Y-Q)

wherein R^(1′), R_(1a), R^(2′), R^(2a) are as above defined R^(3a′) is selected from P², —OR^(5a) or

wherein R_(5a) is as above defined;

(c1′) —HN—(CH₂)_(b)—C(O)-(T-Y-Q);

wherein T, T″, Y and Y′ are as above defined, 3-ii) when Q is Z₂, by converting the compounds obtained in the step 3-i) into nitro derivative by reaction with a nitrate source such above described and 3-iii) optionally deprotecting the compounds obtained in step 3-i) or 3-ii) as above described.

The reaction of a compound of formula (II3), wherein R and R_(a) are as above defined, with a compound of formula (Ig) wherein X₁ is as above defined, may be carried out as described in 1-i-2).

The compounds of formula (II₃) wherein R and R_(a) are as above defined, are obtained from the compounds of formula (II₁) by reaction with the compounds of formula Cl—C(O)—O—R_(a) wherein R_(a) is as above defined, as known in literature.

3a) The compounds of formula (Ig) wherein X₂ is selected from (a1′), (a3′), (b1′), (b3′), (c1′), (e1′), (f2′), (g1′), (h2′), (t1′), (u1′), (v1′), wherein R^(1′) is selected from A1), A2′), A3′) or A4′), R^(1a) is selected from A7), R^(2a) is selected from B7) and R^(2′) is selected from B1), B2′), B3′) or B4′), Y and Y′ are as above defined, T and T″ are X″ wherein X″ is as above defined may be obtained 3a-i) by reacting a compound of formula (IIIe),

P³—X₆  (IIIe)

wherein P³ is as above defined, X₆ is a radical having the following meanings:

(a1″) —HN—CH(R^(1′))—C(O)—OH

(a3″) —HN—CH(R^(1a)—OH)—COOR^(3a′)

(b1″) —HN—CH(R^(2′))₂—CH₂C(O)—OH

(b3″) —HN—CH(R^(2a)—OH)—CH₂COOR^(3a′)

wherein R^(1′) is selected from A1), A2′), A3′) or A4′), R^(1a) is selected from A7), R^(2a) is selected from B7) and R^(2′) is selected from B1), B2′), B3′) or B4′), and R^(3a′) is defined above

(c1″) —HN—(CH₂)_(b)—C(O)—OH;

with a compound of formula (IVe)

HX″-y-Q  (IVe)

wherein Q and X″ are as above defined y is the radical Y when X₆ is selected from (a1′), (b1′), (c1′), (e1′), (r2′), (g1′), (h2′), (i2′), (l1′), (m1′), (n1′), (o1′), (p1′), (q1′), (r1′), (s1′), (t1′), (u1′) and (v1′), y is the radical Y′ when X₆ is selected from (a3′) and (b3′), wherein Y and Y′ are as defined above, and 3a-ii) when Q is Z₂, by converting the compounds obtained in the step 3a-i) into nitro derivative by reaction with a nitrate source as above described and 3a-iii) optionally deprotecting the compounds obtained in step 3a-i) or 3a-ii) as above described.

The reaction of a compound of formula (IIIe) wherein P³ and X₆ are as above defined, with a compound of formula (IVe), wherein y, Q and X″ are as above defined, may be carried out as described in 1-i-1).

The compounds of formula (IIIe) are commercially available or can be obtained as known in the literature.

3b) The compounds of formula (Ig) wherein X₂ is selected from (a1′), (a3′), (b1′), (b3′), (c1′), (e1′), (r2′), (g1′), (h2′), (t1′), (u1′), (v1′), wherein R^(1′) is selected from A1), A2′), A3′) or A4′), R^(1a) is selected from A7), R^(2a) is selected from B7) and R^(2′) is selected from B1), B2′), B3′) or B4′), and R^(3a′), Y and Y′ are as above defined, T and T″ are —NR′ wherein R′ is as above defined may be obtained 3b-i) by reacting a compound of formula (IIIe),

P³—X₆  (IIIe)

wherein P³ and X₆ are as above defined, with a compound of formula

HR′N-y-Q  (IVg)

wherein R′ and Q are as above defined, y is the radical Y when X₆ is selected from (a1′), (b1′), (c1′), (e1′), (r2′), (g1′), (h2′), (i2′), (l1′), (m1′), (n1′), (o1′), (p1′), (q1′), (r1′), (s1′), (t1′), (u1′) and (v1′), y is the radical Y′ when X₆ is selected from (a3′) and (b3′), wherein Y and Y′ are as defined above, and 3b-ii) when Q is Z₂, by converting the compounds obtained in the step 3b-i) into nitro derivative by reaction with a nitrate source as above described and 3b-iii) optionally deprotecting the compounds obtained in step 3b-i) or 3b-ii) as above described.

The reaction of a compound of formula (IIIe) wherein P³ and X₆ are as above defined, with a compound of formula (IVg) wherein R′, y, Q are as above defined, may be carried out 1a-i).

3c) The compounds of formula (Ig) wherein X₂ is selected from (a1′), (a3′), (b1′), (b3′), (c1′), (e1′), (r2′), (g1′), (h2′), (t1′), (u1′), (v1′), wherein R^(1′) is selected from A1), A2′), A3′), A4′), R^(1a) is selected from A7), R^(2a) is selected from B7) and R^(2′) is selected from B1), B2′), B3′), B4′), and R^(3a′), Y and Y′ are as above defined, T and T″ are —O—CH(R′)—O—C(O)—, wherein R′ is as above defined, may be obtained 3c-i) by reacting a compound of formula (IIIe)

P³—X₆  (IIIe)

wherein P³, X₆ are as above defined with compounds of formula (IVm)

Hal-CH(R′)—O—(O)C-y-Q  (IVm)

wherein R′ and Q are as above defined, Hal is an halogen atom, y is the radical Y when X₆ is selected from (a1′), (b1′), (c1′), (e1′), (f2′), (g1′), (h2′), (i2′), (l1′), (m1′), (n1′), (o1′), (p1′), (q1′), (r1′), (s1′), (t1′), (u1′) and (v1′), y is the radical Y′ when X₆ is selected from (a3′) and (b3′), wherein Y and Y′ are as defined above, and 3c-ii) when Q is Z₂, by converting the compounds obtained in the step 3c-i) into nitro derivative by reaction with a nitrate source as above described and 3c-iii) optionally deprotecting the compounds obtained in step 3c-i) or 3c-ii) as above described.

The reaction of a compound of formula (IIIe) wherein P³ and X₆ are as above defined, with a compound of formula (IVm) wherein y, Q, R′ are as above defined, may be carried out as described in 1l-i)

3d) The compounds of formula (Ig) wherein X₂ is selected from (a1′), (a3′), (b1′), (b3′), (c1′), (e1′), (r2′), (g1′), (h2′), (i2′), (l1′), (m1′), (n1′), (o1′), (p1′), (q1′), (r1′), (s1′), (t1′), (u1′), (v1′), wherein R1′ is selected from A1), A2′), A3′) or A4′), R^(1a) is selected from A7), R^(2a) is selected from B7) and R^(2′) is selected from B1), B2′), B3′) or B4′), and R^(3a′), Y and Y′ are as above defined, T and T″ are —O—CH(R′)—O—C(O)O— wherein R′ is as above defined may be obtained 3d-i) by reacting a compound of formula (IIIe)

P³—X₆  (IIIe)

wherein P³ and X₆ are as above defined, with compounds of formula (IVo)

Hal-CH(R′)—O—(O)C—O-y-Q  (IVo)

wherein R′ and Q are as above defined, Hal is an halogen atom y is the radical Y when X₆ is selected from (a1′), (b1′), (c1′), (e1′), (f2′), (g1′), (h2′), (i2′), (l1′), (m1′), (n1′), (o1′), (p1′), (q1′), (r1′), (s1′), (t1′), (u1′) and (v1′), y is the radical Y′ when X₆ is selected from (a3′) and (b3′), wherein Y and Y′ are as defined above, and 3d-ii) when Q is Z₂, by converting the compounds obtained in the step 3d-i) into nitro derivative by reaction with a nitrate source as above described and 3d-iii) optionally deprotecting the compounds obtained in step 3d-i) or 3d-ii) as above described.

The reaction of a compound of formula (IIIe) wherein P³ and X₆ are as above defined, with a compound of formula (IVo) wherein y, Q, R′ are as above defined, may be carried out as described in 1l-i).

3e) The compounds of formula (Ig) wherein X₂ is selected from (a7′) or (b7′) wherein R^(1a) is selected from A5) or A6), R^(b) is selected from B5) or B6) T″ is —C(O)—, T is —X″, —NR′, —O—CH(R′)—O—C(O)— or —O—CH(R′)—O—C(O)O— wherein X″ and R′, Y and Y′ are as above defined, may be obtained 3e-i) by reacting a compound of formula (Ih)

P³—X₇  (Ih)

wherein P³ is as above defined and X₇ is the radical having the following meaning

(a7″) —HN—CH(R^(1a)—H)—C(O)-(T-Y-Q)

(b7″) —HN—CH(R^(2a)—H)—CH₂—C(O)-(T-Y-Q)

wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6), with compounds of formula (IVa)

W₁—C(O)-y-Q  (IVa)

wherein W₁ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 3e-ii) when Q is Z₂, by converting the compounds obtained in the step 3e-i) into nitro derivative by reaction with a nitrate source as above described and 3e-iii) optionally deprotecting the compounds obtained in step 3e-i) or 3e-ii) as above described.

The reaction of a compound of formula (Ih) wherein P³ and X₇ are as above defined, with a compound of formula (IVa) wherein y, Q, W₁ are as above defined may be carried out as described in 1-i-1), 1-i-2), 1-i-3) and 1a-i).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —X″ are obtained as described in 3a).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —NR′ are obtained as described in 3b).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —O—CH(R′)—O—C(O)— are obtained as described in 3c).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —O—CH(R′)—O—C(O)O— are obtained as described in 3d).

3f) The compounds of formula (Ig) wherein X₂ is selected from (a7′) or (b7′) wherein R^(1a) is selected from A5) or A6), R^(1b) is selected from B5) or B6) T″ is —C(O)—X″, T is —X″, —NR′, —O—CH(R′)—O—C(O)— or —O—CH(R′)—O—C(O)O— wherein X″ and R, Y and Y′ are as above defined, may be obtained 3f-i) by reacting a compound of formula (Ih)

P³—X₇  (Ih)

wherein P³ and X₇ are as above defined with compounds of formula (IVd)

R_(a)—O—C(O)—X″-y-Q  (IVd)

wherein R_(a), X″ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 3f-ii) when Q is Z₂, by converting the compounds obtained in the step 3f-i) into nitro derivative by reaction with a nitrate source as above described and 3f-iii) optionally deprotecting the compounds obtained in step 3e-i) or 3f-ii) as above described. The reaction of a compound of formula (Ih) wherein P³ and X₇ are as above defined, with a compound of formula (IVd) wherein y, Q, R_(a) are as above defined, may be carried out as described in 1-i-2). 3g) The compounds of formula (Ig) wherein X₂ is selected from (a7′) or (b7′) wherein R^(1a) is selected from A5) or A6), R^(1b) is selected from B5) or B6), T″ is —C(O)—NR′, T is X″, NR′, —O—CH(R′)—O—C(O)— or —O—CH(R′)—O—C(O)O— wherein X″ and R′, Y and Y′ are as above defined, may be obtained 3g-i) by reacting a compound of formula (Ih)

P³—X₇  (Ih)

wherein P³ and X₇ are as above defined, with compounds of formula (IVf)

R_(a)—O—C(O)—NR′-y-Q  (IVf)

wherein R_(a) and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 3g-ii) when Q is Z₂, by converting the compounds obtained in the step 3g-i) into nitro derivative by reaction with a nitrate source as above described and 3g-iii) optionally deprotecting the compounds obtained in step 3g-i) or 3g-ii) as above described.

The reaction of a compound of formula (Ih) wherein P³ and X₇ are as above defined, with a compound of formula (IVf) wherein y, Q, R_(a) and R′ are as above defined may be carried out as described in 1-i-2).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —X″ are obtained as described in 3a).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —NR′ are obtained as described in 3b).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —O—CH(R′)—O—C(O)— are obtained as described in 3c).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —O—CH(R′)—O—C(O)O— are obtained as described in 3d).

3h) The compounds of formula (Ig) wherein X₂ is selected from (a7′) or (b7′) wherein R_(a) is selected from A7), R^(1b) is selected from B7), T″ is —X″, T is —X″, —NR′, —O—CH(R′)—O—C(O)— or —O—CH(R′)—O—C(O)O— wherein X″ and R′, Y and Y′ are as above defined, may be obtained 3h-i) by reacting a compound of formula (Ih)

P³—X₇  (Ih)

wherein P³ is as above defined and X₇ is as above defined wherein R^(1a) is selected from A7), R^(1b) is selected from B7), with compounds of formula (IVe)

H—X″-y-Q  (IVe)

wherein X″ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 3h-ii) when Q is Z₂, by converting the compounds obtained in the step 3h-i) into nitro derivative by reaction with a nitrate source as above described and 3h-iii) optionally deprotecting the compounds obtained in step 3h-i) or 3h-ii) as above described.

The reaction of a compound of formula (Ih) wherein P³ and X₇ are as above defined, with a compound of formula (IVe) wherein y, Q, X″ are as above defined, may be carried out as described in 1-i-1), 1-i-2) and 1a-1).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —X″ are obtained as described in 3a).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —NR′ are obtained as described in 3b).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —O—CH(R′)—O—C(O)— are obtained as described in 3c).

The compounds of formula (Ih) wherein P³ and X₇ are as above defined, T is —O—CH(R′)—O—C(O)O— are obtained as described in 3d).

3i) The compounds of formula (Ig) wherein X₂ is selected from (a7′) or (b7′) wherein R^(1a) is selected from A7), R^(1b) is selected from B7), T″ is NR′, T is —X″, —NR′, —O—CH(R′)—O—C(O)— or —O—CH(R′)—O—C(O)O— wherein X″ and R′, Y and Y′ are as above defined, may be obtained 3i-i) by reacting a compound of formula (Ih)

P³—X₇  (Ih)

wherein P³ and X₇ are as above defined, with compounds of formula (IVg)

H—NR′-y-Q  (IVg)

wherein R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 3i-ii) when Q is Z₂, by converting the compound obtained in the step 3i-i) into nitro derivative by reaction with a nitrate source as above described and 3i-iii) optionally deprotecting the compounds obtained in step 3i-i) or 3i-ii) as above described.

The reaction of a compound of formula (Ih) wherein P³ and X₈₇ are as above defined, with a compound of formula (IVg) wherein y, Q, R′ are as above defined, may be carried out as described in 1a-i).

3l) The compounds of formula (Ig) wherein X₂ is selected from (a7′) or (b7′) wherein R_(1a) is selected from A7), R^(1b) is selected from B7), T″ is —O—CH(R′)—O—C(O)—, T is X″, NR′, —O—CH(R′)—O—C(O)— or —O—CH(R′)—O—C(O)O— wherein X″ and R′, Y and Y′ are as above defined, may be obtained 3l-i) by reacting a compound of formula (Ih)

P³—X₇  (Ih)

wherein P³ and X₈ are as above defined with compounds of formula (IVm)

Hal-CH(R′)—O—(O)C-y-Q  (IVm)

wherein R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, Hal is an halogen atom and 3l-ii) when Q is Z₂, by converting the compounds obtained in the step 3l-i) into nitro derivative by reaction with a nitrate source as above described and 3l-iii) optionally deprotecting the compounds obtained in step 3l-i) or 3l-ii) as above described.

The reaction of a compound of formula (Ih) wherein P³ and X₇ are as above defined, with a compound of formula (IVm) wherein y, Q, R′ are as above defined, may be carried out as described in 1l-i).

3m) The compounds of formula (Ig) wherein X₂ is selected from (a7′) or (b7′) wherein R_(1a) is selected from A7), R^(1b) is selected from B7), T″ is —O—CH(R′)—O—C(O)O—, T is X″, NR′, —O—CH(R′)—O—C(O)— or —O—CH(R′)—O—C(O)O— wherein X″ and R′, Y and Y′ are as above defined, may be obtained 3m-i) by reacting a compound of formula (Ih)

P³—X_(7 (Ih))

wherein P¹ and X₈ are as above defined with a compound of formula (IVo)

Hal-CH(R′)—O—(O)C—O-y-Q (IVo)

wherein R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, Hal is an halogen atom and 3m-ii) when Q is Z₂, by converting the compounds obtained in the step 3m-i) into nitro derivative by reaction with a nitrate source as above described and 3m-iii) optionally deprotecting the compounds obtained in step 3l-i) or 3m-ii) as above described.

The reaction of a compound of formula (Ih) wherein P³ and X₇ are as above defined, with a compound of formula (IVo) wherein y, Q, R′ are as above defined, may be carried out as described in 1l-i).

3n) The compounds of formula (Ig) wherein X₂ is selected from (a3′) or (b3′), wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6), Y′ is as above defined, T″ is C(O) may be obtained 3n-i) by reacting a compound of formula (IIIf),

P³—X₉  (IIIf)

wherein P³ is as above defined, X₉ is a radical having the following meaning

(a3″) —HN—CH(R^(1a)—H)—COR^(3a′)

(b3″) —HN—CH(R^(2a)—H)—CH₂COOR^(3a′)

wherein R^(1a) is selected from A5 or A6) and R^(2a) is selected from B5) or B6), wherein R^(3a′) is as above defined, with a compound of formula (IVa)

W₁—C(O)-y-Q  (IVa)

wherein W₁ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 3n-ii) when Q is Z₂, by converting the compounds obtained in the step 3n-i) into nitro derivative by reaction with a nitrate source as above described and 3n-iii) optionally deprotecting the compounds obtained in step 3n-i) or 3n-ii) as above described.

The reaction of a compound of formula (IIIf) wherein P³ and X₉ are as above defined, with a compound of formula (IVa) wherein W₁, y, Q are as above defined, may be carried out as described in 1-i-1), 1-i-2), 1a-1).

The compounds of formula (IIIf) wherein P³ and X₉ are as above defined, are commercially available or obtained as known in literature.

3o) The compounds of formula (Ig) wherein X₂ is selected from (a3′) or (b3′), wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6), Y′ is as above defined, T″ is C(O)—X″ wherein X″ is as above defined, can be obtained 3o-i) by reacting a compound of formula (IIIf)

P³—X₉  (IIIf)

wherein P³ and X₉ are as above defined with a compound of formula (IVd)

R_(a)—O—C(O)—X″-y-Q  (IVd)

wherein R_(a), X″, Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 3o-ii) when Q is Z₂, by converting the compounds obtained in the step 3o-i) into nitro derivative by reaction with a nitrate source as above described and 3o-iii) optionally deprotecting the compounds obtained in step 3o-i) or 3o-ii) as above described.

The reaction of a compound of formula (IIIf) wherein P³ and X₉ are as above defined, with a compound of formula (IVd) wherein R_(a), X″, y, Q are as above defined, may be carried out as described in 1-i-2).

3p) The compounds of formula (Ig) wherein X₂ is selected from (a3′) or (b3′), wherein R^(1a) is selected from A5) or A6), R^(2a) is selected from B5) or B6), Y′ is as above defined, T″ is C(O)—NR′ wherein R′ is as above defined, can be obtained 3p-i) by reacting a compound of formula (IIIg),

P³—X₉  (IIIf)

wherein P³ and X₉ are as above defined, with a compound of formula (IVf)

R_(a)—O—(O)C—NR′-y-Q  (IVf)

wherein R_(a), R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 3p-ii) when Q is Z₂, by converting the compounds obtained in the step 3p-i) into nitro derivative by reaction with a nitrate source as above described and 3p-iii) optionally deprotecting the compounds obtained in step 3p-i) or 3p-ii) as above described.

The reaction of a compound of formula (IIIf) wherein P³ and X₉ are as above defined, with a compound of formula (IVf) wherein R_(a), R′, y, Q are as above defined, may be carried out as described in 1-i-2).

4) The compounds of general formula (I) as above defined wherein a is equal to 1, the radical R_(X) is selected from (d1), (d2), (d3), (d4), (d7) or (d8), Z is C(O), can be obtained 4-i) by reacting a compound of formula (II₃) as above defined wherein R_(a) is as above defined, with a compound of formula (Im)

H—X₁₂  (Im)

wherein X₁₂ is the radical R_(X) having the following meaning

(d1′) —HN—CH(R^(12′))—CH₂—O-(T″′-Y-Q)

(d2′) —O—CH₂—CH(R^(12′))—NH-(T′-Y-Q)

(d3′) —HN—CH(R^(12a)-T″-Y′-Q)-CH₂OH

(d4′) —O—CH₂—CH(R^(12a)-T″-Y′-Q)-NHR^(4a)

(d7′) —HN—CH(R^(12a)-T″-Y′-Q)-CH₂—O-(T″′-Y-Q)

(d8′) —O—CH₂—CH(R^(12a)-T″-Y′-Q)-NH-(T′-Y-Q)

wherein R^(12′) is

D1),

D2′) —CH₂—OP¹, —CH(CH₃)—OP¹, —CH₂—[(C₆H₄)-4-OP¹], —CH₂—[(C₆H₃)-(3,5-diiodo)-4-OP¹], —CH₂—[(C₆H₃)-3-nitro-4-OP¹]; D3′) —CH₂—NHR″″, —(CH₂)₂—NHR″″, —(CH₂)₃—NHR″″, —(CH₂)₄—NHR″″, wherein R″″ is as above defined; D4′) —CH₂—C(O)R″″, —(CH₂)₂—C(O)R″″′, —(CH₂)₄—C(O)R″″′, wherein R″″′ is as above defined; wherein R^(12a) is as above defined; and 4-ii) when Q is Z₂, by converting the compounds obtained in the step 4-i) into nitro derivative by reaction with a nitrate source as above described and 4-iii) optionally deprotecting the compounds obtained in step 4-i) or 4-ii) as above described.

The reaction of a compound of formula (II₃) wherein R and R_(a) are as above defined, with a compound of formula (Im) wherein X₁₂ is as above defined, may be carried out as described in 1-i-2).

4a) The compounds of formula (Im) wherein X₁₂ is selected from (d1′), (d2′), (d3′) or (d4′) wherein R^(12′) is selected from D1), D2′), D3′) or D4′) and R^(12a) is selected from D5) or D6), Y and Y′ are as above defined, T′ and T″ and T″′ are C(O) can be obtained 4a-i) by reacting a compound of formula (IIIi),

P⁴—X₁₃  (IIIi)

wherein P⁴ is P³ or P¹ as above defined and X₁₃ is a radical having the following meaning

(d1″) —HN—CH(R^(12′))—CH₂—OH

(d2″) —O—CH₂—CH(R^(12′))—NH₂

(d3″) —HN—CH(R^(2a)—H)—CH₂OP¹

(d4″) —O—CH₂—CH(R^(12a)—H)—NHR^(4a′)

wherein R^(12′) is D1), D2′), D3′) or D4′), R^(12a) is D5) or D6), R^(4a′) and P¹ are as above defined, with a compound of formula (IVa)

W₁—(O)C-y-Q  (IVa)

wherein Q and W₁ are as above defined, y is the radical Y when X₁₃ is selected from (d1′) or (d2′), y is the radical Y′ when X₁₃ is selected from (d3′) or (d4′), wherein Y and Y′ are as above defined, and 4a-ii) when Q is Z₂, by converting the compounds obtained in the step 4a-i) into nitro derivative by reaction with a nitrate source as above described and 4a-iii) optionally deprotecting the compounds obtained in step 4a-i) or 4a-ii) as above described.

The reaction of a compound of formula (IIIi) wherein X₁₃ and P⁴ are as above defined, with a compound of formula (IVa) wherein W₁, y and Q are as above defined, may be carried out as described in 1-i-1) and 1-i-2).

The compounds of formula (IIIi) wherein X₁₃ and P⁴ are as above described, are commercially available or known in literature.

4b) The compounds of formula (Im) wherein X₁₂ is selected from (d1′), (d2′), (d3′) or (d4′) wherein R^(12′) is selected from D1), D2′), D3′) or D4′) and R^(2a) is selected from D5) or D6), Y and Y′ are as above defined, T′ and T″ and T″′ are C(O)—X″, wherein X″ is as above defined, can be obtained 4b-i) by reacting a compound of formula (IIIi),

P⁴—X₁₃  (IIIi)

wherein P⁴ and X₁₃ are defined above, with a compound of formula (IVd)

R_(a)—O—(O)C—X″-y-Q  (IVd)

wherein Q, R_(a) and X″ are as above defined, y is the radical Y when X₁₃ is selected from (d1′) or (d2′), y is the radical Y′ when X₁₃ is selected from (d3′) or (d4′), wherein Y and Y′ are as above defined, and 4b-ii) when Q is Z₂, by converting the compounds obtained in the step 4b-i) into nitro derivative by reaction with a nitrate source as above described and 4b-iii) optionally deprotecting the compounds obtained in step 4b-i) or 4b-ii) as above described.

The reaction of a compound of formula (IIIi) wherein X₁₃ and P⁴ are as above defined, with a compound of formula (IVd) wherein y, Q, R_(a), and X″ are as above defined, may be carried out as described in 1-i-2).

4c) The compounds of formula (Im) wherein X₁₂ is selected from (d7′) or (d8′) wherein R^(12a) is selected from D5) or D6), Y′ and Y is are as above defined, T′ and T″ and T″′ are C(O), can be obtained 4c-i) by reacting a compound of formula (IIIl),

P⁴—X₁₄  (IIIl)

wherein P⁴ is P¹ or P³, X₁₄ is the radical having the following meaning

(d7″) —HN—CH(R^(2a)—H)—CH₂—OH

(d8″) —O—CH₂—CH(R^(12a)—H)—NH₂

wherein R^(12a) is selected from D5) or D6), with a compound of formula (IVa)

W₁—(O)C-y-Q  (IVa)

wherein W₁ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 4c-ii) when Q is Z₂, by converting the compounds obtained in the step 4c-i) into nitro derivative by reaction with a nitrate source as above described and 4c-iii) optionally deprotecting the compounds obtained in step 4c-i) or 4c-ii) as above described.

The reaction of a compound of formula (IIIl) wherein P⁴ and X₁₄ are as above defined, with a compound of formula (IVa) wherein W₁ is OH, y and Q are as above defined, may be carried out as described in 1-i-1) using a ratio (IIIl)/(IVa) 1:2.

The reaction of a compound of formula (IIIl) wherein P⁴ and X₁₄ are as above defined, with a compound of formula (IVa) wherein W₁ is OR_(a), y and Q are as above defined, may be carried out as described in 1-i-2) using a ratio (IIIl)/(IVa) 1:2.

The compounds of formula (IIIl) wherein P⁴ and X₁₄ are as above described, are commercially available or known in literature.

4d) The compounds of formula (Im) wherein X₁₂ is selected from (d7′) or (d8′) wherein R^(12a) is selected from D5) or D6), Q, Y and Y′ are as above defined, T′, T″′ and T″ are C(O), can be obtained 4d-i) by reacting a compound of formula (In)

P⁴—X₁₅  (In)

wherein P⁴ is defined above and X₁₅ is the radical having the following meaning

(d7″′) —HN—CH(R^(2a)—H)—CH₂—O-(T″-Y-Q)

(d8″′) —O—CH₂—CH(R^(2a)—H)—NH-(T′-Y-Q)

wherein R^(12a) is selected from D5) or D6), Y, Q, T′ and T″′ are as above defined, with a compound of formula (IVa)

W₁—(O)C-y-Q  (IVa)

wherein W₁, y and Q′ are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 4d-ii) when Q is Z₂, by converting the compounds obtained in the step 4d-i) into nitro derivative by reaction with a nitrate source as above described and 4d-iii) optionally deprotecting the compounds obtained in step 4d-i) or 4d-ii) as above described.

The reaction of a compound of formula (In) wherein P⁴ and X₁₅ are as above defined, with a compound of formula (IVa) wherein W₁ is OH, y and Q are as above defined, may be carried out as described in 1-i-1).

The reaction of a compound of formula (In) wherein P⁴ and X₁₅ are as above defined, with a compound of formula (IVa) wherein W₁ is OR_(a), y and Q are as above defined, may be carried out as described in 1-i-2).

The compounds of formula (In) wherein P⁴ and X₁₅ are as above defined, T′ and T″′ are —C(O)— can by obtained as described in 4a).

4e) The compounds of formula (Im) wherein X₁₂ is selected from (d7′) or (d8′) wherein R^(12a) is selected from D5) or D6), Y and Y′ are the same and are as above defined, T′, T″ and T″′ are C(O)—X″ wherein X″ is as above defined, can be obtained 4e-i) by reacting a compound of formula (IIIl),

P⁴—X₁₄  (IIIl)

wherein P⁴ and X₁₄ are as above defined, with a compound of formula (IVd)

R_(a)—O—C(O)—X″-y-Q  (IVd)

wherein R_(a), X″ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 4e-ii) when Q is Z₂, by converting the compounds obtained in the step 4e-i) into nitro derivative by reaction with a nitrate source as above described and 4e-iii) optionally deprotecting the compounds obtained in step 4e-i) or 4e-ii) as above described.

The reaction of a compound of formula (IIIl) wherein P⁴ and X₁₄ are as above defined, with a compound of formula (IVd) wherein R_(a), X″, y and Q are as above defined, may be carried out as described in 1-i-2) using a ratio (IIIl)/(IVd) 1:2.

4f) The compounds of formula (Im) wherein X₁₂ is selected from (d7′) or (d8′) wherein R^(12a) is selected from D5) or D6), Q, Y and Y′ are as above defined, T″ is C(O)—X″, T′ and T″′ are C(O) or C(O)—X″, wherein X″ is as above defined, can be obtained 4f-i) by reacting a compound of formula (In)

P⁴—X₁₅  (In)

wherein P⁴ and X₁₅ are as above defined, with a compound of formula (IVd)

R_(a)—O—C(O)—X″-y-Q (IVd)

wherein R_(a), X″ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 4f-ii) when Q is Z₂, by converting the compounds obtained in the step 4f-i) into nitro derivative by reaction with a nitrate source as above described and 4f-iii) optionally deprotecting the compounds obtained in step 4f-i) or 4f-ii) as above described.

The reaction of a compound of formula (In) wherein P⁴ and X₁₅ are as above defined, with a compound of formula (IVd) wherein R_(a), X″, y and Q are as above defined, may be carried out as described in 1-i-2).

The compounds of formula (In) wherein T′ or T″′ are C(O), P⁴ and X₁₅ are as above defined are obtained as described in 4a-i), 4a-ii).

The compounds of formula (In) wherein T′ or T″′ are C(O)—X″, wherein P⁴ and X₁₅ are as above defined are obtained as described in 4b-i), 4b-ii).

4g) The compounds of formula (Im) wherein X₁₂ is selected from (d7′) or (d8′) wherein R^(2a) is selected from D5) or D6), Q, Y and Y′ are as above defined, T″ is C(O)—NR′—, T′ and T″′ are C(O) or C(O)—X″, wherein X″ is as above defined, can be obtained 4g-i) by reacting a compound of formula (In)

P⁴—X₁₅  (In)

wherein P⁴ and X₁₅ are as above defined, with a compound of formula

R_(a)—O—(O)C—NR′-y-Q  (IVf)

wherein R_(a), R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 4g-ii) when Q is Z₂, by converting the compounds obtained in the step 4g-i) into nitro derivative by reaction with a nitrate source as above described and 4g-iii) optionally deprotecting the compounds obtained in step 4g-i) or 4g-ii) as above described.

The reaction of a compound of formula (In) P⁴ and X₁₅ are as above defined, with a compound of formula (IVf) wherein R_(a), R′, y, Q are as above defined, may be carried out as described in 1-i-2).

The compounds of formula (In) wherein T′ or T″′ are C(O), wherein P⁴ and X₁₅ are as above defined, are obtained as described in 4a-i), 4a-ii).

The compounds of formula (In) wherein T′ or T″′ are C(O)—X″, wherein P⁴ and X₁₅ are as above defined, are obtained as described in 4b-i), 4b-ii).

4h) The compounds of formula (Im) wherein X₁₂ is selected from (d7′) or (d8′) wherein R^(12a) is selected from D7), Q, Y and Y′ are as above defined, T″ is X″, wherein X″ is as above defined, T′ and T″′ are C(O) or C(O)—X″, wherein X″ is as above defined, can be obtained 4h-i) by reacting a compound of formula (Ir),

P⁴—X_(16 (Ir))

wherein P⁴ is defined above and X₁₆ is the radical having the following meaning

(d7″″)—HN—CH(R^(12a)—OH)—CH₂—O-(T′-Y-Q)

(d8″″)—O—CH₂—CH(R^(2a)—OH)—NH-(T′-Y-Q)

wherein R^(12a) is selected from D7), with a compound of formula (IVe)

HX″-y-Q  (IVe)

wherein Y′, X″ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 4h-ii) when Q is Z₂, by converting the compounds obtained in the step 4h-i) into nitro derivative by reaction with a nitrate source as above described and 4h-iii) optionally deprotecting the compounds obtained in step 4h-i) or 4h-ii) as above described.

The reaction of a compound of formula (Ir) wherein P⁴ and X₁₆ are as above defined with a compound of formula (IVe) wherein y, X″ and Q are as above defined, may be carried out as described in 1-i-1).

The compounds of formula (Ir) wherein T′ or T″′ are C(O), P⁴ and X₁₆ are as above defined are obtained as described in 4a-i), 4a-ii).

The compounds of formula (Ir) wherein T′ or T″′ are C(O)—X″, P⁴ and X₁₆ are as above defined, are obtained as described in 4b-i), 4b-ii).

4i) The compounds of formula (Im) wherein X₁₂ is selected from (d7′) or (d8′) wherein R^(12a) is selected from D7), Q, Y and Y′ are as above defined, T″ is —NR′ wherein R′ is as above defined, T′ and T″′ are C(O) or C(O)—X″, wherein X″ is as above defined, can be obtained 4i-i) by reacting a compound of formula (Ir),

P⁴—X₁₆  (Ir)

wherein P⁴ and X₁₆ are as above defined and R^(12a) is selected from D7), with a compound of formula

HR′N-y-Q  (IVg)

wherein R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 4i-ii) when Q is Z₂, by converting the compounds obtained in the step 4i-i) into nitro derivative by reaction with a nitrate source such above described and 4i-iii) optionally deprotecting the compounds obtained in step 4i-i) or 4l-ii) as above described.

The reaction of a compound of formula (Ir) P⁴ and X₁₆ are as above defined, with a compound of formula (IVg) wherein R′, y, Q are as above defined, may be carried out as described in 1-i-1).

4l) The compounds of formula (Im) wherein X₁₂ is selected from (d7′) or (d8′) wherein R^(12a) is selected from D7), Q, Y and Y′ are as above defined, T″ is —O—CH(R′)—O—C(O)—, wherein R′ is as above defined, T′ and T″′ are C(O) or C(O)—X″, wherein X″ is as above defined, can be obtained 4l-i) by reacting a compound of formula (Ir),

P⁴—X₁₆  (Ir)

wherein P⁴ and X₁₆ are as above defined and R^(12a) is selected from D7), with a compound of formula (IVm)

Hal-CH(R′)—O—(O)C-y-Q  (IVm)

wherein R′ and Q are as above defined, Hal is an halogen atom, y is the radical Y′, wherein Y′ is as above defined, and 4l-ii) when Q is Z₂, by converting the compounds obtained in the step 4l-i) into nitro derivative by reaction with a nitrate source such above described and 4l-iii) optionally deprotecting the compounds obtained in step 4l-i) or 4l-ii) as above described.

The reaction of a compound of formula (Ir) wherein P⁴ and X₁₆ are as above defined, with a compound of formula (IVm) wherein y, Q, R′ are as above defined, may be carried out as described in 1l-i).

4m) The compounds of formula (Im) wherein X₁₂ is selected from (d7′) or (d8′) wherein R^(12a) is selected from D7), Q, Y and Y′ are as above defined, T″ is —O—CH(R′)—O—C(O)—O—, wherein R′ is as above defined, T′ and T″ are C(O) or C(O)—X″, wherein X″ is as above defined, can be obtained 4m-i) by reacting a compound of formula (Ir),

P⁴—X₁₆  (Ir)

wherein P⁴ and X₁₆ are as above defined and R^(12a) is selected from D7), with a compound of formula (IVo)

Hal-CH(R′)—O—(O)C—O-y-Q  (IVo)

wherein R and Q′ are as above defined, Hal is an halogen atom, y is the radical Y′, wherein Y′ is as above defined, and 4m-ii) when Q is Z₂, by converting the compounds obtained in the step 4m-i) into nitro derivative by reaction with a nitrate source as above described and 4m-iii) optionally deprotecting the compounds obtained in step 4m-i) or 4m-ii) as above described.

The reaction of a compound of formula (Ir) wherein P⁴ and X₁₆ are as above defined, with a compound of formula (IVo) wherein y, R′, Q, Hal are as above defined, may be carried out as described in 1l-i).

4n) The compounds of formula (Im) wherein X₁₂ is selected from (d3′) or (d4′) wherein R^(2a) is selected from D7), Y′ is as above defined, T″ is X″, wherein X″ is defined above, can be obtained 4n-i) by reacting a compound of formula (IIIm),

P⁴—X₁₇  (IIIm)

wherein P⁴ is defined above and X₁₇ is the radical

(d3″′) —HN—CH(R¹²—OH)—CH₂OP¹

(d4″′) —O—CH₂—CH(R^(2a)—OH)—NHR^(4a′)

wherein R^(12a) is selected from D7), wherein P¹ and R^(4a′) are as above defined, with a compound of formula (IVe)

HX″-y-Q  (IVe)

wherein X″ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 4n-ii) when Q is Z₂, by converting the compounds obtained in the step 4n-i) into nitro derivative by reaction with a nitrate source as above described and 4n-iii) optionally deprotecting the compounds obtained in step 4n-i) or 4n-ii) as above described.

The reaction of a compound of formula (IIIm) wherein P⁴ and X₁₇ are as above defined with a compound of formula (IVe) wherein y, X″ and Q are as above defined, may be carried out as described in 1-i-1).

The compounds of formula (IIIm), wherein P⁴ and X₁₇ are as above defined, are commercially available or obtained as known in literature.

4o) The compounds of formula (Im) wherein X₁₂ is selected from (d3′) or (d4′) wherein R^(12a) is selected from D7), Y′ is as above defined, T″ is —NR′ wherein R′ is as above defined, can be obtained 4o-i) by reacting a compound of formula (IIIm),

P⁴—X₁₇  (IIIm)

wherein P⁴ and X₁₇ are as defined above, wherein R^(12a) is selected from D7), with a compound of formula

HR′N-y-Q  (IVg)

wherein R′ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 4o-ii) when Q is Z₂, by converting the compounds obtained in the step 4o-i) into nitro derivative by reaction with a nitrate source such above described and 4o-iii) optionally deprotecting the compounds obtained in step 4o-i) or 4o-ii) as above described.

The reaction of a compound of formula (IIIm) wherein P⁴ and X₁₇ are as above defined, with a compound of formula (IVg) wherein R′, y, Q are as above defined, may be carried out as described in 1a-i).

4p) The compounds of formula (Im) wherein X₁₂ is selected from (d3′) or (d4′) wherein R^(12a) is selected from D7), Y′ is as above defined, T″ is —O—CH(R′)—O—C(O)— wherein R′ is as above defined, can be obtained 4p-i) by reacting a compound of formula (IIIm),

P⁴—X₁₇  (IIIm)

wherein P⁴ and X₁₇ are as defined above, wherein R^(12a) is selected from D7), with a compound of formula (IVm)

Hal-CH(R′)—O—(O)C-y-Q  (IVm)

wherein R′ and Q are as above defined, Hal is an halogen atom, y is the radical Y′, wherein Y′ is as above defined, and 4p-ii) when Q is Z₂, by converting the compounds obtained in the step 4p-i) into nitro derivative by reaction with a nitrate source such above described and 4p-iii) optionally deprotecting the compounds obtained in step 4p-i) or 4p-ii) as above described.

The reaction of a compound of formula (IIIm) wherein P⁴ and X₁₇ are as above defined, with a compound of formula (IVm) wherein R′, y, Q are as above defined, may be carried out as described in 1l-i).

4q) The compounds of formula (Im) wherein X₁₂ is selected from (d3′) or (d4′) wherein R^(12a) is selected from D7), Y′ is as above defined, T″ is —O—CH(R′)—O—C(O)—O— wherein R′ is as above defined, can be obtained 4q-i) by reacting a compound of formula (IIIm),

P⁴—X₁₇  (IIIm)

wherein P⁴ and X₁₇ are as defined above, wherein R^(12a) is selected from D7), with a compound of formula (IVo)

Hal-CH(R′)—O—(O)C—O-y-Q  (IVo)

wherein R′ and Q are as above defined, Hal is an halogen atom, y is the radical Y′, wherein Y′ is as above defined, and 4q-ii) when Q is Z₂, by converting the compounds obtained in the step 4q-i) into nitro derivative by reaction with a nitrate source as above described and 4q-iii) optionally deprotecting the compounds obtained in step 4q-i) or 4q-ii) as above described.

The reaction of a compound of formula (IIIm) wherein P⁴ and X₁₇ are as above defined, with a compound of formula (IVo) wherein y, R′, Q, Hal are as above defined, may be carried out as described in 1l-i).

5) The compounds of general formula (I) as above defined wherein a is equal to 0, R_(X) is a radical selected from (d5), (d6), (d9) or (d10), wherein R^(12b) is selected from D10) can be obtained 5-i) by reacting a compound of formula (II₁) as above defined with a compound of formula (Is)

W—X₁₈  (Is)

wherein W is as above defined, X₁₈ is the radical having the following meanings

(d5′) —R^(12b)—CH(NHR^(4a))—CH₂—O-(T″′-Y-Q)

(d6′) —R^(12b)—CH(CH₂OH)—NH-(T′-Y-Q)

(d9′) —R^(12b)—CH(NH-T″′-Y′-Q)-CH₂—O-(T′-Y-Q)

(d10′) —R^(12b)—CH(CH₂—O-T″′-Y′-Q)-NH-(T′-Y-Q)

wherein R^(12b) is selected from D10), T′, T″′, Y, Y′ and Q are as above defined and 5-ii) when Q is Z₂, by converting the compounds obtained in the step 5-i) into nitro derivative by reaction with a nitrate source as above described and 5-iii) optionally deprotecting the compounds obtained in step 5-i) or 5-ii) as above described.

The reaction of a compound of formula (II₃) as above defined, with a compound of formula (Is) wherein W and X₁₁ are as above defined may be carried out as described in 1).

5a) The compounds of formula (Is) wherein X₁₈ is a radical of formula (d5′) or (d6′), wherein R^(12b) is selected from D10), T′ and T″′ are C(O) can be obtained 5a-i) by reacting a compound of formula (IIIn),

P²—X₁₉  (IIIn)

wherein P² is as above defined, X₁₉ is the radical having the following meanings

(d5″) —R^(12b)—CH(NHP³)—CH₂—OH

(d6″) —R^(12b)—CH(CH₂OP¹)—NH₂

wherein P¹ and P³ are as above defined and R^(12b) is selected from D10), with a compound of formula (IVa)

W₁—C(O)-y-Q  (IVa)

wherein W₁, y, Q are as above defined, y is the radical Y, wherein Y is as above defined, and 5a-ii) when Q is Z₂, by converting the compounds obtained in the step 5a-i) into nitro derivative by reaction with a nitrate source as above described and 5a-iii) optionally deprotecting the compounds obtained in step 5a-i) or 5a-ii) as above described.

The reaction of a compound of formula (IIIn) wherein P² and X₁₉ are as above defined, with a compound of formula (IVa) W₁, y, and Q are as above defined may be carried out as described in 1-i-1), 1-i-2), 1-i-3) and 1a-1).

The compounds of formula (IIIn), wherein P² and X₁₉ are as above defined, are commercially available or obtained as known in literature.

5b) The compounds of formula (Is) wherein X₁₈ is a radical of formula (d5′) or (d6′), wherein R¹² is selected from D10), T′ and T″′ are C(O)—X″, wherein X″ is defined above, can be obtained 5b-i) by reacting a compound of formula (IIIn),

P²—X₁₉  (IIIn)

wherein P² and X₁₉ are as above defined, with a compound of formula (IVd)

R_(a)—O—C(O)—X″-y-Q  (IVd)

wherein R_(a) and Q, X″ are as above defined, y is the radical Y, wherein Y is as above defined, and 5b-ii) when Q is Z₂, by converting the compounds obtained in the step 5b-i) into nitro derivative by reaction with a nitrate source as above described and 5b-iii) optionally deprotecting the compounds obtained in step 5b-i) or 5b-ii) as above described.

The reaction of a compound of formula (IIIn) wherein P² and X₁₉ are as above defined, with a compound of formula (IVd) R_(a), y, Q, X″ are as above defined may be carried out as described in 1-i-2).

5c) The compounds of formula (Is) wherein X₁₈ is a radical of formula (d9′), wherein R^(12b) is selected from D10), Y and Y′ are as defined above, T′ is C(O)— and T″′ is C(O) or C(O)—X″, wherein X″ is defined above, can be obtained 5c-i) by reacting a compound of formula (It),

P²—X₂₀  (It)

wherein P² is as above defined and X₂₀ is the radical having the following meanings

(d9″) —R¹²—CH(NH₂)—CH₂—O-(T″′-Y-Q)

wherein R^(12b) is selected from D10), T″′, Y and Q are as above defined, with a compound of formula (IVa)

W₁—C(O)-y-Q  (IVa)

wherein W₁ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 5c-ii) when Q is Z₂, by converting the compounds obtained in the step 5c-i) into nitro derivative by reaction with a nitrate source as above described and 5c-iii) optionally deprotecting the compounds obtained in step 5c-i) or 5c-ii) as above described.

The reaction of a compound of formula (It) wherein P² and X₂₀ are as above defined, with a compound of formula (IVa) wherein W₁, y, Q are as above defined, may be carried out as described in 1-i-1), 1-i-2), 1-i-3) and 1a-1).

5d) The compounds of formula (Is) wherein X₁₈ is a radical of formula (d9′), wherein R^(12b) is selected from D10), T′ is C(O)—X″ and T″′ is C(O)— or C(O)—X″, wherein X″ is defined above, can be obtained 5d-i) by reacting a compound of formula (It),

P²—X₂₀  (It)

wherein P² and X₂₀ are as above defined, with a compound of formula (IVd)

R_(a)—O—C(O)—X″-y-Q  (IVd)

wherein R_(a) and Q, X″ are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 5d-ii) when Q is Z₂, by converting the compounds obtained in the step 5d-i) into nitro derivative by reaction with a nitrate source as above described and 5d-iii) optionally deprotecting the compounds obtained in step 5d-i) or 5d-ii) as above described.

The reaction of a compound of formula (It) wherein P² and X₂₀ are as above defined, with a compound of formula (IVd) R_(a), Y, Q, X″ are as above defined may be carried out as described in 1-i-2).

5e) The compounds of formula (Is) wherein X₁₈ is the radical of formula (d10′), wherein R^(12b) is selected from D10), Y and Y′ are as defined above, T″′ is C(O)— and T′ is C(O) or C(O)—X″, wherein X″ is defined above, can be obtained 5e-i) by reacting a compound of formula (It),

P²—X₂₀  (It′)

wherein P² is as above defined and X_(20′) is the radical having the following meaning

(d10″) —R^(12b)—CH(CH₂—OH)—NH-(T′-Y-Q)

wherein R^(12b) is selected from D10), T′, Y and Q are as above defined, with a compound of formula (IVa)

W₁—C(O)-y-Q  (IVa)

wherein W₁ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 5e-ii) when Q is Z₂, by converting the compounds obtained in the step 5e-i) into nitro derivative by reaction with a nitrate source as above described and 5e-iii) optionally deprotecting the compounds obtained in step 5e-i) or 5e-ii) as above described.

The reaction of a compound of formula (It′) wherein P² and X_(20′) are as above defined, with a compound of formula (IVa) wherein W₁, y, Q are as above defined, may be carried out as described in 1-i-1), 1-i-2), 1-i-3) and 1a-1).

5f) The compounds of formula (Is) wherein X₁₈ is the radical of formula (d10′), wherein R^(12b) is selected from D10), T″′ is C(O)—X″ and T′ is C(O)— or C(O)—X″, wherein X″ is defined above, can be obtained 5f-i) by reacting a compound of formula (It′),

P²—X_(20′)  (It′)

wherein P² and X_(20′) are as above defined, with a compound of formula (IVd)

R_(a)—O—C(O)—X″-y-Q  (IVd)

wherein R_(a) and Q, X″ are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 5f-ii) when Q is Z₂, by converting the compounds obtained in the step 5f-i) into nitro derivative by reaction with a nitrate source as above described and 5f-iii) optionally deprotecting the compounds obtained in step 5f-i) or 5f-ii) as above described.

The reaction of a compound of formula (It′) wherein P² and X_(20′) are as above defined, with a compound of formula (IVd) R_(a), Y, Q, X″ are as above defined may be carried out as described in 1-i-2).

6) The compounds of general formula (I) as above defined wherein a is equal to 1, R_(X) is a radical selected from (d5), is (d6), (d9) or (d10), wherein R^(12b) is selected from D10), Z is —CH(R′)—O—, wherein R′ is defined above, can be obtained 6-i) by reacting a compound of formula (II₁) as above defined with a compound of formula (Iu)

Hal-CH(R′)—O—X₂₁  (Iu)

wherein Hal is an halogen atom, R′ is as above defined and X₂₁ is a radical selected from (d5′), (d6′), (d9′) or (d10′), wherein R^(12b) is selected from D10), and 6-ii) when Q is Z₂, by converting the compounds obtained in the step 6-i) into nitro derivative by reaction with a nitrate source as above described and 6-iii) optionally deprotecting the compounds obtained in step 6-i) or 6-ii) as above described.

The reaction of a compound of formula (Iu) wherein Hal, X₂₁ and R′ are as above defined, with a compound of formula (II₁) as above defined may be carried out as described in 1l-i).

The compounds of formula (Iu) are obtained by reacting a compound R′—CHO, wherein R′ is as above defined with compounds of formula (IIIo)

W—X₂₂  (IIIo)

wherein W is a chlorine atom, X₂₂ is the radical having the following meanings

(d5″′) —R^(12b)—CH(NHP³)—CH₂—O-(T″′-Y-Q)

(d6″′) —R^(12b)—CH(CH₂OP¹)—NH-(T′-Y-Q)

(d9″′) —R^(12b)—CH(NH-T′-Y′-Q)-CH₂—O-(T″′-Y-Q)

(d10″′) —R^(12b)—CH(CH₂—O-T″′-Y′-Q)-NH-(T′-Y-Q)

wherein R^(12b), P³, P¹, T′, T″′, Y′, Y and Q are as above defined, and ZnCl₂ as known in literature.

The compounds of formula (IIIo), wherein W and X₂₂ are as above defined, may be carried out as described in 5).

7) The compounds of general formula (I) as above defined wherein a is equal to 1, R_(X) is a radical selected from (d5), (d6), (d9) or (d10), wherein R^(12b) is selected from D8) or D9), Z is —C(O)—, can be obtained 7-i) by reacting a compound of formula (II₃) as above defined wherein R_(a) is as above defined with a compound of formula (Iv)

H—X₂₃  (Iv)

wherein X₂₃ is a radical selected from (d5′), (d6′), (d9′) or (d10′), wherein R^(12b) is selected from D8) or D9), and 7-ii) when Q is Z₂, by converting the compounds obtained in the step 7-i) into nitro derivative by reaction with a nitrate source as above described and 7-iii) optionally deprotecting the compounds obtained in step 7-i) or 7-ii) as above described.

The reaction of a compound of formula (Iv) wherein X₂₃ and is as above defined, with a compound of formula (II₃) as above defined may be carried out as described in 1l-i).

8) The compounds of general formula (I) as above defined wherein a is equal to 0, R_(x) is a radical selected from (a5), (a6), (a9) or (a10), (b5), (b6), (b9) or (b10) wherein R^(1b) is selected from A10) and R^(2b) is selected from B10), can be obtained 8-i) by reacting a compound of formula (II₁) as above defined with a compound of formula (Iz)

W—X₂₄  (Iz)

wherein W is as above defined, X₂₄ is the radical R_(X) having the following meanings

(a5′) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y-Q)

(a6′) —R^(1b)—CH(COOR^(3a))NH-(T′-Y-Q)

(a9′) —R^(1b)—CH(NH-T′-Y′-Q)-C(O)-(T-Y-Q)

(a10′) —R^(1b)—CH(C(O)-T′-Y′-Q)-NH-(T-Y-Q)

(b5′) —R^(2b)—CH(NHR^(4a))—CH₂C(O)-(T-Y-Q)

(b6′) —R^(2b)—CH(CH₂COOR^(3a))NH-(T′-Y-Q)

(b9′) —R^(2b)—CH(NH-T′-Y′-Q)-CH₂C(O)-(T-Y-Q)

(b10′) —R^(2b)—CH(CH₂C(O)-T′-Y′-Q)-NH-(T-Y-Q)

wherein R^(1b) is selected from A10), R^(2b) is selected from B10), T, T′, Y and Q are as above defined and 8-ii) when Q is Z₂, by converting the compounds obtained in the step 8-i) into nitro derivative by reaction with a nitrate source as above described and 8-iii) optionally deprotecting the compounds obtained in step 8-i) or 8-ii) as above described.

The reaction of a compound of formula (II₁) as above defined wherein R is as above defined, with a compound of formula (Iv) wherein W and X₂₄ are as above defined may be carried out as described in 1).

8a) The compounds of formula (Iz) wherein X₂₄ is a radical of formula (a5′), (a6′), (b5′) or (b6′), wherein R^(1b) is selected from A10) and R^(2b) is selected from B10), T and T′ are C(O) can be obtained 8a-i) by reacting a compound of formula (IIIq),

P²—X₂₅  (IIIq)

wherein P² is as above defined, X₂₅ is the radical having the following meanings

(a5″) —R^(1b)—CH(NHP³)—C(O)—OH

(a6″) —R^(1b)—CH(COOP²)—NH₂

(b5″) —R^(2b)—CH(NHP³)—CH₂C(O)—OH

(b6″) —R^(2b)—CH(CH₂COOP²)NH₂

wherein P² and P³ are as above defined and R^(1b) is selected from A10), R^(2b) is selected from B10), with a compound of formula (IVa)

W₁—C(O)-y-Q  (IVa)

wherein W₁ and Q are as above defined, y is the radical Y, wherein Y is as above defined, and 8a-ii) when Q is Z₂, by converting the compounds obtained in the step 8a-i) into nitro derivative by reaction with a nitrate source as above described and 8a-iii) optionally deprotecting the compounds obtained in step 8a-i) or 8a-ii) as above described.

The reaction of a compound of formula (IIIq) wherein P² and X₂₅ are as above defined, with a compound of formula (IVa) W₁, Y, and Q are as above defined may be carried out as described in 1-i-1), 1-i-2), 1-i-3) and 1a-1).

The compounds of formula (IIIq), wherein P² and X₂₅ are as above defined, are commercially available or obtained as known in literature.

8b) The compounds of formula (Iz) wherein X₂₄ is the radical of formula (a5′), (a6′), (b5′) or (b6′), wherein R^(1b) is selected from A10) and R^(2b) is selected from B10), T and T′ are C(O)—X″, wherein X″ is defined above, can be obtained 8b-i) by reacting a compound of formula (IIIq),

P²—X₂₅  (IIIq)

wherein P² and X₂₅ are as above defined, with a compound of formula (IVd)

R_(a)—O—C(O)—X″-y-Q  (IVd)

wherein R_(a), Q and X″ are as above defined, y is the radical Y, wherein Y is as above defined, and 8b-ii) when Q is Z₂, by converting the compounds obtained in the step 8b-i) into nitro derivative by reaction with a nitrate source as above described and 8b-iii) optionally deprotecting the compounds obtained in step 8b-i) or 8b-ii) as above described.

The reaction of a compound of formula (IIIq) wherein P² and X₂₅ are as above defined, with a compound of formula (IVd) R_(a), y, Q, X″ are as above defined may be carried out as described in 1-i-2).

8c) The compounds of formula (Iz) wherein X₂₄ is the radical of formula (a9′) or (b9′) wherein R^(1b) is selected from A10), and R^(2b) is selected from B10) Y and Y′ are as defined above, T is C(O)— or C(O)—X″, wherein X″ is defined above and T′ is C(O) can be obtained 8c-i) by reacting a compound of formula (Iy),

P²—X₂₆  (Iy)

wherein P² is as above defined and X₂₆ is the radical having the following meanings

(a9″) —R^(1b)—CH(NH₂)—C(O)-(T-Y-Q)

(b9″) —R^(2b)—CH(NH₂)—CH₂C(O)-(T-Y-Q)

wherein R^(1b) is selected from A10) and R^(2b) is selected from B10), with a compound of formula (IVa)

W₁—C(O)-y-Q  (IVa)

wherein W₁ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 8c-ii) when Q is Z₂, by converting the compounds obtained in the step 8c-i) into nitro derivative by reaction with a nitrate source as above described and 8c-iii) optionally deprotecting the compounds obtained in step 8c-i) or 8c-ii) as above described.

The reaction of a compound of formula (Iy) wherein P² and X₂₆ are as above defined, with a compound of formula (IVa) wherein W₁, y, Q are as above defined, may be carried out as described in 1-i-1), 1-i-2), 1-i-3) and 1a-1).

8d) The compounds of formula (Iz) wherein X₂₄ is the radical of formula (a9′) or (b9′) wherein R^(1b) is selected from A10), R^(2b) is selected from B10), Y and Y′ are as defined above, T is C(O)— or C(O)—X″, wherein X″ is defined above and T′ is C(O)—X″ can be obtained 8d-i) by reacting a compound of formula (Iy),

P²—X₂₆  (Iy)

wherein P² and X₂₆ are as above defined, with a compound of formula (IVd)

R_(a)—O—C(O)—X″-y-Q  (IVd)

wherein R_(a) and X″ are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 8d-ii) when Q is Z₂, by converting the compounds obtained in the step 8d-i) into nitro derivative by reaction with a nitrate source as above described and 8d-iii) optionally deprotecting the compounds obtained in step 8d-i) or 8d-ii) as above described.

The reaction of a compound of formula (Iy) wherein P² and X₂₀ is are as above defined, with a compound of formula (IVd) R_(a), Y, Q, X″ are as above defined may be carried out as described in 1-i-2).

8e) The compounds of formula (Iz) wherein X₂₄ is the radical of formula (a10′) or (b10′) wherein R^(1b) is selected from A10), and R^(2b) is selected from B10) Y and Y′ are as defined above, T is C(O)— or C(O)—X″, wherein X″ is defined above and T′ is C(O) can be obtained 8e-i) by reacting a compound of formula (Iy′),

P²—X₂₆  (Iy′)

wherein P² is as above defined and X₂₆ is the radical having the following meanings

(a10″) —R^(1b)—CH(C(O)—OH)—NH-(T-Y-Q)

(b10″) —R^(2b)—CH(CH₂C(O)—OH)—NH-(T-Y-Q)

wherein R^(1b) is selected from selected from A10) and R^(2b) is B10), with a compound of formula (IVa)

W₁—C(O)-y-Q  (IVa)

wherein W₁ and Q are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 8e-ii) when Q is Z₂, by converting the compounds obtained in the step 8e-i) into nitro derivative by reaction with a nitrate source as above described and 8e-iii) optionally deprotecting the compounds obtained in step 8e-i) or 8e-ii) as above described.

The reaction of a compound of formula (Iy′) wherein P² and X_(26′) are as above defined, with a compound of formula (IVa) wherein W₁, y, Q are as above defined, may be carried out as described in 1-i-1), 1-i-2), 1-i-3) and 1a-1).

8f) The compounds of formula (Iz) wherein X₂₄ is the radical of formula (a10′) or (b10′) wherein R^(1b) is selected from A10), and R^(2b) is selected from B10), Y and Y′ are as defined above, T is C(O)— or C(O)—X″, wherein X″ is defined above and T′ is C(O)—X″ can be obtained 8f-i) by reacting a compound of formula (Iy′),

P²—X_(26′)  (Iy′)

wherein P² and X_(26′) are as above defined, with a compound of formula (IVd)

R_(a)—O—C(O)—X″-y-Q  (IVd)

wherein R_(a) and X″ are as above defined, y is the radical Y′, wherein Y′ is as above defined, and 8f-ii) when Q is Z₂, by converting the compounds obtained in the step 8f-i) into nitro derivative by reaction with a nitrate source as above described and 8f-iii) optionally deprotecting the compounds obtained in step 8f-i) or 8f-ii) as above described.

The reaction of a compound of formula (Iy′) wherein P² and X₂₆ are as above defined, with a compound of formula (IVd) R_(a), y, Q, X″ are as above defined may be carried out as described in 1-i-2).

9) The compounds of general formula (I) as above defined wherein a is equal to 1, R_(X) is a radical selected from (a5), (a6), (a9) or (a10), (b5), (b6), (b9) or (b10) wherein R^(1b) is selected from A8) or A9), R^(2b) is selected from B8) or B9), Z is —C(O)—, can be obtained 9-i) by reacting a compound of formula (II₃) as above defined with a compound of formula (Ix)

H—X₂₇  (Ix)

wherein X₂₇ is the radical selected from (a5′), (a6′), (a9′), (a10′), (b5′), (b6′), (b9′) or (b10′), wherein R^(1b) is selected from A8) or A9), R^(2b) is selected from B8) or B9), and 9-ii) when Q is Z₂, by converting the compounds obtained in the step 9-i) into nitro derivative by reaction with a nitrate source as above described and 9-iii) optionally deprotecting the compounds obtained in step 9-i) or 9-ii) as above described.

The reaction of a compound of formula (Ix) wherein X₂₇ and is as above defined, with a compound of formula (II₃) may be carried out as described in 1l-i).

EXAMPLE 1 Synthesis of (11β,16β)-9-Chloro-11,17-dihydroxy-16-methyl-21-[1-oxo-((2-(4-(nitrooxy)butyloxy-carbonylamino)acetyl)]-pregna-1,4-diene-3,20-dione

(11β,16β)-9-Chloro-11,17-dihydroxy-16-methyl-21-[1-oxo-2-((tert-butylcarbonylamino)acetyl)]-pregna-1,4-diene-3,20-dione

To a solution of beclomethasone (0.6 g, 1.46 mmol) in acetone (35 ml), N-Boc-glycine (0.334 g, 1.90 mmol) and DMAP (cat. amount) were added. The reaction was cooled at 0° C. and EDAC (0.365 g, 1.90 mmol) was added. The reaction was stirred at room temperature for 2 hours. The solvent was evaporated under vacuum. The residue was treated with water (50 ml) and methylene chloride (50×3 ml), the organic layers were dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by flash chromatography, eluent n-hexane/ethyl acetate 6/4. The product (0.8 g) was obtained.

(11β,16β)-9-Chloro-11,17-dihydroxy-16-methyl-21-[1-oxo-2-((carbonylamino)acetyl)]-pregna-1,4-diene-3,20-dione hydrochloride

A solution of compound A (0.8 g, 0.41 mmol) in methylene chloride (70 ml) was stirred at room temperature. HCl gas was buddle in the solution for 1 hour. The solvent was evaporated under reduced pressure. The product was used in the next step without any purification.

(11β,16β)-9-Chloro-11,17-dihydroxy-16-methyl-21-[1-oxo-(2-((4-(nitrooxy)butoxy-carbonylamino)acetyl)]-pregna-1,4-diene-3,20-dione

To a solution of B) (0.75 g, 1.46 mmol) in methylene chloride (40 ml), 4-nitrooxybutyric acid pentafluorophenyl ester (0.41 g, 1.46 mmol), DMAP (cat. amount) and triethylamine (0.3 ml, 2.19 mmol) were added. The reaction was stirred at room temperature for 24 hours. The solution was treated with a 5% solution of H₃PO₄ (50 ml). The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by flash chromatography, (Biotage System, column FLASH 40+M™ KP-Sil) eluent:gradient n-hexane/ethyl acetate 1/1 (130 ml), to ethyl acetate 100% during 130 ml, ethyl acetate 100% (130 ml). The product (0.62 g) was obtained as white powder.

¹H-NMR: (DMSO), δ: 8.42 (1H, t); 7.30 (1H, d); 6.22 (1H, dd); 5.98 (1H, s); 5.46 (1H, d); 5.42 (2H, s); 5.05 (1H, d); 4.84 (1H, d); 4.5 (2H, t); 4.34 (1H, sb); 3.97 (2H, d); 2.71-2.57 (2H, m); 2.5-2.2 (6H, m); 2.0-1.7 (5H, m); 1.65-1.35 (5H, m); 1.25-0.97 (4H, m); 0.8 (3H, s). 

1. Nitric oxide releasing compounds of general formula (I) R-(Z)_(a)-R_(X)  (I) and pharmaceutically acceptable salts or stereoisomers thereof for use in the treatment of respiratory diseases, wherein in formula (I) R is a corticosteroid residue selected from:

a is 0 or 1, Z is a group capable of binding R_(X) and is selected from —C(O)—, or —CH(R′)—O— wherein R′ is selected from H or a straight or branched C₁-C₄ alkyl, preferably R′ is H or —CH₃; R_(x) is a radical selected from the following meanings: A) (a1) —HN—CH(R¹)—C(O)-(T-Y—ONO₂) (a2) —C(O)—CH(R¹)—NH-(T′-Y—ONO₂) (a3) —HN—CH(R^(1a)-T″-Y′—ONO₂)COOR^(3a) (a4) —C(O)—CH(R^(1a)-T″-Y—ONO₂)—NHR^(4a) (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) (a6) —R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂) (a7) —HN—CH(R^(1a)-T″-Y′—ONO₂)—C(O)-(T-Y—ONO₂) (a8) —C(O)—CH(R^(1a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—(O)-(T-Y—ONO₂) (a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein: R¹ is selected from: A1) H, —CH₃, isopropyl, isobutyl, sec-butyl, tert-butyl, methylthio-(CH₂)₂—, phenyl, benzyl, C₆H₅—CH₂—CH₂—, 2-monosubstituted benzyl, or 3-monosubstituted benzyl or 4-monosubstituted benzyl wherein the substituent of the benzyl is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN, C₆H₅CO—, 2,4-dichlorobenzyl, 3,4-dichlorobenzyl, 3,4-difluorobenzyl, 2-pyrrolidyl, 3-triptophanyl-CH₂—, 3-benzothienyl-CH₂—, 4-imidazolyl-CH₂—, 9-anthranyl-CH₂—, cyclohexyl, cyclohexyl-CH₂—, cyclohexyl-(CH₂)₂—, cyclopentyl-CH₂—, (C₆H₅)₂CH—, 4-B(OH)₂-benzyl, 4-quinolyl-CH₂—, 3-quinolyl-CH₂—, 2-quinolyl-CH₂—, 2-quinoxalyl-CH₂—, 2-furyl-CH₂—, 1-naphtyl-CH₂—, 2-naphtyl-CH₂—, 2-pyridyl-CH₂—, 3-pyridyl-CH₂—, 4-pyridyl-CH₂—, 2-thienyl-CH₂—, 3-thienyl-ClF₂—, C₆H₄—CH═CH—CH₂—, CH₂═CH—CH₂—, CH═CH—CH₂—, NH₂—CO—CH₂—, NH₂—CO—(CH₂)₂—, NH₂(═NH)NH—(CH₂)₃—, P(═O)(OCH₃)₂; A2) —CH₂—SH, —CH₂—OH, —CH(CH₃)—OH, —OCH₂—[(C₆H₄)-(4-OH)], —CH₂—[(C₆H₂)-(3,5-diiodo)-(4-OH)],  —CH₂—[(C₆H₃)-(3-nitro)-(4-OH)], A3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, —C(O)CH₃ or

wherein R^(5a) is H or a linear or branched C₁-C₁₀ alkyl chain, A4) —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is —OR^(5a) or

wherein R^(5a) is as above defined; R^(1a) is selected from, A5) —CH₂—S—, —CH₂—O—, —CH(CH₃)—O—, —CH₂[(C₆H₄)-(4-O)—], —CH₂-[(3,5-diiodo)-(C₆H₂)-(4-O)—],  —CH₂-[(3-nitro)-(C₆H₃)-(4-O)—], A6) —CH₂—NH—, —(CH₂)₂—NH—, —(CF₁₂)₃—NH—, —(CH₂)₄—NH—, A7) —CH₂—C(O)—, —(CH₂)₂—C(O), —(CH₂)₄—C(O)—; R^(3a) is selected from H, —R^(5a) or

wherein R^(5a) is as above defined, R^(4a) is selected from H or —C(O)CH₃ or

wherein R^(5a) is as above defined, R^(1b) is selected from A8) —S—CH₂—, —O—CH(CH₃)—, —O—CH₂—, [-(4-O)—(C₆H₄)]—CH₂—, [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂—,  [-(4-O)-(3-nitro)-(C₆H₃)]—CH₂—, A9) —HN—CH₂—, —HN—(CH₂)₂—, —HN—(CH₂)₃—, —HN—(CH₂)₄—, A10) —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, T is selected from —O—, —S—, NR′—, —O—CH(R′)—O—C(O)— or  —O—CH(R′)—O—C(O)O— wherein R′ is as above defined, T′ is —C(O)—, —C(O)—X″— wherein X″ is —O— or —S—, or T′ is  —C(O)—NR′— wherein R′ is as above defined, T″ is independently selected from —C(O)—, —C(O)—X″—,  —C(O)—NR′—, —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—,  —O—CH(R′)—O—C(O)O—, wherein X″ and R′ are as above defined, with the proviso that T″ is —C(O)—, —C(O)—X″— or —C(O)—NR′— when T″ is linked to —NH—, —O—, or —S—, or T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—, —O—CH(R′)—O—C(O)O— when T″ is linked to —C(O)—, Y and Y′ are as below defined; or R_(x) is selected from: B) (b1) —HN—CH(R²)—CH₂—C(O)-(T-Y—ONO₂) (b2) —C(O)—CH₂—CH(R²)—NH-(T′-Y—ONO₂) (b3) —HN—CH(R^(2a)-T″-Y′—ONO₂)—CH₂COOR_(3a) (b4) —C(O)—CH₂—CH(R^(2a)-T″-Y′—ONO₂)—NHR^(4a) (b5) —R^(2b)—CH(NHR^(4a))—CH₂—C(O)-(T-Y—ONO₂) (b6) —R^(2b)—CH(CH₂COOR^(3a))NH-(T-Y—ONO₂) (b7) —HN—CH(R^(2a)-T″-Y′—ONO₂)—CH₂—C(O)-(T-Y—ONO₂) (b8) —C(O)CH₂—CH(R^(2a)-T″Y′—ONO₂)—NH-(T′-Y—ONO₂) (b9) —R^(2b)—CH(NH-T′-Y′—ONO₂)—CH₂C(O)-(T′-Y—ONO₂) (b10) —R^(2b)—CH(CH₂C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R² is selected from B1) H, —CH₃, CF₃, isopropyl, isobutyl, sec-butyl, methylthio-(CH₂)₂—, phenyl, benzyl, 3-triptophanyl-CH₂—, NH₂—C(O)—CH₂—,  NH₂—C(O)—(CH₂)₂—, NH₂(═NH)NH—(CH₂)₃—, tBuO—CH(CH₃)—,  benzyl-O—CH₂—,  4-terbutoxy-benzyl, 4-phenylbenzyl, B2) —CH₂—SH, —CH₂—OH, —CH(CH₃)—OH, —CH₂—[(C₆H₄)-(4-OH)], —CH₂—[(C₆H₂)-(3,5-diiodo)-(4-OH)],  —CH₂—[(C₆H₃)-(3-nitro)-(4-OH)], B3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is as above defined, B4) —CH₂—C(O)—R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)—R″′ wherein R″′ is as above defined, preferably R² is —CH₂—C(O)—R″′; R^(2a) is selected from: B5) —CH₂—S—, —CH₂—O—, —CH(CH₃)O— or —CH₂—[(C₆H₄)-(4-O)—], —CH₂-[(3,5-diiodo)-(C₆H₁₂)-(4-O)—],  —CH₂-[(3-nitro)-(C₆H₃)-(4-O)—], B6) —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, B7) —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, R^(2b) is selected from. B8) —S—CH₂—, —O—CH(CH₃)—, —O—CH₂—, [-(4-O)—(C₆H₄)]—CH₂—, [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂—, [-(4-O)-(3-nitro)-(C₆H₃)]—CH₂, B9) —HN—CH₂—, —HN—(CH₂)₂—, —HN—(CH₂)₃—, —HN—(CH₂)₄—, B10) —C(O)—CH₂—, —C(O)—(CH₂)₂—, C(O)—(CH₂)₄—, R^(3a) and R^(4a) are as above defined, T, T′ and T″ are as above defined and Y and Y′ are as below defined; or R_(x) is selected from: C) (c1) —HN—(CH₂)_(b)—C(O)-(T′-Y—ONO₂) or (c2) —C(O)—(CH₂)_(b)—NH-(T′-Y—ONO₂) wherein b is an integer from 3 to 6, T and T′ are as above defined and Y and Y′ are as below defined; or R_(x) is selected from: D) (d1) —HN—CH(R¹²)—CH₂—O-(T″′-Y—ONO₂) (d2) —O—CH₂—CH(R¹²)—NH-(T′-Y—ONO₂) (d3) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂OH (d4) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NHR^(4a) (d5) —R^(12b)—CH(NHR^(4a))—CH₂—O-(T″′-Y—ONO₂) (d6) —R^(12b)—CH(CH₂OH)—NH-(T′-Y—ONO₂) (d7) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) (d8) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) (d9) —R^(12b)—CH(NH-T′-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) or (d10) —R^(12b)—CH(CH₂—O-T″′-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein T″′ is independently selected from —C(O)—, —C(O)X″— wherein X″ is —O— or —S—, or —C(O)—NR′— wherein R′ is as above defined, T′ and T″ are as above defined, Y and Y′ are as below defined, R¹² is selected from: D1) H, —CH₃, isopropyl, isobutyl, sec-butyl, methylthio-(CH₂)₂—, benzyl, 3-triptophanyl-CH₂—, 4-imidazolyl-CH₂—,  NH₂—CO—CH₂—, NH₂—CO—(CH₂)₂—, NH₂(═NH)NH—(CH₂)₃—; D2) —CH₂—OH, —CH(CH₃)—OH, —CH₂—[(C₆H₄)-(4-OH)],  —CH₂—[(C₆H₃)-(3,5-diiodo)-(4-OH)],  —CH₂—[(C₆H₃)-(3-nitro)-(4-OH)], D3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is as above defined, preferably R¹² is —(CH₂)₄—NHR″; D4) —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, (CH₂)₄—C(O)R″′ wherein R″′ is as above defined, R^(12a) is selected from: D5) —CH₂—O—, —CH(CH₃)—O— or —CH₂—[(C₆H₄)-(4-O)—],  —CH₂-[3,5-diiodo-(C₆H₂)-(4-O)—], —CH₂-[3-nitro-(C₆H₃)-4-O—], D6) —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, D7) —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—O(O)—, R^(12b) is selected from: D8) —O—CH₂—, —O—CH(CH₃)—, [-(4-O) (C₆H₄)]—CH₂—,  [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂, [-(4-O)-(3-nitro)-(C₆H₃)]—CH₂—, D9) —HN—CH₂—, —HN—(CH₂)₂—, —HN—(CH₂)₃—, —HN—(CH₂)₄—, D10) —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, R^(4a) is as above defined; or R_(X) is selected from: E)

wherein c is equal to 0 or 1, d is an integer from 0 to 3 with the proviso that c is 0 or 1 when d is 0 and c is 0 when d is 1, 2 or 3, T and T′ are as above defined and Y is as below defined; F)

(XI) wherein e and f are equal to 0 or 1, with the proviso that f is 0 when e is 0 and f is 0 or 1 when e is 1, T and t′ are as above defined and y is as below reported; G)

wherein R³ is H, CH₃, propyl, (C₆H₅)₂CH—, 1-naphtyl-CH₂—, benzyl, allyl, 2-bromobenzyl, 2-chlorobenzyl, 3-chlorobenzyl, 4-fluorobenzyl, 4-bromobenzyl, 4-methylbenzyl, T and T′ are as above defined and Y is as below defined; H)

wherein R⁴ is H, benzyl, 4-bromobenzyl, 2-bromobenzyl, T and T′ are as above defined and Y is as below defined; I)

wherein R⁵ is H, R⁶ is H, or R⁵ and R⁶ when taken together are a double bond, T and T′ are as above defined and Y is as below reported; L)

wherein T and T′ are as above defined and Y is as below reported; M)

wherein T and T′ are as above defined and Y is as below reported; N)

wherein c is as above defined, d is equal to 0 or 1, T and T′ are as above defined and Y is as below reported; O)

wherein R⁷ is H, R⁸ is H, or R⁷ and R⁸ when taken together are a double bond, c is as above defined, T and T′ are as above defined and Y is as below reported; P)

wherein T and T′ are as above defined and Y is as below reported; Q)

wherein T and T′ are as above defined and Y is as below reported; R)

wherein T and T′ are as above defined and Y is as below reported; S)

wherein T and T′ are as above defined and Y is as below reported; T)

wherein T and T′ are as above defined and Y is as below reported; U)

wherein R⁹ and R¹⁰ are H, CH₃, R¹¹ is CH₃ or 4-piperidinyl with the proviso that R⁹ and R¹⁰ are H when R¹¹ is 4-piperidinyl and R⁹ and R¹⁰ are CH₃ when R¹¹ is CH₃, T and T′ are as above defined and Y is as below reported; V)

wherein T and T′ are as above defined and Y is as below reported; with the proviso that in the formula (I): a is 0 or a is 1 and Z is CH(R′)—O— wherein R′ is as above defined, when R_(x) is: (a2), (a4) or (a8); (a5), (a6), (a9) or (a10) and R^(1b) is selected from the group A10); (b2), (b4) or (b8); (b5), (b6), (b9) or (b10) and R^(2b) is selected from the group B10); (c2); (d5), (d6), (d9) or (d10) and R^(12b) is selected from the group D10); (e2), (f1), (g2), (h1), (i1), (l2), (m2), (n2), (o2), (p2), (q2), (r2), (s2), (t1) or (u2); a is 1 and Z is —C(O)—, when R_(x) is: (a1), (a3) or (a7); (a5), (a6), (a9) or (a10) and R^(1b) is selected from the groups A8) and A9); (b1), (b3) or (b7); (b5), (b6), (b9) or (b10) and R^(2b) is selected from the groups B8) or B9); (c1); (d1), (d2), (d3), (d4), (d7) or (d8); (d5), (d6), (d9) or (d10) and R^(12b) is selected from the groups D8) or D9); (e1), (f2), (g1), (h2), (i2), (l1), (m1), (n1), (o1), (p1), (q1), (r1), (s1), (t2) or (u1). Y and Y′ are bivalent radicals each independently selected from the following meanings: a) straight or branched C₁-C₂₀ alkylene, straight or branched C₁-C₂₀ alkylene substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, —ONO₂ or T₂, wherein T₂ is —OC(O)(C₁-C₁₀ alkyl)-ONO₂ or —O(C₁-C₁₀ alkyl)-ONO₂; cycloalkylene with 5 to 7 carbon atoms into cycloalkylene ring, the ring being optionally substituted with one or more straight or branched C₁-C₁₀ alkyl chains; b)

wherein n⁰ is an integer from 0 to 20; n¹ is 0 or 1; U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group; c)

wherein n⁰ is an integer from 0 to 20; n¹ is 0 or 1; U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group; d)

wherein: n² is an integer from 0 to 2, R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—; n¹ and U are as above defined; e)

n² is an integer from 0 to 2, R¹³ is H or CH₃, Y¹ is —CH₂—CH₂— or —CH═CH—(CH₂)_(n) ^(2′)—, wherein n^(2′) is 0 or 1, T₁=—O—C(O)— or —C(O)O—, n¹ is 0 or 1, preferably n¹ is 1, U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group; e′)

wherein: n² is an integer from 0 to 2, R¹³ is H or CH₃, Y¹ is —CH₂—CH₂— or (CH₂)_(n) ^(2′)—CH═CH—, wherein n^(2′) is 0 or 1, (T₁)′=—O—C(O)—; n¹ is 0 or 1, U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group; f)

wherein T₂ is —O— or —S—, —NH—, preferably T₂ is —O—, n³ is an integer from 1 to 6; when Y and Y′ are selected from b), c), d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T′-Y—ONO₂), -(T″-Y′—ONO₂), -(T′-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group; g)

wherein: n⁴ is an integer from 0 to 10, n⁵ is an integer from 1 to 10, R¹⁴, R¹⁵, R¹⁶, R¹⁷ are the same or different, and are H or straight or branched C₁-C₄ alkyl, wherein the —ONO₂ group is linked to

wherein n⁵ is as defined above; Y² is an heterocyclic saturated, unsaturated or aromatic 5 or 6 members ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulphur, and is selected from the group consisting of:


2. The nitric oxide releasing compounds according to claim 1 wherein a is 1 and Z is —C(O)—; R_(X) is (a1) —HN—CH(R¹)—C(O)-(T-Y—ONO₂) wherein R¹ of the group A1) is selected from H, isobutyl, benzyl, C₆H₅—CH₂—CH₂—, 2-monosubstituted benzyl, or 3-monosubstituted benzyl or 4-monosubstituted benzyl wherein the substituent of the benzyl is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN, C₆H₅CO— or R¹ of the group A2) is selected from —CH₂—OH, —CH(CH₃)—OH— or —CH₂—[(C₆H₄)-(4-OH)], or R¹ of the group A3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″,  —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, or —C(O)CH₃, R¹ of the group A4) is —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′,  —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl, T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, Y is as below defined; or R_(X) is (a3) —HN—CH(R^(1a)-T″-Y′—ONO₂)—COOR^(3a) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)O— or  —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—,  —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, R^(3a) is H or a (C₁-C₅) alkyl, T″ is —C(O)— or —C(O)—X″ wherein X″ is S— or —O—, when R^(1a) is selected from the group A5) or A6), T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, when R^(1a) is selected from the group A7), Y′ is as below defined; or R_(X) is selected from: (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) (a6) —R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂) (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) or (a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1b) of the group A8) is selected from —O—CH(CH₃)—, —O—CH₂—,  [-4-O)—(C₆H₄)]—CH₂—, or R^(1b) of the group A9) is selected from —HN—CH₂—, —HN—(CH₂)₂—,  —HN—(CH₂)₃—, —HN—(CH₂)₄, R^(1b) of the group A10) is —O—CH₂ or [-4-O—(C₆H₄)]—CH₂—, R^(3a) is H or a (C₁-C₅) alkyl, R^(4a) is H or —C(O)CH₃, T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, Y and Y′ are as below defined; or R_(X) is (a7) —HN—CH(R^(1a)-T″-Y′—ONO₂)—C(O)-(T-Y—ONO₂) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)—O— or  —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—,  —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, when R^(1a) is selected from A5) or A6); T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, when R^(1a) is selected from A7), T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, Y and Y′ are as below defined; or R_(X) is (b1) —HN—CH(R²)—CH₂C(O)-(T-Y—ONO₂) wherein R² of the group B1) is selected from H, CH₃, isobutyl, isopropyl, benzyl, R² of the group B2) is selected from —CH₂—OH, —CH(CH₃)—OH— or  —CH₂—[(C₆H₄)(4-OH)], or R² of the group B3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″,  —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, or —C(O)CH₃, R² of the group B4) is —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′,  —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl, T is —O—, —S—, —NR′—, —O—CH(R′)O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, Y is as below defined; or R_(X) is selected from (d1) —HN—CH(R²)—CH₂O-(T″′-Y—ONO₂) or (d2) —O—CH₂—CH(R¹²)—NH-(T′-Y—ONO₂) wherein R¹² of the group D1) is selected from H, CH₃, isobutyl, isopropyl, benzyl, or R¹² of the group D2) is selected from —CH₂—OH, —CH(CH₃)OH— or  —CH₂—[(C₆H₄)-(4-OH)], or R¹² of the group D3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″,  —(CH₂)₃—NHR″, —(CH₂)₄—NHR″ wherein R″ is H, or R¹² of the group D4) is CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′,  —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl, T′ and T″′ are each independently selected from —C(O)— or  —C(O)—X″ wherein X″ is —S— or —O—, Y is as below defined; or R_(X) is selected from: (d3) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂OH (d4) —O—CH₂—CH(R^(12a)-T″-Y—ONO₂)—NHR^(4a) (d7) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) or (d8) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂₎ wherein R^(12a) of the group D5) is selected from —CH₂—O—, —CH(CH₃)—O— or  —CH₂—[(C₆H₄)-(4-O)—], or R^(12a) of the group D6) is selected from —CH₂—NH—, —(CH₂)₂—NH—,  —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(12a) of the group D7) is —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, R^(4a) is H or —C(O)CH₃, T″ is selected from C(O)— or —C(O)—X″ wherein X″ is —S— or —O— when R^(12a) is selected from D5) or D6), T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl when R^(12a) is selected from D7), T″′ is selected from —C(O) or —C(O)—X″ wherein X″ is —S— or —O—, Y and Y′ are as below defined; or R_(X) is selected from: (d5) —R^(12b)—CH(NHR^(4a))—CH₂—O-(T″-Y—ON)₂) (d6) —R^(12b)—CH(CH₂O)—NH-(T′-Y—ONO₂) (d9) —R^(12b)—CH(NH-T′-Y′—ONO₂)—CH₂—O-(T″-Y—ONO₂) or (d10) —R^(12b)—CH(CH₂—O-T″′-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(12b) of the group D8) is selected from —O—CH(CH₃)—, —O—CH₂—,  [-4-O—(C₆H₄)]—CH₂—, or R^(12b) of the group D9) is selected from —HN—CH₂—, —HN—(CH₂)₂—,  —HN—(CH₂)₃—, —HN—(CH₂)₄—, R⁴, is H or —C(O)—CH₃, T′ and T″′ are each independently selected from —C(O)—,  —C(O)—X″, wherein X″ is —S— or —O—, Y and Y′ are each independently selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; d)

wherein: n is an integer from 0 to 2, R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—, n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; e)

n² is 1, R¹³ is CH₃, Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n^(2′) is 0, T₁ is —C(O)O— and U is a linear C₁-C₁₀ alkylene; e′)

wherein: n² is 1, R¹³ is CH₃, Y′ is —(CH₂)_(n) ^(2′)—CH═CH— and n^(2′) is 0, (T₁)′=—C(O)—, n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; f)

wherein T₂ is —O— or —S—, —NH— and n³ is 1 or 2, when Y and Y′ are selected from d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T′-Y—ONO₂), -(T″-Y′—ONO₂), -(T′-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group.
 3. The nitric oxide releasing compounds according to claim 2 wherein R_(X) is (a5) —R^(1b)—CH(NHR^(4a))—C(O)(T-Y—ONO₂) or (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) R^(1b) of the group A10) is —O—CH₂— or [-(4-O)—(C₆H₄)]—CH₂—, R^(4a) is H or —C(O)CH₃, T is selected from —O—, —S—, NR′— wherein R′ is as above defined, T′ is —C(O)— and Y and Y′ are each independently selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group.
 4. The nitric oxide releasing compounds according to claim 1 wherein a is 0 and R_(X) is (a2) —C(O)—CH(R¹)—NH-(T′-Y—ONO₂) wherein R¹ of the group A1) is selected from H, isobutyl, benzyl,  C₆H₅—CH₂—CH₂—, 2-monosubstituted benzyl, or 3-monosubstituted benzyl or 4-monosubstituted benzyl wherein the substituent of the benzyl is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN, C₆H₅CO—, R¹ of the group A2) is selected from —CH₂—OH, —CH(CH₃)OH— or  —CH₂—[(C₆H₄)-(4-OH)], or R¹ of the group A3) is selected from CH₂—NHR″, —(CH₂)₂—NHR″,  —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, or —C(O)CH₃, R¹ of the group A4) is selected from —CH₂—C(O)R″′,  —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl, T′ is —C(O)—, —C(O)—X₁ wherein X″ is —S— or —O—, Y is as below defined; or R_(X) is (a4) —C(O)—CH(R^(1a)-T″-Y′—ONO₂)—NHR^(4a) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)O— or —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is selected from CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—; R^(4a) is H or —C(O)CH₃, T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O— when R^(1a) is selected from the group A5) or A6), T″ is —O—, —S—, —NR′— or —O—CH(R′)—O—C(O)— wherein R′ is H or —CH₃ when R^(1a) is selected from the group A7), Y′ is as below defined; or R_(X) is selected from: (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) (a6) —R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂) (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) or (a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1b) of the group A10) is selected from —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, R^(3a) is H or a (C₁-C₅) alkyl, R^(4a) is H or —C(O)CH₃, T is —O—, —S—, —NR′— or —O—CH(R′)OC(O)— wherein R′ is H or  —CH₃, T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, Y and Y′ are as below defined; or R_(X) is (a8) —C(O)—CH(R^(1a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1a) of the group A5) is selected from −CH₂—O—, —CH(CH₃)—O— or  —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—,  —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is selected from —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, when R^(1a) is selected from the group A5) or A6), T″ is —O—, —S—, —NR′— or —O—CH(R′)O—C(O) wherein R′ is H or  —CH₃, when R^(1a) is selected from the group A7), T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, Y and Y′ are as below defined; or R_(X) is (b2) —C(O)—CH₂—CH(R²)—N-(T′-Y—ONO₂) wherein R² of the group B1) is selected from H, CH₃, isobutyl, isopropyl, benzyl, T′ is —C(O)—, —C(O)—X″ wherein X″ is —S— or —O—, Y and Y′ are each independently selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; d)

wherein: n² is an integer from 0 to 2, R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—, n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; e)

n² is 1, R¹³ is CH₃, Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n^(2′) is 0, T₁ is —C(O)O— and U is a linear C₁-C₁₀ alkylene; e′)

wherein: n² is 1, R¹³ is CH₃, Y¹ is —(CH₂)_(n) ^(2′)—CH═CH and n^(2′) is 0, (T₁)′=—O—C(O)—, n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; f)

wherein T₂ is —O— or —S—, —NH— and n³ is 1 or 2, when Y and Y′ are selected from d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T′-Y—ONO₂), -(T″-Y′—ONO₂), -(T′-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group.
 5. The nitric oxide releasing compounds according to claim 4 wherein R_(X) is (a2) —C(O)—CH(R¹)—NH-(T′-Y—ONO₂) wherein R¹ of the group A1) is H, T′ is —C(O)—, Y is selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group;
 6. The nitric oxide releasing compounds of claim 4 wherein R_(X) is selected from (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) (a6) —R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂) or (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) wherein R^(1b) of the group A10) is —C(O)—CH₂—, R^(3a) is H or a (C₁-C₅) alkyl, R^(4a) is H or —C(O)CH₃, T is selected from —O—, —S—, —NR′— wherein R′ is as above defined, T′ is —C(O)— and Y and Y′ are each independently selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group.
 7. The nitric oxide releasing compounds according to claim 4 wherein R_(X) is (b2) —C(O)—CH₂—CH(R²)—NH-(T′-Y—ONO₂) R² of the group B1) is H, T′ is —C(O)—, Y is selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group;
 8. Nitric oxide releasing compounds according to claim 3


9. Nitric oxide releasing compounds according to claim 5


10. Nitric oxide releasing compounds according to claim 6


11. Nitric oxide releasing compounds according to claim 7


12. Nitric oxide releasing compounds according to claim 1 wherein the respiratory diseases comprise asthma, chronic obstructive pulmonary diseases, Acute Respiratory distress syndrome, allergic rhinitis and respiratory tract diseases associated with inflammation.
 13. Nitric oxide releasing compounds of general formula (I) R-(Z)_(a)-R_(x)  (I) and pharmaceutically acceptable salts or stereoisomers thereof wherein R is a corticosteroid residue selected from:

a is 0 or 1, Z is a group capable of binding R_(X) and is selected from —C(O)—, or —CH(R′)—O— wherein R′ is selected from H or a straight or branched C₁-C₄ alkyl, preferably R′ is H or —CH₃; R_(X) is a radical selected from the Following meanings: A) (a1) —HN—CH(R¹)—C(O)-(T-Y—ONO₂) (a2) —C(O)—CH(R¹)—NH-(T′-Y—ONO₂) (a3) —HN—CH(R^(1a)-T″-Y′—ONO₂)—COOR^(3a) (a4) —C(O)—CH(R^(1a)-T″-Y′—ONO₂)—NHR^(4a) (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) (a6) —R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂) (a7) —HN—CH(R^(1a)-T″-Y′—ONO₂)—C(O)-(T-Y—ONO₂) (a8) —C(O)—CH(R^(1a)—-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) (a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T-Y—ONO₂) wherein: R¹ is selected from: A1) H, —CH₃, isopropyl, isobutyl, sec-butyl, tert-butyl, methylthio-(CH₂)₂—, phenyl, benzyl, C₆H₅—CH₂—CH₂—, 2-monosubstituted benzyl, or 3-monosubstituted benzyl or 4-monosubstituted benzyl wherein the substituent of the benzyl is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN, C6H₅CO—, 2,4-dichlorobenzyl, 3,4-dichlorobenzyl, 3,4-difluorobenzyl, 2-pyrrolidyl, 3-triptophanyl-CH₂—, 3-benzothienyl-C₁H₂—, 4-imidazolyl-CH₂—, 9-anthranyl-CH₂—, cyclohexyl, cyclohexyl-CH₂—, cyclohexyl-(CH₂)₂—, cyclopentyl-CH₂—, (C₆H₅)₂CH—, 4-B(OH)₂-benzyl, 4-quinolyl-CH₂—, 3-quinolyl-CH₂—, 2-quinolyl-CH₂—, 2-quinoxalyl-CH₂—, 2-furyl-CH₂—, 1-naphtyl-CH₂—, 2-naphtyl-CH₂—, 2-pyridyl-CH₂—, 3-pyridyl-CH₂—, 4-pyridyl-CH₂—, 2-thienyl-CH₂—, 3-thienyl-CH₂—, C₆H₄—CH═CH—CH₂—, CH₂═CH—CH₂—, CH≡CH—CH₂—, NH₂—CO—CH₂—, NH₂—CO—(CH₂)₂—, NH₂(═NH)NH—(CH₂)₃—, P(═O)(OCH₃)₂, A2) —CH₂—SH, —CH₂—OH, —CH(CH₃)—OH, —CH₂[(C₆H₄)-(4-OH)], —CH₂—[(C₆H₂)-(3,5-diiodo)-(4-OH)], —CH₂— [(C₆H₃)-(3-nitro)-(4-OH)], A3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, —C(O)CH₃ or

wherein R^(5a) is H or a linear or branched C₁-C₁₀ alkyl chain, A4) —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is —OR^(5a) or

wherein R^(5a) is as above defined, R^(1a) is selected from, A5) —CH₂—S—, —CH₂—O—, —CH(CH₃)—O—, —CH₂[(C₆H₄)-(4-O)—], —CH₂-[(3,5-diiodo)-(C₆H₂)-(4-O)—], —CH₂-[(3-nitro)-(C₆H₃)-(4-O)—], preferably R^(1a) is —CH₂—O—, A6) —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, A7) —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—; R^(3a) is selected from H, —R^(5a) or

wherein R^(5a) is as above defined, R^(4a) is selected from H or C(O)CH₃ or

wherein R^(5a) is as above defined, R^(1b) is selected from A8) —S—CH₂—, —O—CH(CH₃)—, —O—CH₂—, [-(4-O)—(C₆H₄)]—CH₂—, [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂—,  [-(4-O)-(3-nitro)-(C₆H₃)]—H₂—, A9) —HN—CH₂—, —HN—(CH₂)₂—, —HN—(CH₂)₃—, —HN—(CH₂)₄—, A10) —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—; T is selected from —C—, —S—, —NR′—, —O—CH(R′)—O—C(O)— or  —O—CH(R′)—O—C(O)O— wherein R′ is as above defined; T′ is —C(O)—, —C(O)—X″— wherein X″ is —O— or —S—, or T′ is  —C(O)—NR′— wherein R′ is as above defined, T″ is independently selected from —C(O)—, —C(O)—X″—,  —C(O)—NR′—, —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—,  —O—CH(R′)—O—C(O)O—, wherein X″ and R′ are as above defined, with the proviso that T″ is —C(O)—, —C(O)—X″— or —C(O)—NR′— when T″′ is linked to —NH—, —O—, or —S—, or T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)—, —O—CH(R′)—O—C(O)O— when T″ is linked to —C(O)—, Y and Y′ are as below defined, B) (b1) —HN—CH(R²)—CH₂C(O)-(T-Y—ONO₂) (b2) —C(O)—CH₂—CH(R²)—NH-(T′-Y—ONO₂) (b3) —HN—CH(R_(a)-T″-Y—ONO₂)—C—H₂COOR^(3a) (b4) —C(O)—CH₂—CH(R_(2a)-T″-Y′—ONO₂)—NHR^(4a) (b5) —R^(2b)—CH(NHR^(4a))—CH₂C(O)-(T-Y—ONO₂) (b6) —R^(2b)—CH(CH₂COOR^(3a))NH-(T′-Y—ONO₂) (b7) —HN—CH(R^(2a)-T″-Y′—ONO₂)—CH₂—C(O)-(T-Y—ONO₂) (b8) —C(O)—CH₂—CH(R^(2a)-T″-Y′—ONO₂)—NH-(T″-Y—ONO₂) (b9) —R^(2b)—CH(NH-T′-Y′—ONO₂)—CH₂C(O)-(T-Y—ONO₂) (b10) —R^(2b)—CH(CH₂C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R² is selected from B1) H, —CH₃, CF₃, isopropyl, isobutyl, sec-butyl, methylthio-(CH₂)₂—, phenyl, benzyl, 3-triptophanyl-CH₂—, NH₂—C(O)—CH₂—,  NH₂—C(O)—(CH₂)₂—, NH₂(═NH)NH—(CH₂)₃—, tBuO—CH(CH₃)—, benzyl-O—CH₂—, 4-terbutoxy-benzyl, 4-phenylbenzyl, B2) —CH₂—SH, —CH₂—OH, —CH(CH₃)—OH, —CH₂—[(C₆H₄)-(4-OH)],  CH₂—[(C₆H₂)-(3,5-diiodo)-(4-OH)],  —CH₂—[(C₆H₃)-(3-nitro)-(4-OH)], B3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is as above defined, B4) —CH₂—C(O)—R″′, —(CH₂)₂—C(O)—R″′, —(CH₂)₄—C(O)—R″′ wherein R″′ is as above defined, preferably R² is —CH₂—C(O)—R″′, R^(2a) is selected from: B5) —CH₂—S—, —CH₂—O—, —CH(CH₃)—O— or —CH₂—[(C₆H₄)-(4-O)—],  —CH₂-[(3,5-diiodo)-(C₆H₂)-(4-O)—],  —CH₂-[(3-nitro)-(C₆H₃)-(4-O)—]; B6) —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH, —(CH₂)₄—NH—, B7) —CH₂—C(O)—, —(CH₂)₂—C(O), —(CH₂)₄—C(O)—, R^(2b) is selected from: B8) —S—CH₂—, —O—CH(CH₃)—, —O—CH₂—, [-(4-O)—(C₆H₄)]—CH₂—, [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂—, [-(4-O)-(3-nitro)-(C₆H₃)]—CH₂, B9) —HN—CH₂—, —HN—(CH₂)₂—, —HN—(CH₂)₃—, —HN—(CH₂)₄—, B10) —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, R^(3a) and R^(4a) are as above defined, T, T′ and T″ are as above defined and Y and Y′ are as below defined, C) (c1) —HN—(CH₂)_(b)—C(O)-(T-Y—ONO₂); (c2) —C(O)—(CH₂)_(b)—NH-(T′-Y—ONO₂); wherein b is an integer from 3 to 6, T and T′ are as above defined and Y and Y′ are as below defined, D) (d1) —HN—CH(R¹²)—CH₂—O-(T″′-Y—ONO₂) (d2) —O—CH₂—CH(R¹²)—NH-(T′-Y—ONO₂) (d3) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂OH (d4) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NHR^(4a) (d5) —R^(12′—CH(NHR) ^(4a))—CH₂—O-(T″′-Y—ONO₂) (d6) —R^(12b)—CH(CH₂OH)—NH-(T′-Y—ONO₂) (d7) —HN—CH(R^(12a)-T″-Y′—ONO₂), —CH₂—O-(T″′-Y—ONO₂) (d8) —O—CH₂—CH(R^(12a)-T″-Y—ONO₂)—NH-(T″-Y—ONO₂) (d9) —R^(12b)—CH(NH-T′-Y′—ONO₂)—CH₂O-(T″′-Y—ONO₂) (d10) —R^(12b)—CH(CH₂—O-T″′-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein T″′ is independently selected from —C(O)—, —C(O)X″— wherein X″ is —O— or —S—, or —C(O)—NR′— wherein R′ is as above defined, T′ and T″ are as above defined, Y and Y′ are as below defined, R¹² is selected from: D1) H, —CH₃, isopropyl, isobutyl, sec-butyl, methylthio-(CH₂)₂—, benzyl, 3-triptophanyl-CH₂—, 4-imidazolyl-CH₂—,  NH₂—CO—CH₂—, NH₂—CO—(CH₂)₂—, NH₂(═NH)NH—(CH₂)₃—, D2) —CH₂—OH, —CH(CH₃)—OH, —CH₂—[(C₆H₄)-(4-OH)],  —CH₂—[(C₆H₃)-(3,5-diiodo)-(4-OH)],  —CH₂—[(C₆H₃)-(3-nitro)-(4-OH)], D3) —CH₂—NHR″, —(CH₂)₂—NHR″, —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is as above defined, preferably R¹² is —(CH₂)₄—NHR″, D4) —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, (CH₂)₄—C(O)R″′ wherein R″′ is as above defined, R^(12a) is selected from: D5) —CH₂—O—, —CH(CH₃)—O— or —CH₂—[(C₆H₄)-(4-O)—],  —CH₂-[3,5-diiodo-(C₆₁H₂)-(4-O)—], —CH₂-[3-nitro-(C₆H₃)-4-O—], D6) —CH₂—NH—, —(CH₂)₂—NH—, —(CH₂)₃—NH—, —(CH₂)₄—NH—, D7) —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, R^(12b) is selected from: D8) —O—CH₂—, —O—CH(CH₃)_(X)—, [(4-O)—(C₆H₄)]—CH₂—,  [-(4-O)-(3,5-diiodo)-(C₆H₂)]—CH₂, [-(4-O)-(3-nitro)-(C₆H₃)]—CH₂—, D9) —HN—CH₂—, —HN—(CH₂)₂— —HN—(CH₂)₃—, —HN—(CH₂)₄—, D10) —C(O)—CH₂—, —C(O)—(CH₂)₂, —C(O)—(CH₂)₄—, R^(4a) is as above defined, E)

wherein c is equal to 0 or 1, d is an integer from 0 to 3 with the proviso that c is 0 or 1 when d is 0 and c is 0 when d is 1, 2 or 3, T and T′ are as above defined and Y is as below defined; F)

(XI) wherein e and f are equal to 0 or 1, with the proviso that f is 0 when e is 0 and f is 0 or 1 when e is 1, T and T′ are as above defined and Y is as below reported; G)

wherein R³ is H, CH₃, propyl, (C₆H₅)₂CH—, 1-naphtyl-CH₂—, benzyl, allyl, 2-bromobenzyl, 2-chlorobenzyl, 3-chlorobenzyl, 4-fluorobenzyl, 4-bromobenzyl, 4-methylbenzyl, T and T′ are as above defined and Y is as below defined, H)

wherein R⁴ is H, benzyl, 4-bromobenzyl, 2-bromobenzyl, T and T′ are as above defined and Y is as below defined; I)

wherein R⁵ is H, R⁶ is H, or R⁵ and R⁶ when taken together are a double bond, T and T′ are as above defined and Y is as below reported; L)

wherein T and T′ are as above defined and Y is as below reported; M)

wherein T and T′ are as above defined and Y is as below reported; N)

wherein c is as above defined, d is equal to 0 or 1, T and T′ are as above defined and Y is as below reported; O)

wherein R⁷ is H, R⁸ is H, or R⁷ and R⁸ when taken together are a double bond, c is as above defined, T and T′ are as above defined and Y is as below reported; P)

wherein T and T′ are as above defined and Y is as below reported; Q)

wherein T and T′ are as above defined and Y is as below reported; R)

wherein T and T′ are as above defined and Y is as below reported; S)

wherein T and T′ are as above defined and Y is as below reported; T)

wherein T and T′ are as above defined and Y is as below reported; U)

wherein R⁹ and R¹⁰ are H, CH₃, R¹¹ is CH₃ or 4-piperidinyl with the proviso that R⁹ and R¹⁰ are H when R¹¹ is 4-piperidinyl and R⁹ and R¹⁰ are CH₃ when R¹¹ is CH₃, T and T′ are as above defined and Y is as below reported; V)

wherein T and T′ are as above defined and Y is as below reported; with the proviso that in the formula (I): a is 0 or a is 1 and Z is —CH(R′)—O— wherein R′ is as above defined, when R_(x) is: (a2), (a4) or (a8); (a5), (a6), (a9) or (a10) and R^(1b) is selected from the group A10); (b2), (b4) or (b8); (b5), (b6), (b9) or (b10) and R^(2b) is selected from the group B10); (c2); (d5), (d6), (d9) or (d10) and R^(12b) is selected from the group D10); (e2), (f1), (g2), (h1), (i1), (l2), (m2), (n2), (o2), (p2), (q2), (r2), (s2), (t1) or (u2); a is 1 and Z is —C(O)—, when R_(X) is: (a1), (a3) or (a7); (a5), (a6), (a9) or (a10) and R^(1b) is selected from the groups A8) and A9); (b1), (b3) or (b7); (b5), (b6), (b9) or (b10) and R^(2b) is selected from the groups B8) or B9); (c1); (d1), (d2), (d3), (d4), (d7) or (d8); (d5), (d6), (d9) or (d10) and R^(12b) is selected from the groups D8) or D9); (e1), (f2), (g1), (h2), (i2), (l1), (m1), (n1), (o1), (p1), (q1), (r1), (s1), (t2) or (u1). Y and Y′ are bivalent radicals each independently selected from the following meanings: a) straight or branched C₁-C₂₀ alkylene, straight or branched C₁-C₂₀ alkylene substituted with one or more of the substituents selected from the group consisting of: halogen atoms, hydroxy, —ONO₂ or T₂, wherein T₂ is —OC(O)(C₁-C₁₀ alkyl)-ONO₂ or —O(C₁-C₁₀ alkyl)-ONO₂; cycloalkylene with 5 to 7 carbon atoms into cycloalkylene ring, the ring being optionally substituted with one or more straight or branched C₁-C₁₀ alkyl chains; b)

wherein n⁰ is an integer from 0 to 20; n¹ is 0 or 1; U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group; c)

wherein n⁰ is an integer from 0 to 20; n¹ is 0 or 1; U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group; d)

wherein: n is an integer from 0 to 2, R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—; n¹ and U are as above defined; e)

n² is an integer from 0 to 2, R¹³ is H or CH₃, Y¹ is —CH₂—CH₂— or —CH═CH—(CH₂)_(n) ^(2′)—, wherein n^(2′) is 0 or 1, preferably Y¹ is —CH═CH—(CH₂)_(n) ^(2′) and n^(2′) is 0, T₁=—O—C(O)— or —C(O)O—, n¹ is 0 or 1, preferably n¹ is 1; U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group; e′)

wherein: n² is an integer from 0 to 2, R¹³ is H or CH₃, Y¹ is —CH₂—CH₂— or —(CH₂)_(n) ^(2′)—CH═CH—, wherein n^(2′) is 0 or 1, (T₁)′=—O—C(O)—; n¹ is 0 or 1, U is a linear or branched C₁-C₂₀ alkylene optionally substituted with a —ONO₂ group; f)

wherein T₂ is —O— or —S—, —NH—, when Y and Y′ are selected from b), c), d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T′-Y—ONO₂), -(T″-Y′—ONO₂), -(T′-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group; g)

wherein: n⁴ is an integer from 0 to 10, n⁵ is an integer from 1 to 10, R¹⁴, R¹⁵, R¹⁶, R¹⁷ are the same or different, and are H or straight or branched C₁-C₄ alkyl, wherein the —ONO₂ group is linked to

wherein n⁵ is as defined above; Y² is an heterocyclic saturated, unsaturated or aromatic 5 or 6 members ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulphur, and is selected from the group consisting of:


14. The nitric oxide releasing compounds according to claim 13 wherein a is 1 and Z is —C(O)—; R_(X) is (a1) —HN—CH(R¹)—C(O)-(T-Y—ONO₂) wherein R¹ of the group A1) is selected from H, isobutyl, benzyl, C₆H₅—CH₂—CH₂—, 2-monosubstituted benzyl, or 3-monosubstituted benzyl or 4-monosubstituted benzyl wherein the substituent of the benzyl is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN, C₆H₅CO— or R¹ of the group A2) is selected from —CH₂—OH, —CH(CH₃)—OH— or  —CH₂—[(C₆H₄)-(4-OH)], or R¹ of the group A3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″,  —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, or —C(O)CH₃, R¹ of the group A4) is —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl, T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, Y is as below defined; or R_(X) is (a3) —HN—CH(R^(1a)-T″-Y′—ONO₂)—COOR^(3a) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)O— or  —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —(H₂—NH, —(CH₂)₂—NH—,  —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, R^(3a) is H or a (C₁-C₅) alkyl, T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, when R^(1a) is selected from the group A5) or A6), T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, when R^(1a) is selected from the group A7), Y′ is as below defined; or R_(X) is selected from: (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) (a6) —R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂) (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) or (a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1b) of the group A8) is selected from —O—CH(CH₃)—, —O—CH₂—,  [-4-O)—(C₆H₄)]—CH₂—, or R^(1b) of the group A9) is selected from —HN—CH₂—, —HN—(CH₂)₂—,  —HN—(CH₂)₃—, —HN—(CH₂)₄—, R^(1b) of the group A10) is —O—CH₂— or [-4-O(C₆H₄)]—CH₂—, R^(3a) is H or a (C₁-C₅) alkyl; R^(4a) is H or —C(O)CH₃, T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, Y and Y′ are as below defined; or R_(X) is selected from: (a7) —HN—CH(R^(1a)-T″-Y′—ONO₂)—C(O)(—Y—ONO₂) wherein R^(1a) of the group A5) is selected from —CH₂O—, —CH(CH₃)—O— or  —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—,  —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—; T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, when R^(1a) is selected from A5) or A6), T″ is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, when R^(1a) is selected from A7), T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, Y and Y′ are as below defined; or R_(X) is selected from: (b1) —HN—CH(R²)—CH₂C(O)-(T-Y—ONO₂) wherein R² of the group B1) is selected from H, CH₃, isobutyl, isopropyl, benzyl; R² of the group B2) is selected from —CH₂—OH, —CH(CH₃)—OH— or  —CH₂—[(C₆H₄)(4-OH)], or R² of the group B3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″,  —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H, or —C(O)CH₃, R² of the group B4) is —(H₂—C(O)R″′, —(CH₂)₂—C(O)R″′,  —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl, T is —O—, —S—, —NR′—, —O—CH(R′)—O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl, Y is as below defined; or R_(X) is selected from: (d1) —HN—CH(R¹²)—CH₂—O-(T″-Y—ONO₂) (d2) —O—CH₂—CH(R¹²)—NH-(T′-Y—ONO₂) wherein R¹² of the group D1) is selected from H, CH₃, isobutyl, isopropyl, benzyl, or R¹² of the group D2) is selected from —CH₂—OH, —CH(CH₃)OH— or  —CH₂—[(C₆H₄)-(4-OH)], or R¹² of the group D3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″,  —(CH₂)₃—NHR″, —(CH₂)₄—NHR″ wherein R″ is H, or R¹² of the group D4) is —CH₂—C(O)R″′, —(CH₂)₂—C(O)R″′,  —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl, T′ and T″′ are each independently selected from —C(O)— or  —C(O)—X″ wherein X″ is —S— or —O—, Y is as below defined; or R_(X) is selected from: (d3) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂OH (d4) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NHR^(4a) (d7) —HN—CH(R^(12a)-T″-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) or (d8) —O—CH₂—CH(R^(12a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(12a) of the group D5) is selected from —CH₂—O—, —CH(CH₃)—O— or  —CH₂—[(C₆H₄)-(4-O)—], or R^(12a) of the group D6) is selected from —CH₂—NH—, —(CH₂)₂—NH—,  —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(12a) of the group D7) is —CH₂—C(O)—, —(C112)₂—C(O)—, —(C H₂)₄—C(O)—, R^(4a) is H or —C(O)CH₃, T″ is selected from —C(O)— or —C(O)—X″ wherein X″ is —S— or —O— when R^(12a) is selected from D5) or D6), T″ is —O—, —S—, —NR′—, —O—CH(R′)O—C(O)— wherein R′ is H or a straight or branched C₁-C₄ alkyl when R^(12a) is selected from D7), T″′ is selected from —C(O)— or —C(O)X″ wherein X″ is —S— or —O—, Y and Y′ are as below defined; or R_(X) is selected from: (d5) —R^(12b)—CH(NHR^(4a))—CH₂—O-(T″′-Y—ONO₂) (d6) —R^(12b)—CH(CH₂OH)—NH-(T′-Y—ONO₂) (d9) —R^(12b)—CH(NH-T′-Y′—ONO₂)—CH₂—O-(T″′-Y—ONO₂) or (d10) —R^(12b)—CH(CH₂—O-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(12b) of the group D8) is selected from —O—CH(CH₃)—, —O—CH₂—,  [-4-O—(C₆H₄)]—CH₂—, or R^(12b) of the group D9) is selected from —HN—CH₂—, —HN—(CH₂)₂—,  —HN—(CH₂)₃—, —HN—(CH₂)₄—, R^(4a) is H or —C(O)—CH₃, T′ and T″′ are each independently selected from —C(O)—,  —C(O)—X″, wherein X″ is —S— or —O—, Y and Y′ are each independently selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; d)

wherein: n² is an integer from 0 to 2 R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—, n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; e)

n² is 1, R¹³ is CH₃, Y¹ is —CH═CH—(CH₂)_(n) ^(2′)— and n^(2′) is 0, T₁ is —C(O)O— and U is a linear C₁-C₁₀ alkylene;

wherein: n² is 1, R¹³ is CH₃, Y¹ is —(CH₂)_(n) ^(2′)—CH═CH— and n^(2′) is 0, (T₁)′=—O—C(O)—, n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; f)

wherein T₂ is —O— or —S—, —NH—, n³ is 1 or 2, when Y and Y′ are selected from d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T′-Y—ONO₂), -(T″-Y′—ONO₂), (T′-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group.
 15. The nitric oxide releasing compounds according to claim 14 wherein R_(X) is (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) or (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) R^(1b) of the group A10) is —O—CH₂— or [-4-O—(C₆H₄)]—CH₂—, R^(4a) is H or —C(O)CH₃, T is selected from —O—, —S—, —NR′— wherein R′ is as above defined, T′ is —C(O)— and Y and Y′ are each independently selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group.
 16. The nitric oxide releasing compounds according to claim 13 wherein a is 0 and R_(X) is (a2) —C(O)—CH(R¹)—NH-(T′Y—ONO₂) wherein R¹ of the group A1) is selected from H, isobutyl, benzyl,  C₆H₅—CH₂—CH₂—, 2-monosubstituted benzyl, or 3-monosubstituted benzyl or 4-monosubstituted benzyl wherein the substituent of the benzyl is selected from —F, —Cl, I, —NO₂, —CF₃, —CH₃, CN, C₆H₅CO—, R¹ of the group A2) is selected from —CH₂—OH, —CH(CH₃)OH— or  —CH₂—[(C₆H₄)-(4-OH)], or R¹ of the group A3) is selected from —CH₂—NHR″, —(CH₂)₂—NHR″,  —(CH₂)₃—NHR″, —(CH₂)₄—NHR″, wherein R″ is H or —C(O)CH₃, R¹ of the group A4) is selected from —CH₂—C(O)R″′,  —(CH₂)₂—C(O)R″′, —(CH₂)₄—C(O)R″′ wherein R″′ is OR^(5a) wherein R^(5a) is H or a linear (C₁-C₅) alkyl, T′ is —C(O)—, —C(O)—X″ wherein X″ is —S— or —O—, Y is as below defined; or R_(X) is (a4) —C(O)—CH(R_(1a)-T″-Y′—ONO₂)—NHR^(4a) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)O— or —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—,  —(CH₂)₃—NH—, —(CH₂)₄—NH, or R^(1a) of the group A7) is selected from —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—; R^(4a) is H or —C(O)CH₃, T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O— when R^(1a) is selected from the group A5) or A6), T″ is —O—, —S—, —NR′— or —O—CH(R′)—O—C(O)— wherein R′ is H or  —CH₃ when R^(1a) is selected from the group A7)₅ Y′ is as below defined; or R_(X) is selected from: (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T-Y—ONO₂) (a6) R^(1b)—CH(COOR^(3a))NH-(T′-Y—ONO₂) (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T-Y—ONO₂) or (a10) —R^(1b)—CH(C(O)-T-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1b) of the group A10) is selected from —C(O)—CH₂—, —C(O)—(CH₂)₂—, —C(O)—(CH₂)₄—, R^(3a) is H or a (C₁-C₅) alkyl, R^(4a) is H or —C(O)CH₃, T is —O—, —S—, —NR′— or —O—CH(R′)—O—C(O)— wherein R′ is H or —CH₃, T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, Y and Y′ are as below defined; or R_(X) is (a8) —C(O)—CH(R_(a)-T″-Y′—ONO₂)—NH-(T′-Y—ONO₂) wherein R^(1a) of the group A5) is selected from —CH₂—O—, —CH(CH₃)—O— or  —CH₂—[(C₆H₄)-(4-O)—], or R^(1a) of the group A6) is selected from —CH₂—NH—, —(CH₂)₂—NH—,  —(CH₂)₃—NH—, —(CH₂)₄—NH—, or R^(1a) of the group A7) is selected from —CH₂—C(O)—, —(CH₂)₂—C(O)—, —(CH₂)₄—C(O)—, T″ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, when R^(1a) is selected from the group A5) or A6), T″ is —O—, —S—, —NR′— or —O—CH(R′)—OC(O)— wherein R′ is H or —CH₃, when R^(1a) is selected from the group A7); T′ is —C(O)— or —C(O)—X″ wherein X″ is —S— or —O—, Y and Y′ are as below defined; or R_(X) is (b2) —C(O)—CH₂—CH(R²)—NH-(T′-Y—ONO₂) wherein R² of the group B1) is selected from H, CH₃, isobutyl, isopropyl, benzyl; T′ is —C(O)—, —C(O)—X″ wherein X″ is —S— or —O—, Y and Y′ are each independently selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁₋₁₀ alkylene substituted with a —ONO₂ group; d)

wherein: n² is an integer from 0 to 2, R¹³ is H or CH₃, T₁ is —O—C(O)— or —C(O)O—, n¹ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; e)

n² is 1, R¹³ is CH₃, Y¹ is —CH═CH—(CH₂)_(n) ²— and n² is 0, T₁ is —C(O)O— and U is a linear C₁-C₁₀ alkylene; e′)

wherein: n² is 1, R¹³ is CH₃, Y¹ is —(CH₂)_(n) ^(2′)—CH═CH— and n^(2′) is 0, (T₁)′=—O—C(O)—, n′ is 1 and U is a linear C₁-C₁₀ alkylene or U is a linear or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group; f)

wherein T₂ is —O— or —S—, —NH—, n³ is 1 or 2, when Y and Y′ are selected from d), e), e′) or f), the —ONO₂ group of -(T-Y—ONO₂), -(T′-Y—ONO₂), -(T″-Y′—ONO₂), -(T′-Y′—ONO₂), -(T″′-Y—ONO₂) and -(T″′-Y′—ONO₂) is linked to the —(CH₂)*— group.
 17. The nitric oxide releasing compounds according to claim 16 wherein R_(X) is (a2) —C(O)—CH(R¹)—NH-(T′-Y—ONO₂) wherein R¹ of the group A1) is H, T′ is —C(O)—, Y is selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group.
 18. The nitric oxide releasing compounds of claim 16 wherein R_(X) is selected from (a5) —R^(1b)—CH(NHR^(4a))—C(O)-(T′-Y—ONO₂) (a6) —R^(1b)—CH(COOR³NH-(T′-Y—ONO₂) or (a9) —R^(1b)—CH(NH-T′-Y′—ONO₂)—C(O)-(T′-Y—ONO₂) wherein R^(1b) of the group A10) is —C(O)—CH₂—, R^(3a) is H or a (C₁-C₅) alkyl, R^(4a) is H or —C(O)CH₃, T is selected from —O—, —S—, —NR′— wherein R′ is as above defined, T′ is —C(O)— and Y and Y′ are each independently selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group.
 19. The nitric oxide releasing compounds according to claim 16 wherein R_(X) is (b2) —C(O)—CH₂—CH(R²)—NH-(T′-Y—ONO₂) R² of the group B1) is H, T′ is —C(O)—, Y is selected from a) a straight or branched C₁-C₁₀ alkylene, a straight or branched C₁-C₁₀ alkylene substituted with a —ONO₂ group;
 20. Nitric oxide releasing compounds according to claim 13


21. Nitric oxide releasing compounds according to claim 17


22. Nitric oxide releasing compounds according to claim 18


23. Nitric oxide releasing compounds according to claim 19


24. Nitric oxide releasing compounds according to claim 13 for use as medicament.
 25. Pharmaceutical composition comprising a nitric oxide releasing compound of formula (I) according to claim 13 and a pharmaceutical acceptable excipient.
 26. A composition comprising a nitric oxide releasing compound of formula (I) according to claim 13 and at least one bronchodilator or a pharmaceutical acceptable salt or solvate thereof.
 27. The composition according to claim 26 wherein the bronchodilator is selected from anticholinergic bronchodilators, β₂-agonists, ephedrine or xanthines.
 28. The composition according to claim 25 wherein the nitric oxide releasing compound and the bronchodilator are administered simultaneously.
 29. The composition according to claim 25 wherein the nitric oxide releasing compound and the bronchodilator are administered sequentially.
 30. The composition according to claim 29 wherein the nitric oxide releasing compound is administered before or after the bronchodilator.
 31. The composition according to claim 25 for use in the treatment of respiratory diseases.
 32. The composition according to claim 31 wherein respiratory diseases comprise asthma, chronic obstructive pulmonary diseases, acute respiratory distress syndrome, allergic rhinitis and respiratory tract diseases associated with inflammation.
 33. The composition according to claim 25 pharmaceutical acceptable excipient. 